Aminopyrimidines as Syk inhibitors

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The Merck Sharp & Dohme Corp., , Merck Canada Inc. patent solves the following problem:

Spleen Tyrosine Kinase (SYK) is a protein tyrosine kinase described as a key mediator of immunoreceptor signaling a host of inflammatory cells including mast cells, B-cells, macrophages and neutrophils. These immunoreceptors, including Fc receptor and the B-cell receptor, is important for allergic diseases, and antibody-mediated autoimmune diseases and thus pharmacologically interfering SYK conceivably treat these diseases.

Our analysis of this patent is as follows:

Merck Sharp & Dohme Corp., , Merck Canada Inc.’s patent US 8735417 B2 deals with Aminopyrimidines as Syk inhibitors.
The present invention provides new pyrimidine amines of formula (I), which is a strong inhibitor of spleen tyrosine kinase, and is useful in the treatment and prevention of diseases mediated by said enzyme, such as asthma, COPD and rheumatoid arthritis.

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Integrated emergency medical database system

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The Golden Hour Data Systems, Inc. patent solves the following problem:

This invention relates to an integrated system of medical database. More specifically, this invention relates to a medical database for emergency medical transportation industry.

Our analysis of this patent is as follows:

Golden Hour Data Systems, Inc.’s patent US 8712793 B2 deals with Integrated emergency medical database system.
An integrated medical database system for business emergency medical transportation disclosed. The system includes a dispatch module, clinical module, administration module and billing module. Each module to communicate data with one or more other modules to form a system for use in data sharing, thus achieving an end-to-end automation emergency care in medical accounting. Internal consistency checks made by the system to ensure that proper treatments made according to a choice diagnosis.

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Cross-environment redirection

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The Z124 patent solves the following problem:

This relates generally to the field of mobile environments Computing, and especially to support many user environment through the use of multiple operating systems on a single mobile computing device.

Our analysis of this patent is as follows:

Z124’s patent US 8683496 B2 deals with Cross-environment redirection.
Cross-around providing support and companionship user to provide a seamless computing experience in a multi-operating system environment Computing. The multi-operating system computing environments may include a mobile operating system and a desktop operating system running simultaneously and independently on a mobile device Computing. Full user interaction support given for redirected and / or application showed rendered using a long graphics context. A high input queue handles input events from the virtual input devices for remote application shown. Distance showed maps application to another space motion in the input queue. The mobile computing device may be a smartphone running the Android mobile operating system and a complete desktop Linux distribution on a modified Android kernel.

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Lid for closing a cup

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The Constantia Teich Gmbh patent solves the following problem:

The invention relates to a lid for closing a cup along a circumferential sealing rim where the lid comprises at least one aluminum foil and an optionally multilayer polymer coextruded films to aluminum foil and a strong -that line of weakness given the polymer film, equivalent to the introduction of claim 1.

Our analysis of this patent is as follows:

Constantia Teich Gmbh’s patent US 8652644 B2 deals with Lid for closing a cup.
A lid (2) for the end of a cup (1) by a peripheral sealing edge (10) and a method for the production of such a lid. lid includes at least one aluminum film and an optionally multi-layered plastic layer that is co-extruded film to aluminum and has a closed predetermined tear lines (3). The plastic layer made of plastic based on polyethylene (PE) or plastic based on polypropylene (PP), and the predetermined tearing line introduced into the plastic layer preferably with a CO2 laser. The predetermined tear lines (3) can be given directly to the sealing edge region (10).

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Crystalline anhydrate with anticholinergic efficacy

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The Boehringer Ingelhein International Gmbh patent solves the following problem:

Tiotropium bromide is known from European Patent Application EP 418 716 A1 and the following chemical structure:

Our analysis of this patent is as follows:

Boehringer Ingelhein International Gmbh’s patent US 7968717 B2 deals with Crystalline anhydrate with anticholinergic efficacy.
The invention relates to a new crystalline anhydrate of tiotropium bromide, the process of preparing it and use it for the preparation of a pharmaceutical composition for the treatment of respiratory complaints, especially for treatment COPD (chronic obstructive pulmonary disease) and asthma.

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Method and system for executing a task and medium storing a program therefor

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The International Business Machines Corporation patent solves the following problem:

The present invention relates to a method (and system) to accomplish a task and, especially, in a way to accomplish a task (for example, a low latency service) that includes keeping a second project, a garbage collector in a primary role preemptable said second work.

