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The Incyte Corporation patent solves the following problem:
Proteases cleave proteins and peptides in the peptide bond which forms the backbone of the protein or peptide chain. Proteolysis is one of the most important and often enzymatic reactions that occur both inside and outside the cells. Proteolysis is responsible for the activation and maturation of growing polypeptides, the degradation of misfolded and damaged proteins, and the controlled turnover of the peptide within the cell. Proteases involved in digestion, endocrine function, and tissue remodeling during embryonic development, wound healing and normal growth. Proteases play a role in the regulatory process by affecting half the life of the regulatory protein. Proteases involved in the etiology or progression of diseases such as inflammation, angiogenesis, tumor scattering and metastasis, cardiovascular disease, neurological disease, and the bacteria, parasitic, and viral infections.
Our analysis of this patent is as follows:
Incyte Corporation’s patent US 6927056 B2 deals with Proteases.
invention provides in one cysteine proteases and polynucleotides that encode proteases. invention also provides expression vector, host cells, antibodies, agonists and antagonists, as well as methods for diagnosing, treating, or preventing diseases associated with aberrant expression of cysteine proteases.
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