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The Baughn Mariah R, , Lu Dyung Aina M, , Henry Yue, , Tang Y Tom, , Nguyen Danniel B patent solves the following problem:
Phosphodiesterases to create a class of enzymes that accelerate the hydrolysis of the two chains Ester with a phosphate compound. Phosphodiesterases therefore very important in a variety of cellular processes. Phosphodiesterases include DNA and RNA endonucleases and exonucleases, necessary for cell growth and reproduction, and topoisomerases, which break and after nucleic acid strands in the topological arrangement of the DNA. A Tyr-DNA phosphodiesterase functions in DNA repair by hydrolyzing dead-end covalent intermediates formed between topoisomerase I and DNA (Pouliot, JJ et al (1999) Science 286: 552-555; Yang, S.- W . (1996) Proc. …. Natl Acad Sci USA 93: 11534-11539).
Our analysis of this patent is as follows:
Baughn Mariah R, , Lu Dyung Aina M, , Henry Yue, , Tang Y Tom, , Nguyen Danniel B’s patent US 7122362 B2 deals with Phosphodiesterases.
human invention provides phosphodiesterases (HPDE) and polynucleotides which identify and encode HPDE. invention also provides expression vector, host cells, antibodies, agonists and antagonists. invention also provides methods for diagnosing, treating, or preventing diseases associated with aberrant expression of HPDE.
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