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The Merck Sharp & Dohme Corp., , Merck Canada Inc. patent solves the following problem:
Spleen Tyrosine Kinase (SYK) is a protein tyrosine kinase described as a key mediator of immunoreceptor signaling a host of inflammatory cells including mast cells, B-cells, macrophages and neutrophils. These immunoreceptors, including Fc receptor and the B-cell receptor, is important for allergic diseases, and antibody-mediated autoimmune diseases and thus pharmacologically interfering SYK conceivably treat these diseases.
Our analysis of this patent is as follows:
Merck Sharp & Dohme Corp., , Merck Canada Inc.’s patent US 8759366 B2 deals with Aminopyrimidines as SYK inhibitors.
The present invention provides new pyrimidine amines of formula (I), which is a strong inhibitor of spleen tyrosine kinase, and is useful in the treatment and prevention of diseases mediated by said enzyme, such as asthma, COPD and rheumatoid arthritis.
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