Pyrazolyl derivatives as Syk inhibitors

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The Merck Sharp & Dohme Corp., , Merck Canada Inc. patent solves the following problem:

Spleen Tyrosine Kinase (SYK) is a protein tyrosine kinase described as a key mediator of immunoreceptor signaling a host of inflammatory cells including mast cells, B-cells, macrophages and neutrophils. These immunoreceptors, including Fc receptor and the B-cell receptor, is important for allergic diseases, and antibody-mediated autoimmune diseases and thus pharmacologically interfering SYK conceivably treat these diseases.

Our analysis of this patent is as follows:

Merck Sharp & Dohme Corp., , Merck Canada Inc.’s patent US 9242984 B2 deals with Pyrazolyl derivatives as Syk inhibitors.
The present invention provides new pyrazole derivatives of formula I are potent inhibitor of spleen tyrosine kinase, and is useful in the treatment and prevention of diseases mediated by said enzyme, such as asthma, COPD, rheumatoid arthritis, and cancer .

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Process for the production of ultrapure galacto-oligosaccharides

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The Ritter Pharmaceuticals, Inc. patent solves the following problem:

Our analysis of this patent is as follows:

Ritter Pharmaceuticals, Inc.’s patent US 9200303 B2 deals with Process for the production of ultrapure galacto-oligosaccharides.
The present invention describes a process for preparing pure (95%) galacto-oligosaccharides (gos), starting from the forced low purities by the use of continuous microbiological preparations involving Saccharomyces cerevisiae and streptococcus thermophilics.

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Thermoplastic and/or elastomeric composite based on carbon nanotubes and graphenes

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The Arkema France patent solves the following problem:

Carbon nanotubes (CNTs) possess particular crystalline structures, of tubular and hollow forms, formed rolling in one or more individual graphite sheets. In the case of nanotubes comprising several roiled plates or walls, the rolling-up operation is coaxial along a longitudinal direction. A distinction is made between single-walled nanotubes (SWNTs) and multiwalled nanotubes (MWNTs).

Our analysis of this patent is as follows:

Arkema France’s patent US 8808580 B2 deals with Thermoplastic and/or elastomeric composite based on carbon nanotubes and graphenes.
The present invention relates to a composite of carbon nanotubes and graphenes agglomerated solid form comprising: a) carbon nanotubes, in representing from 0.1% to 50% weight, preferably from 10% to 40% by weight relative to the total weight of the composite; b) graphenes, in representing from 0.1% to 20% in weight, preferably from 1% to 10% in weight relative to the total weight of the composite; and c) a polymer composition comprising at least one thermoplastic polymer and / or an elastomer. The present invention also relates to a process for preparing said composite, use it to make a composite product, and also to the various applications of composite products.

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Integrated emergency medical database system

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The Golden Hour Data Systems, Inc. patent solves the following problem:

This invention relates to an integrated system of medical database. More specifically, this invention relates to a medical database for emergency medical transportation industry.

Our analysis of this patent is as follows:

Golden Hour Data Systems, Inc.’s patent US 8712793 B2 deals with Integrated emergency medical database system.
An integrated medical database system for business emergency medical transportation disclosed. The system includes a dispatch module, clinical module, administration module and billing module. Each module to communicate data with one or more other modules to form a system for use in data sharing, thus achieving an end-to-end automation emergency care in medical accounting. Internal consistency checks made by the system to ensure that proper treatments made according to a choice diagnosis.

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Compounds

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The Glaxo Group Limited patent solves the following problem:

Chemokines are believed to play an important role in immune and inflammatory responses in a number of diseases or conditions of the CC-chemokine receptor 4 (CCR4) original clone from a basophilic cell line (Power et al, J. Biol. Chem.; 270: 19495: 1995). The small molecule CCR4 receptor antagonists known in the art, with examples that described in Andrews et al (mol Pharmacol 73 :. 855, 2008).

Our analysis of this patent is as follows:

Glaxo Group Limited’s patent US 8507543 B2 deals with Compounds.
Indazole compounds, processes for their preparation, intermediates used in these processes, pharmaceutical compositions containing such compounds and their use in therapy.

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Positive temperature coefficient materials with reduced negative temperature coefficient effect

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The Sabic Innovative Plastics Ip B.V. patent solves the following problem:

It is known that polymers can be electrical conductive by dispersing therein suitable amount of conductive particulate fillers such as carbon black or fine metal particles. Over recent years, with particular interest in the compositions that show positive temperature coefficient (PTC) behavior, ie, which showed a very strong increase in the surface resistivity of a particular temperature range.

