Processes for making lactose utilizing pre-classification techniques and pharmaceutical formulations formed therefrom

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The Dmv-Fonterra Excipients Technology Gmbh, , Glaxo Group Limited patent solves the following problem:

In the field of inhalation therapy, it is generally desirable to use therapeutic molecules having a particle size (ie, diameter) in the range of 1 to 10 m. carrier molecule or excipients, such as lactose, canine therapeutic preparation also includes significantly larger diameter particles (for example, 100 to 150 m) which are not normally penetrate into the upper respiratory tract to the same degree as the active ingredient. In general, it is better to use a smaller particle size for the lactose or a lactose blend having a defined ratio of coarse and fine lactose.

Our analysis of this patent is as follows:

Dmv-Fonterra Excipients Technology Gmbh, , Glaxo Group Limited’s patent US 9365905 B2 deals with Processes for making lactose utilizing pre-classification techniques and pharmaceutical formulations formed therefrom.
A process for forming lactose suitable for use in a pharmaceutical formulation comprises providing a plurality of lactose particles containing no more than 10% w / w of lactose particles with a number average the particle size of about 70 microns or less; stands the plurality of lactose particles to yield a plurality of milled lactose particles with an average particle size, (D50), from 50 micron to 100 micron; and classifying the plurality of milled lactose particles at least two pieces consisting of a fine particle and a coarse particle in which the fine particle has an average particle size, (D50), from 3 microns to 50 microns, and the coarse particle has an average particle size, (D50), from 40 micron to 250 micron.

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High energy liquid enteral nutritional composition

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The N.V. Nutricia patent solves the following problem:

The present invention relates in general to a liquid enteral composition for providing nutrition, or as a supplement, or as a complete nutrition, with a high energy inside.

Our analysis of this patent is as follows:

N.V. Nutricia’s patent US 9345256 B2 deals with High energy liquid enteral nutritional composition.
High energy and high protein liquid nutrition enteral composition which includes micellar casein and caseinate, a optionally a small amount of whey.

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Dry powder pharmaceutical composition for inhalation

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The Daiichi Sankyo Company, Limited patent solves the following problem:

Japanese Patent No. 3209946 (Patent Document 1) discloses compounds with neuraminidase inhibitory activity, including the compound represented by formula (I) shown below. The compound represented by formula (I) have excellent neuraminidase inhibitory activity and is expected to be useful as a drug for treating and preventing influenza virus infection. Japanese Patent No. 4205314 (Patent Document 2) revealed a concentration of the compound represented by formula (I) can remain on for a long time in the respiratory tissues like lung (Patent Document 2).

Our analysis of this patent is as follows:

Daiichi Sankyo Company, Limited’s patent US 9339487 B2 deals with Dry powder pharmaceutical composition for inhalation.
There was a dry powder pharmaceutical composition for inhalation is useful for preventing and / or treating influenza virus infections included as a medicinal component of a compound represented by formula (I): and optionally a compound represented by formula (II): a pharmacologically acceptable salt thereof, or a hydrate thereof.

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Trailer sail

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The Vanguard National Trailer Corporation patent solves the following problem:

Fairings used to improve the aerodynamics of a vehicle and are often added to the outside of a car to reduce drag while in motion. Fairings can be added to many places in the tractor and trailers to promote the launch of these great vehicles. In the past, the fairings included front and rear of the tractor as before, on, under, and behind the trailers. Fairings also placed in front of and behind the wheels of a trailer to improve aerodynamics.

Our analysis of this patent is as follows:

Vanguard National Trailer Corporation’s patent US 9296433 B2 deals with Trailer sail.
A flexible trailer fairing for reducing aerodynamic drag in a trailer on the road revealed. A fourfold flexible fairing system can be used to reduce the drag from the trailer's landing gear and wheel assembly. Many systems in keeping with the flexible fairing teaching while continuing to use also disclosed.

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Aminopyrimidines as Syk inhibitors

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The Merck Sharp & Dohme Corp. patent solves the following problem:

Spleen Tyrosine Kinase (SYK) is a protein tyrosine kinase described as a key mediator of immunoreceptor signaling a host of inflammatory cells including mast cells, B-cells, macrophages and neutrophils. These immunoreceptors, including Fc receptor and the B-cell receptor, is important for allergic diseases, and antibody-mediated autoimmune diseases and thus, pharmacologically interfering with SYK conceivably treat these diseases.

Our analysis of this patent is as follows:

Merck Sharp & Dohme Corp.’s patent US 9290490 B2 deals with Aminopyrimidines as Syk inhibitors.
The present invention provides new pyrimidine amines of formula I are potent inhibitor of spleen tyrosine kinase, and is useful in the treatment and prevention of diseases mediated by said enzyme, such as asthma, COPD, rheumatoid arthritis and cancer.

