Nutrition with non-viable Bifidobacterium and non-digestible oligosaccharide

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The N.V. Nutricia patent solves the following problem:

A human child is fed human milk develop after birth in an intestinal microbiota rich in lactic acid bacteria. This is due to the presence of non-digestible saccharides on human milk specifically fermented with lactic acid bacteria, particularly bifidobacteria.

Our analysis of this patent is as follows:

N.V. Nutricia’s patent US 9456629 B2 deals with Nutrition with non-viable Bifidobacterium and non-digestible oligosaccharide.
A child and / or child nutrition containing non-viable Bifidobacterium breve and a non-digestible oligosaccharide and its use revealed.

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Substituted diazine and triazine spleen tyrosine kinease (Syk) inhibitors

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The Merck Sharp & Dohme Corp. patent solves the following problem:

Spleen Tyrosine Kinase (SYK) is a protein tyrosine kinase described as a key mediator of immunoreceptor signaling a host of inflammatory cells including mast cells, B-cells, macrophages and neutrophils. These immunoreceptors, including Fc receptor and the B-cell receptor, is important for allergic diseases, and antibody-mediated autoimmune diseases and thus pharmacologically interfering SYK conceivably treat these diseases.

Our analysis of this patent is as follows:

Merck Sharp & Dohme Corp.’s patent US 9416111 B2 deals with Substituted diazine and triazine spleen tyrosine kinease (Syk) inhibitors.
invention provides certain substituted diazine and triazine compounds of Formula (I) (I) or pharmaceutically acceptable salts thereof, wherein R1, R2, P3, R4, rcy, CY, and t as described here. invention also provides pharmaceutical compositions comprising such compounds, and methods of using the compounds for treating diseases or conditions mediated spleen tyrosine kinase (SYK) kinase.

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Adjustable side under-ride guard for sliding axle trailer

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The Stephen Allen Batzer, , Patrick Keith Rogers patent solves the following problem:

The recognized hazard of side collision against dragged trailers traced at least back in 1938 that Robinson invented a peripheral guard for a hook-mounted trailer. See US Pat. No. 2,002,832. In his patent teaches a fixed whole periphery kept for a towed trailer with fixed rear axle. This non-regulated system to guard against the impact on the trailer from all directions.

Our analysis of this patent is as follows:

Stephen Allen Batzer, , Patrick Keith Rogers’s patent US 9352714 B2 deals with Adjustable side under-ride guard for sliding axle trailer.
A side under-ride collision guard described configured sitting in a large trailer equipped with a sliding rear axle, consisting of one or more energy absorbing structures cut wood axially adjustable for the position included in a multiplicity of similar barriers to diminish the impact hazard to other users paths presented lower axial edge (s) in the cargo compartment of the region (s) among the back the wheels of the trailer and the trailer back under-ride guard and / or between a stationary side under-ride guard and publicly trailer's wheels.

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Aerodynamic drag reducing apparatus

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The Stemco Lp patent solves the following problem:

It is known that a significant amount of aerodynamic drag created when a car traveling at velocities typical in a modern way. This is due, in large part, to areas of low pressure prompting the back of the car. The lower the pressure becomes more pronounced as airflow over the vehicle separates from the surfaces vehicles. The event airflow separation also well known in aircraft wing design and, in this case, cause the wing stop.

Our analysis of this patent is as follows:

Stemco Lp’s patent US 9346496 B2 deals with Aerodynamic drag reducing apparatus.
A flight drag reducing apparatus for use in vehicles with lower surfaces that are not streamlined. facilities include folding panels that extend rearward for use in a drag reducing configuration and crushed for use in a space saving configuration.

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Trailer sail

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The Vanguard National Trailer Corporation patent solves the following problem:

Fairings used to improve the aerodynamics of a vehicle and are often added to the outside of a car to reduce drag while in motion. Fairings can be added to many places in the tractor and trailers to promote the launch of these great vehicles. In the past, the fairings included front and rear of the tractor as before, on, under, and behind the trailers. Fairings also placed in front of and behind the wheels of a trailer to improve aerodynamics.

Our analysis of this patent is as follows:

Vanguard National Trailer Corporation’s patent US 9296433 B2 deals with Trailer sail.
A flexible trailer fairing for reducing aerodynamic drag in a trailer on the road revealed. A fourfold flexible fairing system can be used to reduce the drag from the trailer's landing gear and wheel assembly. Many systems in keeping with the flexible fairing teaching while continuing to use also disclosed.

