BTK inhibitors

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The Merck Sharp & Dohme Corp. patent solves the following problem:

B lymphocyte activation is key to the generation of adaptive immune responses. Derailed B lymphocyte activation is a sign of many autoimmune diseases and in the modulation of the immune response and therapeutic interest. Recently the success of B cell therapy in autoimmune disease is established. Treatment of rheumatoid arthritis (RA) patients with Rituximab (anti-CD20 therapy) is an accepted clinical therapy today. More recent clinical trial studies showed that treatment with Rituximab also ameliorates symptoms of the disease in relapsing remitting multiple sclerosis (RRMS) and systemic lupus erythematosus (murder) patients. This success supports the potential for future therapies for autoimmune diseases targeted B cell immunity.

Our analysis of this patent is as follows:

Merck Sharp & Dohme Corp.’s patent US 9446130 B2 deals with BTK inhibitors.
The present invention provides Bruton's tyrosine kinase (Btk) inhibitor compounds according to Formula I or pharmaceutically acceptable salt thereof. Formula I or a pharmaceutically acceptable salt thereof or pharmaceutical compositions comprising these compounds and their use in therapy. In particular, the present invention relates to the use of Btk inhibitor compounds for the treatment of Btk mediated disorder.

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User interface with independent drawer control

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The Z124 patent solves the following problem:

While the computing and communications functions for handheld devices Computing becomes more powerful, the user interface and display elements such devices have evolved by trying to adapt user interface regime for the personal computer for use in handheld devices Computing . However, this attempt to adapt the user interface of the regime met with various obstacles.

Our analysis of this patent is as follows:

Z124’s patent US 9405444 B2 deals with User interface with independent drawer control.
Methods and apparatus for controlling the display of one or more drawers with a user interface to provide a new user interface interaction. The drawers can be opened in response to a motion input to display the data announcement, application data, contact data, calendar data, weather data, and the drawers can be opened and / or closed individually or collectively. For example, a character in action (eg, a place of action) may determine that the drawer was opened in response to the motion input.

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Ingredients for inhalation and methods for making the same

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The Vectura Limited patent solves the following problem:

Our analysis of this patent is as follows:

Vectura Limited’s patent US 9381189 B2 deals with Ingredients for inhalation and methods for making the same.
A method of processing an active ingredient, the method comprising submit a pharmaceutically active substances in excipients and / or additives to compression and shearing forces. The invention also relates to compositions comprising an active prepared by the procedure.

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Adjustable side under-ride guard for sliding axle trailer

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The Stephen Allen Batzer, , Patrick Keith Rogers patent solves the following problem:

The recognized hazard of side collision against dragged trailers traced at least back in 1938 that Robinson invented a peripheral guard for a hook-mounted trailer. See US Pat. No. 2,002,832. In his patent teaches a fixed whole periphery kept for a towed trailer with fixed rear axle. This non-regulated system to guard against the impact on the trailer from all directions.

Our analysis of this patent is as follows:

Stephen Allen Batzer, , Patrick Keith Rogers’s patent US 9352714 B2 deals with Adjustable side under-ride guard for sliding axle trailer.
A side under-ride collision guard described configured sitting in a large trailer equipped with a sliding rear axle, consisting of one or more energy absorbing structures cut wood axially adjustable for the position included in a multiplicity of similar barriers to diminish the impact hazard to other users paths presented lower axial edge (s) in the cargo compartment of the region (s) among the back the wheels of the trailer and the trailer back under-ride guard and / or between a stationary side under-ride guard and publicly trailer's wheels.

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Air fairing for frameless trailer

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The Mac Trailer Manufacturing, Inc. patent solves the following problem:

The present invention relates generally to systems and devices that increase aerodynamic efficiency. Particularly, the invention relates generally to a wind fairing or trailer skirts on trailers. In particular, the invention relates to an air fairing for a frameless trailer.

Our analysis of this patent is as follows:

Mac Trailer Manufacturing, Inc.’s patent US 9283998 B2 deals with Air fairing for frameless trailer.
An air fairing device connected to the bottom under a frameless trailer improve flight efficiency and improve fuel economy. A picture of the wind fairing device provides a wind deflector position ahead of a trolley that supports the frameless trailer on a back end. The second image in the air fairing device provides two things mounted under the frameless trailer. The first deflector is attached and handed down from one sustain arm, said arm connecting the trailer of a semi-tractor or truck. The second deflector connected below the bottom of the frameless trailer and positioned behind the first deflector and the side of the trolley. A third image is similar to the second, but further includes a third deflector positioned between the two axles of the trolley.

