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The Incyte Genomics, Inc. patent solves the following problem:
Guanine nucleotide cost protein (GTP-binding proteins) present in all eukaryotic cells and the function of processes including metabolism, cellular growth, inequality, signal transduction, cytoskeletal organization, and intracellular vesicle transport and secretion. In higher organisms that are involved in signaling regulates such processes as immune responses (Aussel et al (1988) J Immunol 140: 215-220)., Apoptosis, contrast, and cell proliferation and oncogenesis ( Dhanasekaran et al (1998) Oncogene 17: 1383-1394).
Our analysis of this patent is as follows:
Incyte Genomics, Inc.’s patent US 6509155 B1 deals with Nucleic acids encoding GTPase activating proteins.
invention provides mammal nucleic acid molecules and fragments thereof. It also provides for the use of mammal nucleic acid molecules for the characterization, diagnosis, evaluation, treatment, or prevention of conditions, diseases and disorders associated with cell signaling, immune system, and cell proliferation, especially colon cancer. the invention further provides expression vector and host cells for production of proteins encoded in the mammalian nucleic acid molecule.
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