Polymorphic crystal forms of 5-(2-{[6-(2,2-difluoro-2-phenylethoxy)hexyl]amino}-1-(R)-hydroxyethyl)-8-hydroxyquinolin-2(1H)-one, heminapadisytlate as agonist of the 2 adrenergic receptor

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The Almirall, S.A. patent solves the following problem:

5- (2 – {[6- (2,2-difluoro-2-phenylethoxy) hexyl] amino} -1 (R) -hydroxyethyl) -8-hydroxyquinolin-2 (1H) -one (Compound I) is a valiant 2 adrenoceptor agonist first disclosed in WO 2006/122788. This compound of the following chemical formula.

Our analysis of this patent is as follows:

Almirall, S.A.’s patent US 9346759 B2 deals with Polymorphic crystal forms of 5-(2-{[6-(2,2-difluoro-2-phenylethoxy)hexyl]amino}-1-(R)-hydroxyethyl)-8-hydroxyquinolin-2(1H)-one, heminapadisytlate as agonist of the 2 adrenergic receptor.
The present invention is directed to novel polymorphic crystalline form of a 5- (2 – {[6- (2,2-difluoro-2-phenylethoxy) hexyl] amino} -1- (R) -hydroxyethyl) -8-hydroxyquinolin- 2 (1H) -one, heminapadisylate. invention is also directed to pharmaceutical compositions comprising said polymorphic crystalline forms, ways to use them to treat respiratory diseases associated with 2 adrenergic receptor activity and a process to prepare the polymorphic crystalline forms.

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Halogen-free, fireproof, transparent thermoplastic compositions having high thermomechanical strength, in particular for encapsulation in photovoltaic modules

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The Arkema France patent solves the following problem:

Our analysis of this patent is as follows:

Arkema France’s patent US 9331215 B2 deals with Halogen-free, fireproof, transparent thermoplastic compositions having high thermomechanical strength, in particular for encapsulation in photovoltaic modules.
A transparent, fireproof thermoplastic composition which is free from halogen compounds and include a polyamide-block graft copolymer formed a polyolefin backbone and, on average, at least one polyamide graft. The grafts attached to the backbone by the radicals of an unsaturated monomer (X) has a function able to react in a polyamide, and the radicals of the unsaturated monomer (X) is attached to the roots the backbone by grafting or co-polymerisation of the double bond. composition includes, as a weight percentage of the total composition: 90 to 99 wt% of polyamide-block graft copolymer, and 1 to 10 wt% of metal salts of phosphoric acid.

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Non-digestible oligosaccharides for oral induction of tolerance against dietary proteins

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The N.V. Nutricia patent solves the following problem:

During the common process of nutrition in food proteins presented to the immune system through the gastro-intestinal tract without an immune response to ingested nutrients. This unresponsiveness is called oral immune tolerance or oral tolerance. The induction of oral immune tolerance is especially relevant for children, after being exposed for the first time to eat protein and adapt to it. If the children's oral immune tolerance is established, food allergies occur. The people who suffer from food allergies requires a specific food protein food to avoid.

Our analysis of this patent is as follows:

N.V. Nutricia’s patent US 9060996 B2 deals with Non-digestible oligosaccharides for oral induction of tolerance against dietary proteins.
Composition and the manner in which the child nutrition partially hydrolysed protein and non-digestible oligosaccharides for use in the induction of oral tolerance against the native of dietary protein.

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Vehicle fuel economy system

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The StormBlok Systems, Inc. patent solves the following problem:

Now most tractor-trailers and about 6-7 mpg fuel leaving significant potential for improving fuel economy of tractor-trailers. Reduced fuel consumption of tractor-trailers that directly impact cost of transportation of goods, serving businesses and consumers alike.

Our analysis of this patent is as follows:

StormBlok Systems, Inc.’s patent US 8985677 B2 deals with Vehicle fuel economy system.
A fairing assembly for a trailer with a wheel set and a hook, the fairing assembly consisting of a fairing connected to an underside of the trailer intermediate hooks, and the wheels set, the fairing including (i) a pair of opposing lateral surfaces separated by a distance, (ii) a lower surface spaced from the underside of the trailer, and (ii) a first face, the first face substantially spanning the distance, where the first face includes an intake opening, wherein at least one of the lower face or the lateral surfaces include an exit opening, and a flow path fluidly connecting the intake openings and exit openings.

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System and method for policy based management for a high security MANET

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The Telcordia Technologies, Inc. patent solves the following problem:

With the development of more complex systems, policies widely used to allow users a level of customization and automation in one system without the need for rebuilding or starting back . Existing policy-based management system (PBNM or PBMS) indicates dry for access control, compulsory nature, and / or flow control, but would not address security architecture. Most existing system policy to a centralized approach to security and described the centralized policy control, where the security given to the network authentication process, although some may use the authentication information as part of state policy. Often, the connectivity and dependence on beliefs, allowing the deployment of a centralized or hierarchical system for the distribution and evaluation of policies. Typically, a trusted node is believed to be PBNM. However, any node in the network to be a noticeable attacker.

