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The Incyte Corporation patent solves the following problem:
Kinases comprise the largest known enzyme forms and vary widely in their target molecules. Kinases to facilitate the transfer of high energy phosphate group from a phosphate donor to an acceptor phosphate. Nucleotides often serve as the phosphate donor in these reactions, with most of kinases using adenosine triphosphate (ATP). The phosphate acceptor can be any of a variety of molecules, including nucleosides, nucleotides, lipids, carbohydrates, and proteins. Phosphorylated proteins hydroxyamino acid. In addition to a phosphate group to the local office of the acceptor molecules, causing internal conformational changes and the potential influence intermolecular contacts. Change protein phosphorylation is the primary means of controlling protein activity in eukaryotic cells. In general, proteins activating phosphorylation in response to extracellular signals such as hormones, neurotransmitters, growth and division causes. The activated protein promotes intracellular response in the cell by means of intracellular signaling path and second messenger molecules such as cyclic nucleotides, calcium-calmodulin, inositol, and the various mitogens, which regulate protein phosphorylation.
Our analysis of this patent is as follows:
Incyte Corporation’s patent US 7112426 B2 deals with Human cAMP-dependent protein kinase beta-catalytic subunit.
human invention provides human kinases (PKIN) and polynucleotides which identify and encode PKIN. invention also provides expression vector, host cells, antibodies, agonists and antagonists. invention also provides methods for diagnosing, treating, or preventing diseases associated with aberrant expression of PKIN.
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