Substituted diazine and triazine spleen tyrosine kinease (Syk) inhibitors

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The Merck Sharp & Dohme Corp. patent solves the following problem:

Spleen Tyrosine Kinase (SYK) is a protein tyrosine kinase described as a key mediator of immunoreceptor signaling a host of inflammatory cells including mast cells, B-cells, macrophages and neutrophils. These immunoreceptors, including Fc receptor and the B-cell receptor, is important for allergic diseases, and antibody-mediated autoimmune diseases and thus pharmacologically interfering SYK conceivably treat these diseases.

Our analysis of this patent is as follows:

Merck Sharp & Dohme Corp.’s patent US 9416111 B2 deals with Substituted diazine and triazine spleen tyrosine kinease (Syk) inhibitors.
invention provides certain substituted diazine and triazine compounds of Formula (I) (I) or pharmaceutically acceptable salts thereof, wherein R1, R2, P3, R4, rcy, CY, and t as described here. invention also provides pharmaceutical compositions comprising such compounds, and methods of using the compounds for treating diseases or conditions mediated spleen tyrosine kinase (SYK) kinase.

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Information environment map

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The Domo, Inc. patent solves the following problem:

Our analysis of this patent is as follows:

Domo, Inc.’s patent US 9299170 B1 deals with Information environment map.
Information presented on a map like a map of the city, with the relevant information to different groups of neighborhoods. Such a display method takes advantage of spatial cognition to provide an organizational and presentational devices that users can more easily remember where to look and find the right information. Metadata, notifications, and / or other auxiliary information may be presented with or cast on the data itself.

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Aminopyrimidines as Syk inhibitors

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The Merck Sharp & Dohme Corp. patent solves the following problem:

Spleen Tyrosine Kinase (SYK) is a protein tyrosine kinase described as a key mediator of immunoreceptor signaling a host of inflammatory cells including mast cells, B-cells, macrophages and neutrophils. These immunoreceptors, including Fc receptor and the B-cell receptor, is important for allergic diseases, and antibody-mediated autoimmune diseases and thus, pharmacologically interfering with SYK conceivably treat these diseases.

Our analysis of this patent is as follows:

Merck Sharp & Dohme Corp.’s patent US 9290490 B2 deals with Aminopyrimidines as Syk inhibitors.
The present invention provides new pyrimidine amines of formula I are potent inhibitor of spleen tyrosine kinase, and is useful in the treatment and prevention of diseases mediated by said enzyme, such as asthma, COPD, rheumatoid arthritis and cancer.

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Dosage and formulation

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The Almirall, S.A. patent solves the following problem:

Aclidinium bromide is 3 (R) – (2-hydroxy-2,2-dithien-2-ylacetoxy) -1- (3-phenoxypropyl) -1-azoniabicyclo [2.2.2] octane bromide, described in, for example WO 0104118. Although this compound is known as a long-acting anticholinergic useful in the treatment of respiratory diseases, the optimal dose was not disclosed.

Our analysis of this patent is as follows:

Almirall, S.A.’s patent US 9254262 B2 deals with Dosage and formulation.
The present disclosure relates to pharmaceutical compositions for inhalation comprising aclidinium in the form of a dry powder in a pharmaceutically acceptable salt in admixture with a pharmaceutically acceptable dry powder carrier, providing a metered nominal dose of aclidinium equivalent to about 200 micrograms aclidinium bromide.

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Automated suggested alerts based on natural language and user profile analysis

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The Domo, Inc. patent solves the following problem:

Our analysis of this patent is as follows:

Domo, Inc.’s patent US 9235978 B1 deals with Automated suggested alerts based on natural language and user profile analysis.
An alert suggestion generator to automatically suggest alert for a user based on user input. The user input may include natural language text and / or user actions that suggestion generator able to generate alert that there is a high tendency to relate, and therefore will, to the user. Each alert will have a reason for existence as the passage of time, the measure of a numeric metric, or other factors. Each alert also has a state proclamation clear how the user is announced. The alert suggestion generator to get a user profile of the user in addition to determining how alert that is most relevant to the user. The user will be queried to confirm the alert, and the alert that they set. Partial alarm will be generated and user can be queried for the trigger condition and / or state announcement needed to complete the alert.