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2-Pyridyl carboxamide-containing spleen tyrosine kinase (SYK) inhibitors

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The Merck Sharp & Dohme Corp. patent solves the following problem:

Spleen Tyrosine Kinase (SYK) is a protein tyrosine kinase described as a key mediator of immunoreceptor signaling a host of inflammatory cells including mast cells, B-cells, macrophages and neutrophils. These immunoreceptors, including Fc receptor and the B-cell receptor, is important for allergic diseases, and antibody-mediated autoimmune diseases and thus pharmacologically interfering SYK conceivably treat these diseases.

Our analysis of this patent is as follows:

Merck Sharp & Dohme Corp.’s patent US 9216173 B2 deals with 2-Pyridyl carboxamide-containing spleen tyrosine kinase (SYK) inhibitors.
invention provides certain 2-pyridyl formamide-containing compounds of Formula (I) or pharmaceutically acceptable salts thereof, wherein A and B as described here. invention also provides pharmaceutical compositions comprising such compounds, and methods of using the compounds for treating diseases or conditions mediated spleen tyrosine kinase (SYK) kinase.

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Automatic web service monitoring

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The Domo, Inc. patent solves the following problem:

Our analysis of this patent is as follows:

Domo, Inc.’s patent US 9191285 B1 deals with Automatic web service monitoring.
According to various embodiments, the present invention provides a live site performance monitoring in the context of reasonable resource hierarchies found in cloud computing systems. In particular, in an image, the system of the present invention facilitates monitoring of new services Computing without necessarily requires clear knowledge of these new services. Such services may include, for example and without limitation, given the use of an image that State Transfer (REST) ​​architecture, although the techniques described herein may also be used in other architectures. In one embodiment, the system of the present invention works by automatically creating groups of things for performance monitoring, based on the hierarchy of a type. Heuristics can be used to determine aggregatable hierarchy nodes.

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Bipyridylaminopyridines as Syk inhibitors

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The Merck Sharp & Dohme Corp., , Merck Canada Inc. patent solves the following problem:

Spleen Tyrosine Kinase (SYK) is a protein tyrosine kinase described as a key mediator of immunoreceptor signaling a host of inflammatory cells including mast cells, B-cells, macrophages and neutrophils. These immunoreceptors, including Fc receptor and the B-cell receptor, is important for allergic diseases, and antibody-mediated autoimmune diseases and thus pharmacologically interfering SYK conceivably treat these diseases.

Our analysis of this patent is as follows:

Merck Sharp & Dohme Corp., , Merck Canada Inc.’s patent US 9145391 B2 deals with Bipyridylaminopyridines as Syk inhibitors.
The present invention provides new pyrimidine amines of formula I are potent inhibitor of spleen tyrosine kinase, or prodrugs thereof, and useful in the treatment and prevention of diseases mediated by said enzyme, such as asthma, COPD and rheumatoid arthritis and cancer.

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Dual display pinyin touch input

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The Z124 patent solves the following problem:

A substantial number of handheld devices Computing, such as cellular phones, tablets, and E-Readers, make use of a touch screen display will not only save the display information to the user, but also to take inputs from the user's command interface. While touch screen display can increase the configurability of the handheld device and to provide a wide variety of user interface options, this flexibility often comes at a price. The two use the touch screen to provide for and receive user commands, while flexible for the user, in order to obfuscate the display, and cause visual clutter, thus leading to user frustration and loss of yield.

Our analysis of this patent is as follows:

Z124’s patent US 9128660 B2 deals with Dual display pinyin touch input.
These methods and devices including providing a device having at least a first screen and a secondary screen; receiving a first input, where the first input comprising a Pinyin input on the first screen; processing the first input to estimate a character based on previous input; to display the estimated character (s); and to exercise a choice, where the selection includes a choice of traits selected from the estimated character (s).

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Cross-environment communication framework

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The Z124 patent solves the following problem:

This relates generally to the field of mobile environments Computing, and especially to support many user environment through the use of multiple operating systems on a single mobile computing device.

Our analysis of this patent is as follows:

Z124’s patent US 9098437 B2 deals with Cross-environment communication framework.
A mobile computing devices with a mobile operating systems and desktop operating systems running simultaneously and independently on a shared grain without virtualization. The mobile operating system provides a user experience for mobile computing devices that case the mobile environment. The desktop operating system provides a complete desktop user experience when the mobile computing device is docked to a secondary terminal around. Applications in desktop operating systems to communicate with applications and services in the mobile operating system with a framework cross-communication environment. The cross-premises communication structure may include interfaces to the remotable object to allow the process of mobile operating systems and processes in desktop operating systems to share the memory of a thread-safe manner. The mobile computing device may be a smartphone running the Android mobile operating system and a complete desktop Linux distribution on a modified Android kernel.

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