Our analysis of this patent is as follows:

Sabic Innovative Plastics Ip B.V.’s patent US 8496854 B2 deals with Positive temperature coefficient materials with reduced negative temperature coefficient effect.
Positive temperature coefficient (PTC) composition having a reduced negative temperature coefficient effect (NTC) given achieved without crosslinking the thermoplastic base material. The PTC composition includes a thermoplastic base resin, an electrically conductive filler particles in a polymeric additive dispersed PTC composition.

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Method for producing an aqueous solution hydroxylamine

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The Domo Caproleuna Gmbh patent solves the following problem:

Special safety conditions must comply with the publication of HA as heat weakness is one of its assets, ie it decomposes in a bone, especially in the presence of metal ion, the strongly alkaline media, and high temperature and concentration. The heat composition of HA causes irreversible losses and reduces product yield.

Our analysis of this patent is as follows:

Domo Caproleuna Gmbh’s patent US 7425247 B2 deals with Method for producing an aqueous solution hydroxylamine.
This invention relates to a method for the production of an aqueous solution of free hydroxylamine (HA) simultaneous countercurrent treatment of a HA salt with ammonia or ammonia water, then divide the HA by distillation and reconcentrating the aqueous HA solution in a countercurrent with a stripping medium. The stripping medium used according to the invention is a mixture of steam and a non-condensable inert gas and the process temperature to a defined pressure to control the number of non-condensable inert gas inlet column. The non-condensable inert gas is nitrogen. This results in increased safety and a reduced loss in the procedures for bringing the aqueous solution of free HA.

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Mammalian imidazoline receptor

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The Incyte Genomics, Inc. patent solves the following problem:

Phylogenetic relationships among organisms shown many times, and studies from a diversity of prokaryotic and eukaryotic organisms suggest a more or less gradual evolution in biochemical and physiological mechanisms and metabolic pathways . Despite the different evolutionary pressures, the proteins that control the cell cycle in yeast, nematode, flies, mice, and humans have common chemical and structural parts and modulate the same general movement. Comparing human gene sequences from other organisms which structure and / or function known allow researchers to draw analogies, and developing model systems for testing diagnostic and therapeutic agents for the human condition, diseases, and disorders.

Our analysis of this patent is as follows:

Incyte Genomics, Inc.’s patent US 6475752 B1 deals with Mammalian imidazoline receptor.
The present invention is a mammal nucleic acid molecules and fragments thereof. It also provides for the use of mammal nucleic acid molecules for the characterization, diagnosis, evaluation, treatment, or prevention of conditions, diseases and disorders associated with the expression and production for a model system. the invention further provides expression vector and host cells for production of proteins encoded in the mammalian nucleic acid molecule. the invention further provides a mammal proteins or portions thereof. the invention further provides for the use of nucleic acid molecules and proteins in assays to detect or purify ligands.

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Sound field controller and control method

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The Matsushita Electric Industrial Co., Ltd. patent solves the following problem:

The present invention relates to a sound field controller for use in audio-visual (AV) equipment, and a method used in such a sound field controller. Particularly, the present invention relates to a sound field controller for sound reproduction with a greeting in front by controlling the distance on the view and the feeling of expansion of a sound image , and with more natural reproduction frequency.

Our analysis of this patent is as follows:

Matsushita Electric Industrial Co., Ltd.’s patent US 5742688 A deals with Sound field controller and control method.
A sound field controller of the invention reproduces a sound field that gives a distance perspective depending on a position of a sound image for an audience. The sound field controller includes: an A / D converter; a signal processing section for processing the digital signal using the predetermined parameters, and to generate a voice signal; an input device for inputting conditions including a position in a voice of local and some distance from a listener; a standard controller to make arguments in the section signal processing so that the voice signal with attributes according to the input conditions; a D / A converter; and a reproducing unit for expanding and copying the signal output from the D / A converter.

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Medical information card

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The Micro Innovations, Incorporated patent solves the following problem:

It is desirable that when individuals carry with them important medical information that may be useful in times of medical emergency when medical treatment is necessary and the time of definition. Various attempts have been made to provide medical information cards. Often, however, these trials is not practical in that they require special equipment to read or included microfilm or microchip.

Our analysis of this patent is as follows:

Micro Innovations, Incorporated’s patent US 5171039 A deals with Medical information card.
A wallet size laminated medical information card made by providing information on a variety of centers in a doctor's. The information is then transmitted to a data base in which it is reproduced format software that adjusts the volume of information to wallet size. information will be laser printed on a card that is plastic laminated and folded so that it is in the conventional size credit card, while the information on it read out using special optical devices.

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