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The Incyte Corporation patent solves the following problem:
Change protein phosphorylation is ubiquitous methods used to control many of intracellular events in eukaryotic cells. It is estimated that more than ten percent of the active protein in a typical mammal cell are phosphorylated. Kinases to facilitate the transfer of high-energy phosphate group from adenosine triphosphate (ATP) to the target protein hydroxyamino acid residues serine, threonine, or tyrosine. Phosphatases, in contrast, take the phosphate groups. Extracellular signal including the hormone, neurotransmitter, growth and inequality factors may activate kinases, which takes place as the cell surface of cells or as activator in the final effector proteins, as well as other places along the way signal transduction. Cascade of kinases occur, as well as sensitive kinases second messenger molecules. This system allows for equipment to amplify the weak signal (lower abundance of growth factor molecules, for example), as well as the synthesis of many weak signal into an all-or-nothing answer. Phosphatases, then, is necessary to determine the extent of phosphorylation in cells and, with kinases, controlling key cellular processes such as metabolic enzyme activity, proliferation, cell growth and inequality, cell adhesion, and cell cycle progression.
Our analysis of this patent is as follows:
Incyte Corporation’s patent US 7029897 B2 deals with Human protein phosphatase 2C.
invention provides human kinases and phosphatases (KAP) and polnucleotides to recognize and encode KAP. invention also provides expresson vector, host cells, antibodies, agonists and antagonists. invention also provides methods for diagnosing, treating, or preventing diseases associated with aberrant expression of KAP.
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