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Method for initiating a consumable-based cycle of operation

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The Whirlpool Corportion patent solves the following problem:

The invention relates to the use of consumables through a communication device on a network creatures, and especially, the choice of appliance from a plurality of appliances that have an event associated with consumable.

Our analysis of this patent is as follows:

Whirlpool Corportion’s patent US 9277188 B2 deals with Method for initiating a consumable-based cycle of operation.
One way to start a cycle of operation based on a consumable includes providing a consumable reader with a software architecture configured to image data, talk on the one network, and recognition functionalities of appliances based on a unique identification associated with each time a functionality, imaging data of the consumable use consumable reader; Taking cycle data associated with the consumable based on imaged data; know, the software architecture in at least one activity associated with the data cycle; selecting from the plurality of appliances is an appliance with at least one activity using the unique identifier associated with a time of at least one event; and communicating the data cycle to the selected appliance on the network the appliances where the selected appliance becomes a cycle of operation associated with the consumable usage data cycle.

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Auto-configuration of a docked system in a multi-OS environment

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The Z124 patent solves the following problem:

This application relates generally to the field around the mobile computing, and especially to support many user environment through the use of multiple operating systems on a single mobile computing device.

Our analysis of this patent is as follows:

Z124’s patent US 9152582 B2 deals with Auto-configuration of a docked system in a multi-OS environment.
A mobile computing devices with a mobile operating systems and desktop operating systems running simultaneously and independently on a shared grain without virtualization. The mobile operating system provides a user experience for mobile computing devices that case the mobile environment. The desktop operating system provides a complete desktop user experience when the mobile computing device is docked to a secondary terminal around. The mobile computing device configures the mobile operating system and / or desktop operating system to take advantage of a secondary round landed terminal. The mobile computing device may be a smartphone running the Android mobile OS and a complete desktop Linux distribution on a modified Android kernel.

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Determining usefulness of a data alert

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The Domo, Inc. patent solves the following problem:

Our analysis of this patent is as follows:

Domo, Inc.’s patent US 9082282 B1 deals with Determining usefulness of a data alert.
An alert to provide a user notification when a cause that situation regarding the operation of a business that satisfied. Before making the alert, a proposed trigger alert conditions can be received. The trigger conditions can be compared to a database of operational data related to business operations over a period of time to obtain the historical data purposes. The historical data in the vise may indicate how the proposed alert would work if applied to the operational data for the period of time, for example, by showing how the many times the alert may be triggered during the period of the season. The historical data in the vise can be given to a user, and facilitate user determination if the proposed alert will perform as intended. Once the desired proposed alert entered, user can put the proposed alert as a real alert.

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Cross-environment event notification

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The Z124 patent solves the following problem:

This relates generally to the field of mobile environments Computing, and especially to support many user environment through the use of multiple operating systems on a single mobile computing device.

Our analysis of this patent is as follows:

Z124’s patent US 9071625 B2 deals with Cross-environment event notification.
A mobile computing devices with a mobile operating systems and desktop operating systems running simultaneously and independently on a shared grain without virtualization. The mobile operating system provides a user experience for mobile computing devices that case the mobile environment. The desktop operating system provides a complete desktop user experience when the mobile computing device is docked to a second user environment. Cross-around title and event handling allow the user to be informed and to respond to events that occurred in the mobile operating system by about user associated with the desktop operating system. Events that may trigger cross-around title will be local events and / or isolated events. The mobile computing device may be a smartphone running the Android mobile operating system and a complete desktop Linux distribution on a modified Android kernel.

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Under trailer aerodynamic control system

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The R Henderson II Robert patent solves the following problem:

This invention relates to the reduction in aerodynamic drag for the transfer of land vehicles; particularly to an improved method and device for reducing the aerodynamic drag and to improved performance and stability of the vehicle on earth by building on and increasing the mass and velocity of the airflow passing under a car.

Our analysis of this patent is as follows:

R Henderson II Robert’s patent US 9045176 B1 deals with Under trailer aerodynamic control system.
One under the trailer flight control system which increases the air mass, organizations and velocity before mounted again airflow direction panel and a rear airflow modifier mounted on a durable and movable way to the location near the under side of a truck trailer before the trailer wheels and axles to better handle the rush of air around the trailer wheel and axle assembly. In operation, the rear mounted airflow modifier collects the airflow from the front mounted modifiers and routs impinging air to exit through the trailer wheel well past the end of the trailer for the controlled road spray and splash while circling brake and running cold and reduces parasitic drag on the trailer as it moves on highway while reducing driver fatigue through improved handling characteristics.

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