Substituted pyridine spleen tyrosine kinase (SYK) inhibitors

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The Merck Sharp & Dohme Corp., , Merck Canada Inc. patent solves the following problem:

Spleen Tyrosine Kinase (SYK) is a protein tyrosine kinase described as a key mediator of immunoreceptor signaling a host of inflammatory cells including mast cells, B-cells, macrophages and neutrophils. These immunoreceptors, including Fc receptor and the B-cell receptor, is important for allergic diseases, and antibody-mediated autoimmune diseases and thus pharmacologically interfering SYK conceivably treat these diseases.

Our analysis of this patent is as follows:

Merck Sharp & Dohme Corp., , Merck Canada Inc.’s patent US 9376418 B2 deals with Substituted pyridine spleen tyrosine kinase (SYK) inhibitors.
invention provides certain substituted Pyridines of Formula (I) or pharmaceutically acceptable salts thereof, wherein R1, R2, P3, R4, rcy, CY, and t as described here. invention also provides pharmaceutical compositions comprising such compounds, and methods of using the compounds for treating diseases or conditions mediated spleen tyrosine kinase (SYK) kinase.

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Halogen-free, fireproof, transparent thermoplastic compositions having high thermomechanical strength, in particular for encapsulation in photovoltaic modules

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The Arkema France patent solves the following problem:

Our analysis of this patent is as follows:

Arkema France’s patent US 9331215 B2 deals with Halogen-free, fireproof, transparent thermoplastic compositions having high thermomechanical strength, in particular for encapsulation in photovoltaic modules.
A transparent, fireproof thermoplastic composition which is free from halogen compounds and include a polyamide-block graft copolymer formed a polyolefin backbone and, on average, at least one polyamide graft. The grafts attached to the backbone by the radicals of an unsaturated monomer (X) has a function able to react in a polyamide, and the radicals of the unsaturated monomer (X) is attached to the roots the backbone by grafting or co-polymerisation of the double bond. composition includes, as a weight percentage of the total composition: 90 to 99 wt% of polyamide-block graft copolymer, and 1 to 10 wt% of metal salts of phosphoric acid.

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Methods for promoting neuronal development and/or health

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The Mead Johnson Nutrition Company patent solves the following problem:

The brain has only 2% of the total weight of the body, but it is a difficult organ used in 30% of calories in the day and nutrients. (Harris, JJ et al, The Energetics of CNS White Matter jour Neuroscience, January 2012: 32 (1): 356-371). The human brain and nervous system begin construction early in prenatal life and the two continue to develop until the age of three. This early development may have lifelong effects on overall brain and nervous system health. Therefore, brain nutrients become important additives in the diet of infants, children and pregnant and lactating women because of their ability to improve early brain development and the prevention and protection from brain and nervous system injury or illness. Moreover, brain nutrition is important for adults, as many nutrients to the developing nervous system to repair and provide neuroprotective benefits to health.

Our analysis of this patent is as follows:

Mead Johnson Nutrition Company’s patent US 9241923 B2 deals with Methods for promoting neuronal development and/or health.
The present disclosure is directed to methods for improving neuronal health and / or development of a subject by providing nutritional composition comprising a neurologic component, wherein the neurologic component to develop the brain and nervous system development and further provide neurological protection and repair. The neurologic component may include lactoferrin, zinc sulfate, one or more organosulfur compounds, and mixtures thereof.

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Methods for promoting neuronal development and/or health

You’ve invested time, talent, and energy into making a dent in the universe with your invention and ideas. Now it’s time for Utility, Provisional or Design Patent Creation with PowerPatent software and services.

The Mead Johnson Nutrition Company patent solves the following problem:

The brain has only 2% of the total weight of the body, but it is a difficult organ used in 30% of calories in the day and nutrients. (Harris, JJ et al, The Energetics of CNS White Matter jour Neuroscience, January 2012: 32 (1): 356-371). The human brain and nervous system begin construction early in prenatal life and the two continue to develop until the age of three. This early development may have lifelong effects on overall brain and nervous system health. Therefore, brain nutrients become important additives in the diet of infants, children and pregnant and lactating women because of their ability to improve early brain development and the prevention and protection from brain and nervous system injury or illness. Moreover, brain nutrition is important for adults, as many nutrients to the developing nervous system to repair and provide neuroprotective benefits to health.

