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The Glaxo Group Limited patent solves the following problem:
US Pat. . Nos 3,979,399, 3,840,546, and 3,966,746 (ER Squibb & sons) disclose 4-amino pyrazolo [3,4-b] pyridine-5-carboxamide compounds of the following formula and salts thereof:
Our analysis of this patent is as follows:
Glaxo Group Limited’s patent US 7465743 B2 deals with Pyrazolo[3,4-b]pyridine compounds, and their use as PDE4 inhibitors.
The invention relates to a compound of formula (I) or a salt thereof: where: R1 is Et, n-Pr, i-Pr, C2fluoroalkyl, or CH2CH2OH; R2 is H, Me, Et, n-Pr, i-Pr, C1-2fluoroalkyl, cyclopropyl or (cyclopropyl) methyl; and NHR3 a sub-formula (nhr3): where R3A is methyl or ethyl; R3b is H, methyl or ethyl; R3C is H, methyl or ethyl, R3d is H, methyl or ethyl, and R3E is H or methyl, provided that: (a) R3B is methyl or ethyl; and / or (b) R3C and R3d independently methyl or ethyl; and provided that: (c) when R3C is ethyl and / or when R3d is ethyl and / or when R3E is methyl, then: R3A are methyl and / or R3B is hydrogen or methyl. These compounds are PDE4 inhibitor.
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