Our analysis of this patent is as follows:

International Business Machines Corporation’s patent US 7756911 B2 deals with Method and system for executing a task and medium storing a program therefor.
A method (and system) to accomplish a task includes keeping a primary role waste collected in a waste of tax, and to carry out a second project, the waste preemptable tax (for example, o'clock) in the second project.

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Radiation crosslinking of halogen-free flame retardant polymer

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The Sabic Innovative Plastics Ip B.V. patent solves the following problem:

Crosslinked polyamide compositions known in the art (See, W. Feng et al., Radiation Physics and Chemistry, 63, pp. 493-496 (2002)). Japanese published application 59-012936A2 describes a crosslinked polyamide resins that obtained by exposing a polyamide resin containing a crosslinker of a radiation beam. resin will be free glass fiber, and a flame retardant or filler can be incorporated into the resin.

Our analysis of this patent is as follows:

Sabic Innovative Plastics Ip B.V.’s patent US 7423080 B2 deals with Radiation crosslinking of halogen-free flame retardant polymer.
Cross-linking, flame retardant polymer composition which containing a polyamide or polyester; a flame retardant system; and a crosslinking agent.

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CD40-related receptor that binds CD40L

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The Incyte Corporation patent solves the following problem:

Signal transduction is the general process that cells respond to extracellular signals. Signal transduction across the plasma membrane began to bind a signal molecule, for example, a hormone, neurotransmitter, or growth factors, into a cell membrane receptor. receptor, thus activated, triggers an intracellular biochemical cascade that ends with the activation of an intracellular target molecule, such as a transcription factors. This process of signal transduction regulates all kinds of cell functions, including cell growth, inequality, and gene transcription.

Our analysis of this patent is as follows:

Incyte Corporation’s patent US 7378492 B2 deals with CD40-related receptor that binds CD40L.
Various embodiments of the invention provide human receptor-associated membrane protein (REMAP) and Q polynucleotides which identify and encode REMAP. Embodiments of the invention also giving expression vector, host cells, antibodies, agonists and antagonists. Some embodiments provide methods for diagnosing, treating, or preventing diseases associated with aberrant expression of REMAP.

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Human protein phosphatase 2C

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The Incyte Corporation patent solves the following problem:

Change protein phosphorylation is ubiquitous methods used to control many of intracellular events in eukaryotic cells. It is estimated that more than ten percent of the active protein in a typical mammal cell are phosphorylated. Kinases to facilitate the transfer of high-energy phosphate group from adenosine triphosphate (ATP) to the target protein hydroxyamino acid residues serine, threonine, or tyrosine. Phosphatases, in contrast, take the phosphate groups. Extracellular signal including the hormone, neurotransmitter, growth and inequality factors may activate kinases, which takes place as the cell surface of cells or as activator in the final effector proteins, as well as other places along the way signal transduction. Cascade of kinases occur, as well as sensitive kinases second messenger molecules. This system allows for equipment to amplify the weak signal (lower abundance of growth factor molecules, for example), as well as the synthesis of many weak signal into an all-or-nothing answer. Phosphatases, then, is necessary to determine the extent of phosphorylation in cells and, with kinases, controlling key cellular processes such as metabolic enzyme activity, proliferation, cell growth and inequality, cell adhesion, and cell cycle progression.

Our analysis of this patent is as follows:

Incyte Corporation’s patent US 7029897 B2 deals with Human protein phosphatase 2C.
invention provides human kinases and phosphatases (KAP) and polnucleotides to recognize and encode KAP. invention also provides expresson vector, host cells, antibodies, agonists and antagonists. invention also provides methods for diagnosing, treating, or preventing diseases associated with aberrant expression of KAP.

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Filler binder for tablets

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The Cooperatie Cosun U.A. patent solves the following problem:

The invention relates to a novel filler-binder for tablets, a process of making tablets using said filler, binder and the tablets obtained in said process.

Our analysis of this patent is as follows:

Cooperatie Cosun U.A.’s patent US 6667055 B2 deals with Filler binder for tablets.
The invention relates to a novel filler-binder for tablets, which showed a significantly reduced lubricant sensitivity when compared by a filler-binder. The invention further relates to a process to make said filler, binder and the tablets obtained in said process.

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