Our analysis of this patent is as follows:

Mead Johnson Nutrition Company’s patent US 9226914 B2 deals with Methods for promoting neuronal development and/or health.
Expressed the way for the development of neuronal health and / or development of a subject by providing nutritional composition comprising docosahexaenoic acid and alpha-lipoic acid. The nutritional composition may further include lactoferrin, a prebiotic, a probiotic, and mixtures thereof. Further disclosed are methods for the rapid development of neuronal activity and / or strengthen the electrochemical synapse signaling by providing the nutritional composition (s) disclosed in a target subject.

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Cross-environment application compatibility for single mobile computing device

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The Z124 patent solves the following problem:

This relates generally to the field of mobile environments Computing, and especially to support many user environment through the use of multiple operating systems on a single mobile computing device.

Our analysis of this patent is as follows:

Z124’s patent US 9160796 B2 deals with Cross-environment application compatibility for single mobile computing device.
A seamless cross-around workflow given a multi-operating system environment Computing. The multi-operating system computing environments may include a mobile operating system and a desktop operating system running simultaneously and independently on a mobile device Computing. Two or more application programs, running the operating system independent of user interaction with the state information including user data, user settings, and / or application context information. Interaction with the state information may be shared for the applications used primarily to access and edit the user's local content as well as applications that communicate with a remote server or access and navigate other remote content ( for example, Internet-based application, browser, etc.). The mobile computing device may be a smartphone running the Android mobile operating system and a complete desktop Linux distribution on a modified Android kernel.

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Pyridyl aminopyridines as Syk inhibitors

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The Merck Sharp & Dohme Corp. patent solves the following problem:

Spleen Tyrosine Kinase (SYK) is a protein tyrosine kinase described as a key mediator of immunoreceptor signaling a host of inflammatory cells including mast cells, B-cells, macrophages and neutrophils. These immunoreceptors, including Fc receptor and the B-cell receptor, is important for allergic diseases, and antibody-mediated autoimmune diseases and thus pharmacologically interfering SYK conceivably treat these diseases.

Our analysis of this patent is as follows:

Merck Sharp & Dohme Corp.’s patent US 9120785 B2 deals with Pyridyl aminopyridines as Syk inhibitors.
The present invention provides new pyrimidine amines of formula I are potent inhibitor of spleen tyrosine kinase, and is useful in the treatment and prevention of diseases mediated by said enzyme, such as asthma, COPD, rheumatoid arthritis, and cancer .

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Extended graphics context with common compositing

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The Z124 patent solves the following problem:

This relates generally to the field of mobile environments Computing, and especially to support many user environment through the use of multiple operating systems on a single mobile computing device.

Our analysis of this patent is as follows:

Z124’s patent US 9077731 B2 deals with Extended graphics context with common compositing.
Cross-around providing support and companionship user to provide a seamless computing experience in a multi-operating system environment Computing. The multi-operating system computing environments may include a mobile operating system and a desktop operating system running simultaneously and independently on a mobile device Computing. The mobile operating system may be associated with a first user environment and desktop operating systems may be associated with a second user environment. Real-time display of the applications running on the mobile operating system in the second user environment provided by the translation application with a high graphics context of mobile operating systems. Using graphic for many applications translated into about a graphics frame. The mobile computing device may be a smartphone running the Android mobile operating system and a complete desktop Linux distribution on a modified Android kernel.

