Polymorphic crystal forms of 5-(2-{[6-(2,2-difluoro-2-phenylethoxy)hexyl]amino}-1-(R)-hydroxyethyl)-8-hydroxyquinolin-2(1H)-one, heminapadisytlate as agonist of the 2 adrenergic receptor

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The Almirall, S.A. patent solves the following problem:

5- (2 – {[6- (2,2-difluoro-2-phenylethoxy) hexyl] amino} -1 (R) -hydroxyethyl) -8-hydroxyquinolin-2 (1H) -one (Compound I) is a valiant 2 adrenoceptor agonist first disclosed in WO 2006/122788. This compound of the following chemical formula.

Our analysis of this patent is as follows:

Almirall, S.A.’s patent US 9346759 B2 deals with Polymorphic crystal forms of 5-(2-{[6-(2,2-difluoro-2-phenylethoxy)hexyl]amino}-1-(R)-hydroxyethyl)-8-hydroxyquinolin-2(1H)-one, heminapadisytlate as agonist of the 2 adrenergic receptor.
The present invention is directed to novel polymorphic crystalline form of a 5- (2 – {[6- (2,2-difluoro-2-phenylethoxy) hexyl] amino} -1- (R) -hydroxyethyl) -8-hydroxyquinolin- 2 (1H) -one, heminapadisylate. invention is also directed to pharmaceutical compositions comprising said polymorphic crystalline forms, ways to use them to treat respiratory diseases associated with 2 adrenergic receptor activity and a process to prepare the polymorphic crystalline forms.

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Dry powder pharmaceutical composition for inhalation

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The Daiichi Sankyo Company, Limited patent solves the following problem:

Japanese Patent No. 3209946 (Patent Document 1) discloses compounds with neuraminidase inhibitory activity, including the compound represented by formula (I) shown below. The compound represented by formula (I) have excellent neuraminidase inhibitory activity and is expected to be useful as a drug for treating and preventing influenza virus infection. Japanese Patent No. 4205314 (Patent Document 2) revealed a concentration of the compound represented by formula (I) can remain on for a long time in the respiratory tissues like lung (Patent Document 2).

Our analysis of this patent is as follows:

Daiichi Sankyo Company, Limited’s patent US 9339487 B2 deals with Dry powder pharmaceutical composition for inhalation.
There was a dry powder pharmaceutical composition for inhalation is useful for preventing and / or treating influenza virus infections included as a medicinal component of a compound represented by formula (I): and optionally a compound represented by formula (II): a pharmacologically acceptable salt thereof, or a hydrate thereof.

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Halogen-free, fireproof, transparent thermoplastic compositions having high thermomechanical strength, in particular for encapsulation in photovoltaic modules

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The Arkema France patent solves the following problem:

Our analysis of this patent is as follows:

Arkema France’s patent US 9331215 B2 deals with Halogen-free, fireproof, transparent thermoplastic compositions having high thermomechanical strength, in particular for encapsulation in photovoltaic modules.
A transparent, fireproof thermoplastic composition which is free from halogen compounds and include a polyamide-block graft copolymer formed a polyolefin backbone and, on average, at least one polyamide graft. The grafts attached to the backbone by the radicals of an unsaturated monomer (X) has a function able to react in a polyamide, and the radicals of the unsaturated monomer (X) is attached to the roots the backbone by grafting or co-polymerisation of the double bond. composition includes, as a weight percentage of the total composition: 90 to 99 wt% of polyamide-block graft copolymer, and 1 to 10 wt% of metal salts of phosphoric acid.

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Nutritional composition with probiotics

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The N.V. Nutricia patent solves the following problem:

Infants without intestinal flora at birth. As a result of contact with the mother during birth and subsequent feeding with human milk or formula milk, the intestinal flora rapidly. During the development, the intestinal flora is still immature and normal activities are weak. Human milk-fed infants are less afflicted by infections or diseases than formula-fed infants. Thus, human milk-fed children have less gastro-intestinal infections in terms of incidents and the duration, less atopic diseases such as allergies, eczema, less colics and cramps, and less constipation than formula-fed infants. pain came later in life, such as childhood obesity, diabetes, and asthma are related to the kind of feeding during the early stages of life, with human milk-fed infants for good .

Our analysis of this patent is as follows:

N.V. Nutricia’s patent US 9314047 B2 deals with Nutritional composition with probiotics.
A composition comprising Bifidobacterium breve, a non-digestible saccharide A and a non-digestible saccharide B, optionally with Lactobacillus paracasei and the use of said composition for the treatment and / or prevention of gastro-intestinal disorders, immune disorder and / or endocrine disorder.

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Composition for flexible membranes

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The Sika Technology Ag patent solves the following problem:

Our analysis of this patent is as follows:

Sika Technology Ag’s patent US 9309400 B2 deals with Composition for flexible membranes.
A composition including a styrene block copolymer, a polar-modified styrene block copolymer, plant fibers and a polyolefin strong at 25 C., and the molten body, especially the membranes, made from such compositions.

