BTL-II proteins

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The Immunex Corporation patent solves the following problem:

Modulation of an immune or inflammatory response can be a valuable tool to control various types of diseases including autoimmune diseases, diseases characterized by abnormal inflammation and / or immune response, and infections . In treating diseases characterized by abnormal inflammation and / or immune responses, such as inflammatory bowel disease and autoimmune or inflammatory diseases, modulation of an immune response is desirable. In other situations, for example when the vaccine to a patient to give immunity to an infectious disease, stimulation of an immune response is desirable. In the case of vaccines, adjuvants on an immune response to a coadministered antigen can be valuable in providing long term protection against the disease. Particularly lacking in the art is the adjuvants capable of stimulating a mucosal immune response. A mucosal immune response, as opposed to a systemic immune response, is valuable because it attacks an infection with a very common point of entry, that is, to a mucosal surface. The present invention addresses these needs in the art by providing therapeutic agents for the diagnosis and treatment of diseases characterized by inadequate and / or abnormal inflammation and / or immune response and therapeutic agents that act as adjuvants to stimulate an immune response, particularly a mucosal immune response.

Our analysis of this patent is as follows:

Immunex Corporation’s patent US 7244822 B2 deals with BTL-II proteins.
invention provides isolated BTL-II protein, nucleic acid, antibody, enemies, and agonists and methods of making and using the same. Diagnostic, screening, and therapeutic methods of using the compositions of the invention given. For example, the composition of the invention can be used for diagnosis and treatment of inflammatory intestinal diseases and for the development of a mucosal immune response to an antigen.

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