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Synbiotic mixture

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The Nestec S.A. patent solves the following problem:

The human colon colony in a wide range of bacteria that have both positive and negative effects on gut physiology as well as having other systemic influences. Predominant group of bacteria found in the colon include Bacteroides, bifidobacteria, eubacteria, clostridia and lactobacilli. The bacteria present have fluctuating activities in response to substrate availability, redox potential, pH, O2 tension and distribution in the colon. In general intestinal bacteria can be divided into species that could potentially exert any harmful or beneficial effects on the host. Pathogenic effects (which can cause clostridia or Bacteroides, for example) include diarrhea, infections, liver damage, carcinogenesis and intestinal corruption. Health-promoting effects may be due to inhibition of growth and colonization of harmful bacteria, stimulation of immune functions, improve digestion and absorption of essential nutrients and synthesis of vitamins. An increase in the number and / or activity of bacteria in the genus Bifidobacterium and Lactobacillus that have health promoting properties is desirable.

Our analysis of this patent is as follows:

Nestec S.A.’s patent US 9005682 B2 deals with Synbiotic mixture.
This invention relates to a preparation containing a probiotic bacterial strain and a prebiotic mixture comprising 5-70 wt% of at least one N-acetylated oligosaccharide selected from the group consisting Ga1NAc1,3Ga11,4G1c and Ga11,6Ga1NAc1,3Ga11,4G1c, 20- 95 wt% of at least one neutral oligosaccharide selected from the group consisting Ga11,6Ga1, Ga11,6Ga11,4G1c Ga11,6Ga11,6G1c, Ga11,3Ga11,3G1c, Ga11 3Ga11,4G1c, Ga1 1,6Ga1 1,6Ga1 1, 4GIc, Ga1 1,6Ga1 1,3Ga1 1,4GIc Ga1 1,3Ga1 1,6Ga1 1,4GIc and Ga11,3Ga11,3Ga11,4G1c and 2-50 wt% at least one sialylated oligosaccharide selected from the group consisting NeuAc2,3Ga11, 4G1c and NeuAc2,6Ga11,4G1c. The invention is given to food products comprising said preparation and use in preparation for the prevention and treatment of infections.

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Crash sensor systems utilizing vehicular inertial properties

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The Automotive Technologies International, Inc. patent solves the following problem:

Our analysis of this patent is as follows:

Automotive Technologies International, Inc.’s patent US 8914196 B1 deals with Crash sensor systems utilizing vehicular inertial properties.
Electronic crash sensor system for a vehicle including at least one inertial measurement device arranged in the vehicle to measure the inertial properties of the car, a processor that includes or works in a crash sensing algorithm that determines the vehicle detect a crash based on the inertial properties measured in each inertial measurement device and a positioning system arranged in the vehicle position to provide it. The inertial properties measured by each inertial measurement device modified base position and then given to the crash sensing algorithm so that the crash sensing algorithm determines if the vehicle detect a crash based on modified inertial properties measured by each inertial measurement device. Self-testing device in every inertial measurement is made.

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Low-caloric high-protein nutritional composition for the stimulation of muscle protein synthesis

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The N.V. Nutricia patent solves the following problem:

Age-related volunteers loss of muscle mass and strength occurs during the ages and is called sarcopenia [1]. As the degenerative loss of skeletal muscle mass, it occurs at a rate of 3-8% per decade after the age of 30 years, and accelerate from 60 years of age. The two impaired muscle mass and muscle strength associated with age-related loss of muscle function.

Our analysis of this patent is as follows:

N.V. Nutricia’s patent US 8846759 B2 deals with Low-caloric high-protein nutritional composition for the stimulation of muscle protein synthesis.
The present invention relates to the use of a low-caloric high-protein nutritional composition for use in the prevention or treatment of a disease or condition in a mammal, including muscle decline, as well as specific low-caloric high-protein nutritional composition for stimulating muscle protein synthesis in a mammal. In particular, the invention relates to the use of a nutritional composition comprising per 100 kcal: (i) at least 12 g of proteinaceous matter comprising at least about 80 weight% of whey protein, relative to total proteinaceous matter, and containing at least 11 weight% of leucine, relative to the total proteinaceous matter, at least 20 weight% in a free form, relative to the total leucine, ( ii) a source of fat and a source of digestible carbohydrates, for the prevention or treatment of a disease or condition involving reduced muscle in a mammal, especially in an old mammal, which nutritional composition administered as 1 to 2 servings daily, each serving consisting of between 80 and 200 kcal.

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