BTK inhibitors

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The Merck Sharp & Dohme Corp. patent solves the following problem:

B lymphocyte activation is key to the generation of adaptive immune responses. Derailed B lymphocyte activation is a sign of many autoimmune diseases and in the modulation of the immune response and therapeutic interest. Recently the success of B cell therapy in autoimmune disease is established. Treatment of rheumatoid arthritis (RA) patients with Rituximab (anti-CD20 therapy) is an accepted clinical therapy today. More recent clinical trial studies showed that treatment with Rituximab also ameliorates symptoms of the disease in relapsing remitting multiple sclerosis (RRMS) and systemic lupus erythematosus (murder) patients. This success supports the potential for future therapies for autoimmune diseases targeted B cell immunity.

Our analysis of this patent is as follows:

Merck Sharp & Dohme Corp.’s patent US 9446130 B2 deals with BTK inhibitors.
The present invention provides Bruton's tyrosine kinase (Btk) inhibitor compounds according to Formula I or pharmaceutically acceptable salt thereof. Formula I or a pharmaceutically acceptable salt thereof or pharmaceutical compositions comprising these compounds and their use in therapy. In particular, the present invention relates to the use of Btk inhibitor compounds for the treatment of Btk mediated disorder.

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Compounds

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The Glaxo Group Limited patent solves the following problem:

Syk is a non-receptor tyrosine kinase involved in coupling activated immunoreceptors signal consuming events that mediate diverse cellular responses, including proliferation, distinction, and phagocytosis. Syk is widely expressed in hematopoietic cells. Syk inhibitor with potential anti-inflammatory and immunomodulating activities. They inhibit SYK-mediated IgG Fc epsilon and gamma receptor and BCR receptor signaling, resulting in inhibition of activation of mast cells, macrophages, and B-cells and relevant inflammatory responses and tissue damage. Mast cells play a major role in type I hypersensitivity reactions associated with urticaria, bronchial asthma, anaphylaxis and other allergic conditions. Therefore, SYK inhibitor has attracted interest from a number of therapeutic areas, including the treatment of rheumatoid arthritis, B-cell lymphoma, asthma, rhinitis and cutaneous disorders such as acute and chronic urticaria, mastocytosis, cutaneous lupus , atopic dermatitis, autoimmune bullous conditions including Pemphigus and pemphigoid and other mast cell mediated skin disease.

Our analysis of this patent is as follows:

Glaxo Group Limited’s patent US 9447074 B2 deals with Compounds.
A compound of formula (I): or a salt thereof; which is an inhibitor of spleen tyrosine kinase (SYK) and therefore potential use in the treatment of diseases resulting from inappropriate activation of mast cells, macrophages, and B-cells and related inflammatory responses and tissue damage, for example inflammatory diseases and / or allergic conditions, in cancer therapy, especially heme malignancies, and autoimmune conditions.

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Aerodynamic structures secured to the underbody of cargo bodies

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The Stemco Lp patent solves the following problem:

Trucking is the primary means of long-distance and short-haul transportation of goods and materials in the United States, and in many other countries. Trucks often include a motorized cab where the driver sits and working on cars. cab attached to a box-like cargo section. Smaller trucks often include an integrated cargo section sitting in a unified framework which extends from the front wheels to the rear wheel assembly. The larger trucks often includes a detachable cab unit, with many driven axles, and a special trailer with a long box-like cargo units served on two or more phrases assemblies wheels. These trucks assemblages commonly called semi-trailers or tractor trailers. Most modern trucks' cabs, especially for tractor trailers, fitted with aerodynamic fairings on the roof, side and front. These fairings to help direct air over the exposed surface of the box-like cargo body, generally gave higher (a few feet) than the average roof cab. The flat, projecting front face of a cargo body is a strong source of drag on the cab roof. The use of the front-mounted aerodynamic fairings in recent years have served to significantly lower drag and, therefore, raise fuel economy for trucks, especially those traveling at high speed in the open roads.

Our analysis of this patent is as follows:

Stemco Lp’s patent US 9440689 B1 deals with Aerodynamic structures secured to the underbody of cargo bodies.
A flight underbody fairing or skirt that is attached to the rear wheels or bogeys in a cargo truck bodies generally can be slidably adjusted fore and aft along the cargo body. The various embodiments allow for a skirt that attaches bogeys in a cargo truck body and given back to the plane behind the trailer, and a retractable nature to allow for slidable change bogeys fore and aft along the cargo body for the purpose of continuing streamlined flow along the side of a cargo truck body equipped with a side of the border before the bogeys. In various embodiments of the invention, the retractable nature of the invention allows for a continuous edge surface of the plane with the side of the truck cargo bodies came from the back bogeys truck cargo plane body, without attention bogey position.

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Rear-mounted retractable aerodynamic structure for cargo bodies

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The Stemco Lp patent solves the following problem:

Trucking is the primary means of long-distance and short-haul transportation of goods and materials in the United States, and in many other countries. Trucks often include a motorized cab where the driver sits and working on cars. cab attached to a box-like cargo section. Smaller trucks often include an integrated cargo section sitting in a unified framework which extends from the front wheels to the rear wheel assembly. The larger trucks often includes a detachable cab unit, with many driven axles, and a special trailer with a long box-like cargo units served on two or more phrases assemblies wheels. These trucks assemblages commonly called semi-trailers or tractor trailers. Most modern trucks' cabs, especially for tractor trailers, fitted with aerodynamic fairings on the roof, side and front. These fairings to help direct air over the exposed surface of the box-like cargo body, generally gave higher (a few feet) than the average roof cab. The flat, projecting front face of a cargo body is a strong source of drag on the cab roof. The use of the front-mounted aerodynamic fairings in recent years have served to significantly lower drag and, therefore, raise fuel economy for trucks, especially those traveling at high speed in the open roads.

Our analysis of this patent is as follows:

Stemco Lp’s patent US 9440688 B2 deals with Rear-mounted retractable aerodynamic structure for cargo bodies.
A flying structure attached to the sides and the top of a truck cargo body (even in a stand-alone trailer or a straight truck cab and cargo area as a fixed the car) aftmost region, often involving a rolling door assembly, rolls upwardly. A navigational structure is permanently attached to the sides and on the trailer in a way that extend past the aftmost truck cargo plane body and withdrawal aftmost truck cargo plane body when subjected to a force, allowing the device to be supported by the structure. Redeems orientation allows for the back of the trailer to be fully accessible for loading and unloading, and does not reduce the size of the opening of the trailer. The various embodiments of the invention allows for automated deployment once the force used to compress the structure to be taken.

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