Our analysis of this patent is as follows:

Telcordia Technologies, Inc.’s patent US 8769068 B2 deals with System and method for policy based management for a high security MANET.
A system and method for policy-based management for a long MANET security policy covering managers, each one to make policy decisions and policy implementation of many policies, vessels, each one related to an application and each vessel has a policy manager, nodes, each with an infrastructure and at least one vessel, and dynamic community building blocks to make the vessels with a such application, the vessel in different nodes, the related vessels maintained by the dynamic community building blocks of a strong network. Each vessel can define a security boundary around the node. Each vessel will be a lightweight virtual machine. The system may also have a special container with a policy manager evaluate the policies for fighting. In one picture, a node may include many devices network and every network device is a vessel himself.

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Sulfonamide compounds for the treatment of respiratory disorders

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The Pulmagen Theraputics (Inflammation) Limited patent solves the following problem:

A broad spectrum of respiratory diseases and disorders recognized and many of which have overlapping and interacting etiologies. Two of the most common and widespread of these diseases are chronic obstructive pulmonary disorder (COPD) and asthma. Respiratory diseases have a significant inflammatory component. For example, the current therapy for COPD and asthma focused mainly on reducing symptoms in short and long acting bronchodilators either as monotherapies or in combination with long-acting 2 agonist bronchodilators with inhaled corticosteroids (ICS ).

Our analysis of this patent is as follows:

Pulmagen Theraputics (Inflammation) Limited’s patent US 8362064 B2 deals with Sulfonamide compounds for the treatment of respiratory disorders.
Compounds of formula (I) are agonists of PPAR, useful for the treatment of respiratory diseases; formula (I): wherein R1, R2 or P3 each independently represents halo, cyano, nitro, amino, alkyl, haloalkyl, alkoxy, haloalkoxy, carboxylic acid or an ester or amide thereof; R4 represents hydrogen or alkyl; m, nop independently represents 0, 1, 2 or 3.

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Devices and methods for reducing vehicle drag

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The SmartTruckSystems, LLC patent solves the following problem:

An ongoing effort to reduce the drag in vehicular structures is of great importance as the fuel economy will be a greater consideration in vehicular design. As the drag of a car increases, the amount of fuel needed to move vehicles also increased because of greater energy required to overcome drag. For example, it states that for a vehicle traveling at 70 mph, 65% of the total fuel consumption of the engine of the car used to overcome drag. Therefore, even a small reduction in drag experienced by a vehicle traveling at a speed of course would result in a significant improvement in fuel economy.

Our analysis of this patent is as follows:

SmartTruckSystems, LLC’s patent US 8342595 B2 deals with Devices and methods for reducing vehicle drag.
An apparatus for reducing drag in a trailer provided. The apparatus may further include a pair of fairings configured positions on opposite sides of a trailer in front of the wheels under a trailer, a pair of fairings configured positions on opposite sides in a trailer behind the wheel under a trailer, with two pairs of fairings placed and shaped to direct the air smoothly around the wheels and wheel and through the center of the trailer. The apparatus may also include a ramp in front of the suspension components, aerodynamically shaped wings on the axles, and a rear diffuser, these components are configured to direct air orderly among the trailer suspension and the earth. The high command of the wind energy from facilities results in a reduction in trailer base drag.

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Intestinal barrier integrity

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The N. V. Nutricia patent solves the following problem:

The stomach epithelium often acts as a barrier authority chose the absorption of nutrients, electrolytes and water and preventing the exposure to dietary and microbial antigens, including food allergens. The stomach epithelium limits the passage of antigens to the systemic circulation, which can cause inflammatory reactions, such as allergic reactions. As the incidence of allergies, especially food allergies is increasing, many research groups search for (preventive) cures for these diseases.

Our analysis of this patent is as follows:

N. V. Nutricia’s patent US 8252769 B2 deals with Intestinal barrier integrity.
the invention of a method for stimulating barrier integrity in a mammal by administering to a mammal a composition comprising: eicosapentaenoic acid (EPA), docosahexacnoic acid (DHA) and arachidonic acid (ARA), and at least two different oligosaccharides.

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Prebiotic compositions

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The Nestec S.A. patent solves the following problem:

Our analysis of this patent is as follows:

Nestec S.A.’s patent US 8241658 B2 deals with Prebiotic compositions.
The present invention concerns nutritional composition containing oligosaccharides for controlling inflammatory bowel disease and related diseases, such as diarrhea and constipation.

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Mobile terminal apparatus and software install method

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The Fujitsu Limited patent solves the following problem:

The present invention relates to a technology for installing software on a mobile terminal equipment of a peripheral device to be connected.

Our analysis of this patent is as follows:

Fujitsu Limited’s patent US 7761883 B2 deals with Mobile terminal apparatus and software install method.
A unit-source monitoring software monitors a software source that provides software needed for use with peripheral devices, and store data about acquirable software and software source in a corresponding manner to a unit memory. A unit of peripheral-device monitoring monitor connection status of peripheral devices. A software-source selecting unit selects the software source based on data stored in the memory unit when the unit peripheral-device monitoring detects the connection of peripheral devices. An installation discharge unit acquires software from source software chosen by the selection unit-source software.

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