Substituted diazine and triazine spleen tyrosine kinease (Syk) inhibitors

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The Merck Sharp & Dohme Corp. patent solves the following problem:

Spleen Tyrosine Kinase (SYK) is a protein tyrosine kinase described as a key mediator of immunoreceptor signaling a host of inflammatory cells including mast cells, B-cells, macrophages and neutrophils. These immunoreceptors, including Fc receptor and the B-cell receptor, is important for allergic diseases, and antibody-mediated autoimmune diseases and thus pharmacologically interfering SYK conceivably treat these diseases.

Our analysis of this patent is as follows:

Merck Sharp & Dohme Corp.’s patent US 9416111 B2 deals with Substituted diazine and triazine spleen tyrosine kinease (Syk) inhibitors.
invention provides certain substituted diazine and triazine compounds of Formula (I) (I) or pharmaceutically acceptable salts thereof, wherein R1, R2, P3, R4, rcy, CY, and t as described here. invention also provides pharmaceutical compositions comprising such compounds, and methods of using the compounds for treating diseases or conditions mediated spleen tyrosine kinase (SYK) kinase.

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Aerodynamic device for the rear of a trailer

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The Trailstar International, Inc. patent solves the following problem:

The present invention relates generally to the field of aerodynamic devices to reduce drag. Particularly, the present invention relates to a flying device adapted to extend from the back of a trailer or semi-trailer container. In particular, the present invention relates to an air intake scoop and an inflatable member extending outwardly from a trailer.

Our analysis of this patent is as follows:

Trailstar International, Inc.’s patent US 9371097 B1 deals with Aerodynamic device for the rear of a trailer.
A flying device for a trailer includes an inflatable member with a back wall of a trailer adapted to inflate its rearwardly to reduce drag as the trailer pulled forwardly. The flying device further includes an air intake scoop mounted under the rear wall of the trailer in fluid communication with inflatable member filling the inflatable member in the air as the trailer moves forward.

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High energy liquid enteral nutritional composition

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The N.V. Nutricia patent solves the following problem:

The present invention relates in general to a liquid enteral composition for providing nutrition, or as a supplement, or as a complete nutrition, with a high energy inside.

Our analysis of this patent is as follows:

N.V. Nutricia’s patent US 9345256 B2 deals with High energy liquid enteral nutritional composition.
High energy and high protein liquid nutrition enteral composition which includes micellar casein and caseinate, a optionally a small amount of whey.

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Aminopyrimidines as Syk inhibitors

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The Merck Sharp & Dohme Corp. patent solves the following problem:

Spleen Tyrosine Kinase (SYK) is a protein tyrosine kinase described as a key mediator of immunoreceptor signaling a host of inflammatory cells including mast cells, B-cells, macrophages and neutrophils. These immunoreceptors, including Fc receptor and the B-cell receptor, is important for allergic diseases, and antibody-mediated autoimmune diseases and thus, pharmacologically interfering with SYK conceivably treat these diseases.

Our analysis of this patent is as follows:

Merck Sharp & Dohme Corp.’s patent US 9290490 B2 deals with Aminopyrimidines as Syk inhibitors.
The present invention provides new pyrimidine amines of formula I are potent inhibitor of spleen tyrosine kinase, and is useful in the treatment and prevention of diseases mediated by said enzyme, such as asthma, COPD, rheumatoid arthritis and cancer.

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Methods for promoting neuronal development and/or health

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The Mead Johnson Nutrition Company patent solves the following problem:

The brain has only 2% of the total weight of the body, but it is a difficult organ used in 30% of calories in the day and nutrients. (Harris, JJ et al, The Energetics of CNS White Matter jour Neuroscience, January 2012: 32 (1): 356-371). The human brain and nervous system begin construction early in prenatal life and the two continue to develop until the age of three. This early development may have lifelong effects on overall brain and nervous system health. Therefore, brain nutrients become important additives in the diet of infants, children and pregnant and lactating women because of their ability to improve early brain development and the prevention and protection from brain and nervous system injury or illness. Moreover, brain nutrition is important for adults, as many nutrients to the developing nervous system to repair and provide neuroprotective benefits to health.

Our analysis of this patent is as follows:

Mead Johnson Nutrition Company’s patent US 9241923 B2 deals with Methods for promoting neuronal development and/or health.
The present disclosure is directed to methods for improving neuronal health and / or development of a subject by providing nutritional composition comprising a neurologic component, wherein the neurologic component to develop the brain and nervous system development and further provide neurological protection and repair. The neurologic component may include lactoferrin, zinc sulfate, one or more organosulfur compounds, and mixtures thereof.

