Aminopyrimidines as Syk inhibitors

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The Merck Sharp & Dohme Corp., , Merck Canada Inc. patent solves the following problem:

Spleen Tyrosine Kinase (SYK) is a protein tyrosine kinase described as a key mediator of immunoreceptor signaling a host of inflammatory cells including mast cells, B-cells, macrophages and neutrophils. These immunoreceptors, including Fc receptor and the B-cell receptor, is important for allergic diseases, and antibody-mediated autoimmune diseases and thus pharmacologically interfering SYK conceivably treat these diseases.

Our analysis of this patent is as follows:

Merck Sharp & Dohme Corp., , Merck Canada Inc.’s patent US 8735417 B2 deals with Aminopyrimidines as Syk inhibitors.
The present invention provides new pyrimidine amines of formula (I), which is a strong inhibitor of spleen tyrosine kinase, and is useful in the treatment and prevention of diseases mediated by said enzyme, such as asthma, COPD and rheumatoid arthritis.

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Cross-environment communication using application space API

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The Z124 patent solves the following problem:

This relates generally to the field of mobile environments Computing, and especially to support many user environment through the use of multiple operating systems on a single mobile computing device.

Our analysis of this patent is as follows:

Z124’s patent US 8726294 B2 deals with Cross-environment communication using application space API.
A mobile computing devices with a mobile operating systems and desktop operating systems running simultaneously and independently on a shared grain without virtualization. The mobile operating system provides a mobile user experience as the desktop operating system provides a complete desktop user experience when the mobile computing device is docked to a secondary terminal environment. Applications in desktop operating systems to communicate with applications and services in the mobile operating system with a framework cross-communication environment. The cross-premises communication structure may include application programming interfaces through which categories of applications communicate across a multiple computing environment operating system through category-specific calls remote communication. The mobile computing device may be a smartphone running the Android mobile operating system and a complete desktop Linux distribution on a modified Android kernel.

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Preventing diseases in infants delivered via caesarean section

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The N.V. Nutricia patent solves the following problem:

Human milk contains non-digestible oligosaccharides which specifically stimulate the growth of lactic acid bacteria, such as species belonging to the genus Bifidobacterium and Lactobacillus and prevent the growth and / or adhesion to the intestinal wall of other ( pathogenic) bacteria. Therefore, when a child receives human milk, intestinal flora in infants into a healthy plant rich in lactic acid bacteria. The presence of a healthy intestinal flora improves gut barrier maturation and / or gut barrier integrity, stimulates make mucus, inhibits pathogenic bacteria and stimulates the immune system.

Our analysis of this patent is as follows:

N.V. Nutricia’s patent US 8715769 B2 deals with Preventing diseases in infants delivered via caesarean section.
The present invention provides the use of a composition comprising non-digestible oligosaccharide for the manufacture of a composition for enteral administration of a baby delivered by caesarean section.

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Compositions comprising signal peptide-containing proteins

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The Incyte Corporation patent solves the following problem:

Protein transport is essential for cellular function. Transport in a protein may be mediated by a peptide signal located at the amino terminal protein itself. The signal peptide consists of ten to twenty hydrophobic amino acids that target the nascent protein from ribosome to a particular membrane bound compartment such as the endoplasmic reticulum (ER). Protein target the ER to continue by way secretory or stay in any of the secretory organelles such as the ER, Golgi apparatus, or lysosomes. Proteins that transit through the secretory way be secreted into the extracellular space or left in the plasma membrane. Secreted proteins are often synthesized as inactive precursors because of the post-translation processing events during transit through the secretory way. Such events include glycosylation, phosphorylation, proteolysis, and removal of the signal peptide with a signal peptidase. The other events that occur during the transport proteins include chaperone-dependent expression and folding of nascent proteins and protein interaction with a receptor or pore complex. Examples of secreted proteins with amino terminal signal peptide described below and include the receptor, extracellular matrix molecules, cytokines, hormones, growth and diversity factor, neuropeptides, vasomediators, phosphokinases, phosphatases, phospholipases, phosphodiesterases, G and Ras-related protein, Ion channels, pedagogue / pump, proteases, and transcription factors. (Reviewed in Alberts, B. et al. (1994) Molecular Biology of the Cell, garland Publishing, New York, NY, pp. 557-560, 582-592.)

Our analysis of this patent is as follows:

Incyte Corporation’s patent US 8716445 B2 deals with Compositions comprising signal peptide-containing proteins.
human invention provides signal peptide-containing proteins (HSPP) and polynucleotides which identify and encode HSPP. invention also provides expression vector, host cells, antibodies, agonists and antagonists. invention also provides methods for diagnosing, treating, or preventing diseases associated with expression of HSPP.

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Resonant leaky-mode photonic elements and methods for spectral and polarization control

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The University Of Connecticut patent solves the following problem:

The present disclosure relates to a strategic new areas of optical devices and, particularly, the Optical devices based on sound dripped through each modulated films.

Our analysis of this patent is as follows:

University Of Connecticut’s patent US 8718415 B2 deals with Resonant leaky-mode photonic elements and methods for spectral and polarization control.
Optical devices with versatile spectral values ​​given charged with one or more modulated and uniform layers to realize drip-mode resonance operation and a versatile spectral-band design. The first and / or higher number of evanescent diffraction orders applied to excite one or more dropped by. The one- or two-dimensional each building, carved by the proper distribution of the materials in each period, have a result that is or asymmetric profile allowing an expanded range sound devices drop-mode realized. Therefore, the quality of the optical permit devices, among other things, race alongside resonance frequency or wavelength, easily forming the reflection and transmission spectra for the optical device to be fulfilled, and the resonance wavelength areas that can be precisely controlled to affect the size of the drop can be with each other. Moreover, the corrupt profile allows for accurate spectral distance interactive dropped by to give greater flexibility to the Optical design device.

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