Compounds

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The Glaxo Group Limited patent solves the following problem:

Syk is a non-receptor tyrosine kinase involved in coupling activated immunoreceptors signal consuming events that mediate diverse cellular responses, including proliferation, distinction, and phagocytosis. Syk is widely expressed in hematopoietic cells. Syk inhibitor with potential anti-inflammatory and immunomodulating activities. They inhibit SYK-mediated IgG Fc epsilon and gamma receptor and BCR receptor signaling, resulting in inhibition of activation of mast cells, macrophages, and B-cells and relevant inflammatory responses and tissue damage. Mast cells play a major role in type I hypersensitivity reactions associated with urticaria, bronchial asthma, anaphylaxis and other allergic conditions. Therefore, SYK inhibitor has attracted interest from a number of therapeutic areas, including the treatment of rheumatoid arthritis, B-cell lymphoma, asthma, rhinitis and cutaneous disorders such as acute and chronic urticaria, mastocytosis, cutaneous lupus , atopic dermatitis, autoimmune bullous conditions including Pemphigus and pemphigoid and other mast cell mediated skin disease.

Our analysis of this patent is as follows:

Glaxo Group Limited’s patent US 9447074 B2 deals with Compounds.
A compound of formula (I): or a salt thereof; which is an inhibitor of spleen tyrosine kinase (SYK) and therefore potential use in the treatment of diseases resulting from inappropriate activation of mast cells, macrophages, and B-cells and related inflammatory responses and tissue damage, for example inflammatory diseases and / or allergic conditions, in cancer therapy, especially heme malignancies, and autoimmune conditions.

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Dry powder pharmaceutical composition for inhalation

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The Daiichi Sankyo Company, Limited patent solves the following problem:

Japanese Patent No. 3209946 (Patent Document 1) discloses compounds with neuraminidase inhibitory activity, including the compound represented by formula (I) shown below. The compound represented by formula (I) have excellent neuraminidase inhibitory activity and is expected to be useful as a drug for treating and preventing influenza virus infection. Japanese Patent No. 4205314 (Patent Document 2) revealed a concentration of the compound represented by formula (I) can remain on for a long time in the respiratory tissues like lung (Patent Document 2).

Our analysis of this patent is as follows:

Daiichi Sankyo Company, Limited’s patent US 9339487 B2 deals with Dry powder pharmaceutical composition for inhalation.
There was a dry powder pharmaceutical composition for inhalation is useful for preventing and / or treating influenza virus infections included as a medicinal component of a compound represented by formula (I): and optionally a compound represented by formula (II): a pharmacologically acceptable salt thereof, or a hydrate thereof.

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Information environment map

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The Domo, Inc. patent solves the following problem:

Our analysis of this patent is as follows:

Domo, Inc.’s patent US 9299170 B1 deals with Information environment map.
Information presented on a map like a map of the city, with the relevant information to different groups of neighborhoods. Such a display method takes advantage of spatial cognition to provide an organizational and presentational devices that users can more easily remember where to look and find the right information. Metadata, notifications, and / or other auxiliary information may be presented with or cast on the data itself.

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Aminopyrimidines as Syk inhibitors

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The Merck Sharp & Dohme Corp. patent solves the following problem:

Spleen Tyrosine Kinase (SYK) is a protein tyrosine kinase described as a key mediator of immunoreceptor signaling a host of inflammatory cells including mast cells, B-cells, macrophages and neutrophils. These immunoreceptors, including Fc receptor and the B-cell receptor, is important for allergic diseases, and antibody-mediated autoimmune diseases and thus, pharmacologically interfering with SYK conceivably treat these diseases.

Our analysis of this patent is as follows:

Merck Sharp & Dohme Corp.’s patent US 9290490 B2 deals with Aminopyrimidines as Syk inhibitors.
The present invention provides new pyrimidine amines of formula I are potent inhibitor of spleen tyrosine kinase, and is useful in the treatment and prevention of diseases mediated by said enzyme, such as asthma, COPD, rheumatoid arthritis and cancer.