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Automatic web service monitoring

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The Domo, Inc. patent solves the following problem:

Our analysis of this patent is as follows:

Domo, Inc.’s patent US 9191285 B1 deals with Automatic web service monitoring.
According to various embodiments, the present invention provides a live site performance monitoring in the context of reasonable resource hierarchies found in cloud computing systems. In particular, in an image, the system of the present invention facilitates monitoring of new services Computing without necessarily requires clear knowledge of these new services. Such services may include, for example and without limitation, given the use of an image that State Transfer (REST) ​​architecture, although the techniques described herein may also be used in other architectures. In one embodiment, the system of the present invention works by automatically creating groups of things for performance monitoring, based on the hierarchy of a type. Heuristics can be used to determine aggregatable hierarchy nodes.

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Presentation of document history in a web browsing application

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The Domo, Inc. patent solves the following problem:

Electronic user devices able to work with an ever-growing number of types of documents and projects online. Users can access documents, hosted application providers online, from their electronic devices, often through a web browsing application. Google Docs, Microsoft Office Live, collaborative internetlintranet website like pages, and others, are examples of services that allows users to make various kinds of documents (eg word processing, spreadsheets, presentations, etc.) online and invite other people to revise these documents away. Changes to a document that the user is captured in the form of document revision. A user can access a shared online documents, to see the various states in the document, which a state (also referred to as a revision) in a document may include changes made by other users. The changes mostly delineated in different colors, fonts, formatting, little signs, etc.

Our analysis of this patent is as follows:

Domo, Inc.’s patent US 9135228 B2 deals with Presentation of document history in a web browsing application.
In a joint computing environment, a method and system for displaying revision associated with a host of electronic document states. According to the disclosed methods and systems, selected revision to an electronic document to be shown to a user, an aviation visual history play back the evolution of electronic documents. The electronic document can be displayed in a web browsing application, using a Document Object Model (DOM) to recover the selected revision with Asynchronous JavaScript and XML (Ajax) calls to a remote device / server.

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Fiber for synthetic grass field

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The Tarkett Inc. patent solves the following problem:

Artificial grass fields (artificial turf) used for years to provide a surface that simulates natural grass. These artificial grass field there are many benefits to natural grass, and, moreover, can be installed and used in places that do not allow for natural grass fields.

Our analysis of this patent is as follows:

Tarkett Inc.’s patent US 9005723 B2 deals with Fiber for synthetic grass field.
A filament for use in an artificial grass field, where the filament has a front and a rear face and at least one of the front face and rear face includes a number of neighboring concave indentations gave general -from a first end to a second end.

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Pea protein peptides with anti Helicobacter pylori activity

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The N.V. Nutricia patent solves the following problem:

Abdominal infections are a major problem for many people, and especially children and patients with an impaired immune system or abdominal pain. The result of the disease can be fatal. Stomach infection often caused by Escherichia coli, Salmonella, Campylobacter, Porphyromonas gingivalis, Clostridium, Enterobacter and Helicobacter, such as Helicobacter pylori.

Our analysis of this patent is as follows:

N.V. Nutricia’s patent US 8999924 B2 deals with Pea protein peptides with anti Helicobacter pylori activity.
The invention relates to a composition comprising pea protein hydrolyzate for the treatment and / or prevention of infection in the stomach pathogens, in particular Helicobacter pylori and / or a disease associated with infection of the stomach pathogen in said mammal.

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Nutritional compositions with coated lipid globules

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The N. V. Nutricia patent solves the following problem:

Breast-feeding is the preferred method of infant feeding. However, there are circumstances that make breast-feeding impossible or less attractive. In the case of children's formula is a good alternative. The composition of modern infant formulas is adapted in such a way that will meet many of the special nutritional needs of the fast growing and developing infant.

Our analysis of this patent is as follows:

N. V. Nutricia’s patent US 8883219 B2 deals with Nutritional compositions with coated lipid globules.
The present invention relates to a nutritional composition for children and / or children consisting of a lipid component has a lipid globules coated with phospholipids. composition used for increasing bone mineral content, bone mineral density, prevent osteoporosis, and / or control ostopenia.

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