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Chemoenzymatic synthesis of heparin and heparan sulfate analogs

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The The Regents Of The University Of California patent solves the following problem:

Our analysis of this patent is as follows:

The Regents Of The University Of California’s patent US 9290530 B2 deals with Chemoenzymatic synthesis of heparin and heparan sulfate analogs.
The present invention provides a one-pot multi-enzyme method for preparing the UDP-sugars from simple sugar starting materials. invention also provides a one-pot multi-enzyme process for the preparation of oligosaccharides from simple sugar starting materials.

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Air fairing for frameless trailer

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The Mac Trailer Manufacturing, Inc. patent solves the following problem:

The present invention relates generally to systems and devices that increase aerodynamic efficiency. Particularly, the invention relates generally to a wind fairing or trailer skirts on trailers. In particular, the invention relates to an air fairing for a frameless trailer.

Our analysis of this patent is as follows:

Mac Trailer Manufacturing, Inc.’s patent US 9283998 B2 deals with Air fairing for frameless trailer.
An air fairing device connected to the bottom under a frameless trailer improve flight efficiency and improve fuel economy. A picture of the wind fairing device provides a wind deflector position ahead of a trolley that supports the frameless trailer on a back end. The second image in the air fairing device provides two things mounted under the frameless trailer. The first deflector is attached and handed down from one sustain arm, said arm connecting the trailer of a semi-tractor or truck. The second deflector connected below the bottom of the frameless trailer and positioned behind the first deflector and the side of the trolley. A third image is similar to the second, but further includes a third deflector positioned between the two axles of the trolley.

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Method for initiating a consumable-based cycle of operation

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The Whirlpool Corportion patent solves the following problem:

The invention relates to the use of consumables through a communication device on a network creatures, and especially, the choice of appliance from a plurality of appliances that have an event associated with consumable.

Our analysis of this patent is as follows:

Whirlpool Corportion’s patent US 9277188 B2 deals with Method for initiating a consumable-based cycle of operation.
One way to start a cycle of operation based on a consumable includes providing a consumable reader with a software architecture configured to image data, talk on the one network, and recognition functionalities of appliances based on a unique identification associated with each time a functionality, imaging data of the consumable use consumable reader; Taking cycle data associated with the consumable based on imaged data; know, the software architecture in at least one activity associated with the data cycle; selecting from the plurality of appliances is an appliance with at least one activity using the unique identifier associated with a time of at least one event; and communicating the data cycle to the selected appliance on the network the appliances where the selected appliance becomes a cycle of operation associated with the consumable usage data cycle.

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Dosage and formulation

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The Almirall, S.A. patent solves the following problem:

Aclidinium bromide is 3 (R) – (2-hydroxy-2,2-dithien-2-ylacetoxy) -1- (3-phenoxypropyl) -1-azoniabicyclo [2.2.2] octane bromide, described in, for example WO 0104118. Although this compound is known as a long-acting anticholinergic useful in the treatment of respiratory diseases, the optimal dose was not disclosed.

Our analysis of this patent is as follows:

Almirall, S.A.’s patent US 9254262 B2 deals with Dosage and formulation.
The present disclosure relates to pharmaceutical compositions for inhalation comprising aclidinium in the form of a dry powder in a pharmaceutically acceptable salt in admixture with a pharmaceutically acceptable dry powder carrier, providing a metered nominal dose of aclidinium equivalent to about 200 micrograms aclidinium bromide.

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Methods for promoting neuronal development and/or health

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The Mead Johnson Nutrition Company patent solves the following problem:

The brain has only 2% of the total weight of the body, but it is a difficult organ used in 30% of calories in the day and nutrients. (Harris, JJ et al, The Energetics of CNS White Matter jour Neuroscience, January 2012: 32 (1): 356-371). The human brain and nervous system begin construction early in prenatal life and the two continue to develop until the age of three. This early development may have lifelong effects on overall brain and nervous system health. Therefore, brain nutrients become important additives in the diet of infants, children and pregnant and lactating women because of their ability to improve early brain development and the prevention and protection from brain and nervous system injury or illness. Moreover, brain nutrition is important for adults, as many nutrients to the developing nervous system to repair and provide neuroprotective benefits to health.

Our analysis of this patent is as follows:

Mead Johnson Nutrition Company’s patent US 9241923 B2 deals with Methods for promoting neuronal development and/or health.
The present disclosure is directed to methods for improving neuronal health and / or development of a subject by providing nutritional composition comprising a neurologic component, wherein the neurologic component to develop the brain and nervous system development and further provide neurological protection and repair. The neurologic component may include lactoferrin, zinc sulfate, one or more organosulfur compounds, and mixtures thereof.

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