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Chemoenzymatic synthesis of heparin and heparan sulfate analogs

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The The Regents Of The University Of California patent solves the following problem:

Our analysis of this patent is as follows:

The Regents Of The University Of California’s patent US 9290530 B2 deals with Chemoenzymatic synthesis of heparin and heparan sulfate analogs.
The present invention provides a one-pot multi-enzyme method for preparing the UDP-sugars from simple sugar starting materials. invention also provides a one-pot multi-enzyme process for the preparation of oligosaccharides from simple sugar starting materials.

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Devices and methods for reducing vehicle drag

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The Smarttruck Systems, Llc patent solves the following problem:

An ongoing effort to reduce the drag in vehicular structures is of great importance as the fuel economy will be a greater consideration in vehicular design. As the drag of a car increases, the amount of fuel needed to move vehicles also increased because of greater energy required to overcome drag. For example, it states that for a vehicle traveling at 70 mph, 65% of the total fuel consumption of the engine of the car used to overcome drag. Therefore, even a small reduction in drag experienced by a vehicle traveling at a speed of course would result in a significant improvement in fuel economy.

Our analysis of this patent is as follows:

Smarttruck Systems, Llc’s patent US 9056636 B2 deals with Devices and methods for reducing vehicle drag.
In some embodiments of the present invention, a vehicle trailer is described which includes a shelf component that extends from the side wall of the trailer and that describes a sloped surface.

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Truck fairing

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The Volvo Group North America, Llc patent solves the following problem:

From increasing fuel costs continue to encourage strict and semi-trailer tractors designers to search for additional, novel ways to improve vehicle fuel economy. Negative effects of airflow during the trip is always a place to focus, and manufacturers reduce aerodynamic drag, for example, again out forms to avoid the restraint force working directly any moving body Airstream encounter. Fairings, things, foil, covered with hoods, rolled under the bumpers, recessed door handles add to the cost of design and weight, and complicate car repair and servicing. Nevertheless, the designers' goal was to offset these negative effects to a general decrease in drag coefficient as car fuel economy may increase.

Our analysis of this patent is as follows:

Volvo Group North America, Llc’s patent US 9027686 B2 deals with Truck fairing.
A truck includes a frame, an operator cab frame, and a drive axle with a differential. differential can be connected to a drive shaft. A fairing for directing the air flow around the differential is attached to the frame before the drive axle and the front differential. fairing may have a non-deflected position and a deflected position.

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Pea protein peptides with anti Helicobacter pylori activity

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The N.V. Nutricia patent solves the following problem:

Abdominal infections are a major problem for many people, and especially children and patients with an impaired immune system or abdominal pain. The result of the disease can be fatal. Stomach infection often caused by Escherichia coli, Salmonella, Campylobacter, Porphyromonas gingivalis, Clostridium, Enterobacter and Helicobacter, such as Helicobacter pylori.

Our analysis of this patent is as follows:

N.V. Nutricia’s patent US 8999924 B2 deals with Pea protein peptides with anti Helicobacter pylori activity.
The invention relates to a composition comprising pea protein hydrolyzate for the treatment and / or prevention of infection in the stomach pathogens, in particular Helicobacter pylori and / or a disease associated with infection of the stomach pathogen in said mammal.

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Compounds

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The Glaxo Group Limited patent solves the following problem:

Syk is a non-receptor tyrosine kinase involved in coupling activated immunoreceptors signal consuming events that mediate diverse cellular responses, including proliferation, distinction, and phagocytosis. Syk is widely expressed in hematopoietic cells. Syk inhibitor with potential anti-inflammatory and immunomodulating activities. They inhibit SYK-mediated IgG Fc epsilon and gamma receptor and BCR receptor signaling, resulting in inhibition of activation of mast cells, macrophages, and B-cells and relevant inflammatory responses and tissue damage. Mast cells play a major role in type I hypersensitivity reactions associated with urticaria, bronchial asthma, anaphylaxis and other allergic conditions. Therefore, SYK inhibitor has attracted interest from a number of therapeutic areas, including the treatment of rheumatoid arthritis, B-cell lymphoma, asthma, rhinitis and cutaneous disorders such as acute and chronic urticaria, mastocytosis, cutaneous lupus , atopic dermatitis, autoimmune bullous conditions including Pemphigus and pemphigoid and other mast cell mediated skin disease.

Our analysis of this patent is as follows:

Glaxo Group Limited’s patent US 8993560 B2 deals with Compounds.
A compound of formula (I): or a salt thereof; which is an inhibitor of spleen tyrosine kinase (SYK) and therefore potential use in the treatment of diseases resulting from inappropriate activation of mast cells, macrophages, and B-cells and related inflammatory responses and tissue damage, for example inflammatory diseases and / or allergic conditions, in cancer therapy, especially heme malignancies, and autoimmune conditions.

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