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Wear and friction properties of engineering thermoplastics with ultra-high molecular weight polyethylene

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The Sabic Global Technologies B.V. patent solves the following problem:

Ultra-high molecular weight polyethylene (UHMWPE) has a very high melt viscosity that makes conventional processing techniques such as screw extrusion and injection molding difficult to fulfill. Thus, the use of UHMWPE limited. Polyetherimide (PEI), and polyetheretherketone (Peek) is used in a variety of lubricated applications such as gears, bearings, and rollers, for example.

Our analysis of this patent is as follows:

Sabic Global Technologies B.V.’s patent US 9181430 B2 deals with Wear and friction properties of engineering thermoplastics with ultra-high molecular weight polyethylene.
Said here is the composition comprising a polymer comprising polyetherimide, polyetheretherketone, polyamide, polyoxyalkylene or polyalkylene terephthalate, or a mixture thereof, and ultra-high molecular weight polyethylene, where the ultra- high molecular weight polyethylene covers a surface modifier. Also disclosed are articles containing one or more of the species composition. abstract It is intended as a scanning tool for purposes of searching in the particular art and is not intended to limit the present invention.

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Portrait dual display and landscape dual display

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The Z124 patent solves the following problem:

A substantial number of handheld devices Computing, such as cellular phones, tablets, and E-Readers, make use of a touch screen display will not only save the display information to the user, but also to take inputs from the user's command interface. While touch screen display can increase the configurability of the handheld device and to provide a wide variety of user interface options, this flexibility often comes at a price. The two use the touch screen to provide for and receive user commands, while flexible for the user, in order to obfuscate the display, and cause visual clutter, thus leading to user frustration and loss of yield.

Our analysis of this patent is as follows:

Z124’s patent US 9152179 B2 deals with Portrait dual display and landscape dual display.
Methods and devices for controlling the output shown associated with the application in connection with a large screen device given. Particularly, an application presented to the devices in a two-picture orientation used the first screen to display the control information, and use the second screen to show the inside information. An application presented to the creation of a two landscape orientation use the first screen and the second screen to show the inside information.

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Dual display pinyin touch input

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The Z124 patent solves the following problem:

A substantial number of handheld devices Computing, such as cellular phones, tablets, and E-Readers, make use of a touch screen display will not only save the display information to the user, but also to take inputs from the user's command interface. While touch screen display can increase the configurability of the handheld device and to provide a wide variety of user interface options, this flexibility often comes at a price. The two use the touch screen to provide for and receive user commands, while flexible for the user, in order to obfuscate the display, and cause visual clutter, thus leading to user frustration and loss of yield.

Our analysis of this patent is as follows:

Z124’s patent US 9128660 B2 deals with Dual display pinyin touch input.
These methods and devices including providing a device having at least a first screen and a secondary screen; receiving a first input, where the first input comprising a Pinyin input on the first screen; processing the first input to estimate a character based on previous input; to display the estimated character (s); and to exercise a choice, where the selection includes a choice of traits selected from the estimated character (s).

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Determining usefulness of a data alert

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The Domo, Inc. patent solves the following problem:

Our analysis of this patent is as follows:

Domo, Inc.’s patent US 9082282 B1 deals with Determining usefulness of a data alert.
An alert to provide a user notification when a cause that situation regarding the operation of a business that satisfied. Before making the alert, a proposed trigger alert conditions can be received. The trigger conditions can be compared to a database of operational data related to business operations over a period of time to obtain the historical data purposes. The historical data in the vise may indicate how the proposed alert would work if applied to the operational data for the period of time, for example, by showing how the many times the alert may be triggered during the period of the season. The historical data in the vise can be given to a user, and facilitate user determination if the proposed alert will perform as intended. Once the desired proposed alert entered, user can put the proposed alert as a real alert.

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Endpoint-hosted hypervisor management

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The International Business Machines Corporation patent solves the following problem:

The invention relates to the electronic network. Particularly, the invention relates to the endpoint host hypervisor management.

Our analysis of this patent is as follows:

International Business Machines Corporation’s patent US 9055386 B2 deals with Endpoint-hosted hypervisor management.
A client hypervisor consists of a virtual agent that runs out of a system of the OS, and that allows to manage devices independent of the OS and the user. The virtual agents tied to one device and not to a specific time of the OS. Such client hypervisors expose new functionality to ease system management. Some of these capabilities from endurance and privileges without the OS. In some embodiments of the invention, this new management functionality to spread the rule of the device with new virtualization concepts, such as the number of VMs per system, VM instead, snapshot / rollback, etc.

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