Isolation and use of solid tumor stem cells

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The Regents Of The University Of Michigan patent solves the following problem:

Cancer remains the number two cause of death in this country, resulting in more than 500,000 deaths each year. Despite progress in detection and treatment, cancer mortality remains high. Despite remarkable progress in understanding the molecular basis of cancer, this knowledge has not yet translated into effective therapeutic strategies.

Our analysis of this patent is as follows:

Regents Of The University Of Michigan’s patent US 7115360 B2 deals with Isolation and use of solid tumor stem cells.
A small percentage of cells in a firm with strong tumor properties of stem cells. These strong tumor stem cells give rise to two more tumor stem cells and the majority of tumor cells that have lost the capacity for growth and the ability to give rise to new tumors. Therefore, strong tumor heterogeneity appeared before the tumor cell line arising from a strong tumor stem cells.

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Human protein phosphatase 2C

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The Incyte Corporation patent solves the following problem:

Change protein phosphorylation is ubiquitous methods used to control many of intracellular events in eukaryotic cells. It is estimated that more than ten percent of the active protein in a typical mammal cell are phosphorylated. Kinases to facilitate the transfer of high-energy phosphate group from adenosine triphosphate (ATP) to the target protein hydroxyamino acid residues serine, threonine, or tyrosine. Phosphatases, in contrast, take the phosphate groups. Extracellular signal including the hormone, neurotransmitter, growth and inequality factors may activate kinases, which takes place as the cell surface of cells or as activator in the final effector proteins, as well as other places along the way signal transduction. Cascade of kinases occur, as well as sensitive kinases second messenger molecules. This system allows for equipment to amplify the weak signal (lower abundance of growth factor molecules, for example), as well as the synthesis of many weak signal into an all-or-nothing answer. Phosphatases, then, is necessary to determine the extent of phosphorylation in cells and, with kinases, controlling key cellular processes such as metabolic enzyme activity, proliferation, cell growth and inequality, cell adhesion, and cell cycle progression.

Our analysis of this patent is as follows:

Incyte Corporation’s patent US 7029897 B2 deals with Human protein phosphatase 2C.
invention provides human kinases and phosphatases (KAP) and polnucleotides to recognize and encode KAP. invention also provides expresson vector, host cells, antibodies, agonists and antagonists. invention also provides methods for diagnosing, treating, or preventing diseases associated with aberrant expression of KAP.

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Graphical user interface for display and analysis of biological sequence data

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The Eragen Biosciences, Inc. patent solves the following problem:

The present invention relates to a research tool in the computer to find and display biological data. More particularly, the invention relates to a device for computer research using a novel graphical user interface (GUI) to perform computerized research in biological information from various databases and give enhanced graphical representation of biological data, progressive querying, and cross-navigation relationship data.

Our analysis of this patent is as follows:

Eragen Biosciences, Inc.’s patent US 6941317 B1 deals with Graphical user interface for display and analysis of biological sequence data.
A computer research tools provided for searching and displaying biological data. In particular, the invention provides a computer research tools for the manufacture of computerized research of biological information from various databases and provide a novel graphical user interface that significantly enhances biological data representation, progressive querying and cross-navigation in windows and database. invention can be implemented in numerous ways, including as a system, a device, a method, or a computer readable medium.

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Proteases

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The Incyte Corporation patent solves the following problem:

Proteases cleave proteins and peptides in the peptide bond which forms the backbone of the protein or peptide chain. Proteolysis is one of the most important and often enzymatic reactions that occur both inside and outside the cells. Proteolysis is responsible for the activation and maturation of growing polypeptides, the degradation of misfolded and damaged proteins, and the controlled turnover of the peptide within the cell. Proteases involved in digestion, endocrine function, and tissue remodeling during embryonic development, wound healing and normal growth. Proteases play a role in the regulatory process by affecting half the life of the regulatory protein. Proteases involved in the etiology or progression of diseases such as inflammation, angiogenesis, tumor scattering and metastasis, cardiovascular disease, neurological disease, and the bacteria, parasitic, and viral infections.

Our analysis of this patent is as follows:

Incyte Corporation’s patent US 6927056 B2 deals with Proteases.
invention provides in one cysteine ​​proteases and polynucleotides that encode proteases. invention also provides expression vector, host cells, antibodies, agonists and antagonists, as well as methods for diagnosing, treating, or preventing diseases associated with aberrant expression of cysteine ​​proteases.

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Identification card method and apparatus

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The Graphic Laminating Inc. patent solves the following problem:

The use of small plastic identification cards become more common. Bank or department store credit cards are often used instead of cash or checks to make retail purchases and bank cards used to make various banking transactions in automatic tellers. driver's license, identification cards, employee identification, industrial process control, and member cards other uses for these plastic cards.

Our analysis of this patent is as follows:

Graphic Laminating Inc.’s patent US 4589687 A deals with Identification card method and apparatus.
A tamper proof identification card. The express card made from a core role in salvation sandwiched between two upper and lower layers of polyester coated with polyethylene. The security role boundaries in his periphery a polyester border similar to the upper and lower layers. The layered card heat and pressure treated to encapsulate the paper. Should the seal that is not enough, any attempt to change the information marked on security paper that is readily apparent.

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