Phosphodiesterases

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The Baughn Mariah R, , Lu Dyung Aina M, , Henry Yue, , Tang Y Tom, , Nguyen Danniel B patent solves the following problem:

Phosphodiesterases to create a class of enzymes that accelerate the hydrolysis of the two chains Ester with a phosphate compound. Phosphodiesterases therefore very important in a variety of cellular processes. Phosphodiesterases include DNA and RNA endonucleases and exonucleases, necessary for cell growth and reproduction, and topoisomerases, which break and after nucleic acid strands in the topological arrangement of the DNA. A Tyr-DNA phosphodiesterase functions in DNA repair by hydrolyzing dead-end covalent intermediates formed between topoisomerase I and DNA (Pouliot, JJ et al (1999) Science 286: 552-555; Yang, S.- W . (1996) Proc. …. Natl Acad Sci USA 93: 11534-11539).

Our analysis of this patent is as follows:

Baughn Mariah R, , Lu Dyung Aina M, , Henry Yue, , Tang Y Tom, , Nguyen Danniel B’s patent US 7122362 B2 deals with Phosphodiesterases.
human invention provides phosphodiesterases (HPDE) and polynucleotides which identify and encode HPDE. invention also provides expression vector, host cells, antibodies, agonists and antagonists. invention also provides methods for diagnosing, treating, or preventing diseases associated with aberrant expression of HPDE.

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Isolation and use of solid tumor stem cells

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The Regents Of The University Of Michigan patent solves the following problem:

Cancer remains the number two cause of death in this country, resulting in more than 500,000 deaths each year. Despite progress in detection and treatment, cancer mortality remains high. Despite remarkable progress in understanding the molecular basis of cancer, this knowledge has not yet translated into effective therapeutic strategies.

Our analysis of this patent is as follows:

Regents Of The University Of Michigan’s patent US 7115360 B2 deals with Isolation and use of solid tumor stem cells.
A small percentage of cells in a firm with strong tumor properties of stem cells. These strong tumor stem cells give rise to two more tumor stem cells and the majority of tumor cells that have lost the capacity for growth and the ability to give rise to new tumors. Therefore, strong tumor heterogeneity appeared before the tumor cell line arising from a strong tumor stem cells.

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