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Air fairing for frameless trailer

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The Mac Trailer Manufacturing, Inc. patent solves the following problem:

The present invention relates generally to systems and devices that increase aerodynamic efficiency. Particularly, the invention relates generally to a wind fairing or trailer skirts on trailers. In particular, the invention relates to an air fairing for a frameless trailer.

Our analysis of this patent is as follows:

Mac Trailer Manufacturing, Inc.’s patent US 9283998 B2 deals with Air fairing for frameless trailer.
An air fairing device connected to the bottom under a frameless trailer improve flight efficiency and improve fuel economy. A picture of the wind fairing device provides a wind deflector position ahead of a trolley that supports the frameless trailer on a back end. The second image in the air fairing device provides two things mounted under the frameless trailer. The first deflector is attached and handed down from one sustain arm, said arm connecting the trailer of a semi-tractor or truck. The second deflector connected below the bottom of the frameless trailer and positioned behind the first deflector and the side of the trolley. A third image is similar to the second, but further includes a third deflector positioned between the two axles of the trolley.

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Dynamic expansion of data visualizations

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The Domo, Inc. patent solves the following problem:

Our analysis of this patent is as follows:

Domo, Inc.’s patent US 9202297 B1 deals with Dynamic expansion of data visualizations.
A user can dynamically present and control the performance of secondary visualizations of data based on a selected element in a main data-aw. Introduction of secondary data visualizations presented as the user interact with the first look. In response to user input, the introduction can be dynamically expanded, allowing a user to dynamically drill down to select the elements in the first data-aw. Any input mechanisms should be used, including for example, an action like a two-finger spreading in motion to celebrate the introduction in secondary visualizations, where the axis defined by two point of contact determines that showed advanced secondary visualizations highlighted and / or expanded. In various embodiments, a hierarchy of visualizations can be strengthened, and the user can navigate between the two or more levels of interactive visualizations same way.

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Drag reduction of a tractor trailer using guide vanes

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The Clarkson University patent solves the following problem:

The present invention relates to a vehicle with a gear mounted thereon for reducing aerodynamic drag and, particularly, to a guide vane device with an airfoil cross-section mounted on the aft part of a a tractor trailer.

Our analysis of this patent is as follows:

Clarkson University’s patent US 9139238 B2 deals with Drag reduction of a tractor trailer using guide vanes.
The present invention relates to a vehicle with a gear mounted thereon for reducing aerodynamic drag and, particularly, to a guide vane device with an airfoil cross-section mounted on the aft part of a a tractor trailer.

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Bifidobacterium for dust mite allergy

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The N.V. Nutricia patent solves the following problem:

House dust mite (Dermatophagoides) allergy is a hypersensitive reaction to proteins in the elimination of house dust mites and can result in respiratory insufficiencies as airway obstruction and bronchial hyperreactivity. The hypersensitivity reaction is called dust mite induced respiratory lack of this document. House dust mites found in almost all households. The elimination products of dust mites can be a serious threat to the said sensitive products as well as elimination of critical ill patients. The dust mites are not visible to the unaided eye, and thus difficult to identify in the house.

Our analysis of this patent is as follows:

N.V. Nutricia’s patent US 9119414 B2 deals with Bifidobacterium for dust mite allergy.
A composition comprising Bifidobacterium breve for use in improving lung function in human subjects suffering from dust mite allergies.

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Extended graphics context with common compositing

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The Z124 patent solves the following problem:

This relates generally to the field of mobile environments Computing, and especially to support many user environment through the use of multiple operating systems on a single mobile computing device.

Our analysis of this patent is as follows:

Z124’s patent US 9077731 B2 deals with Extended graphics context with common compositing.
Cross-around providing support and companionship user to provide a seamless computing experience in a multi-operating system environment Computing. The multi-operating system computing environments may include a mobile operating system and a desktop operating system running simultaneously and independently on a mobile device Computing. The mobile operating system may be associated with a first user environment and desktop operating systems may be associated with a second user environment. Real-time display of the applications running on the mobile operating system in the second user environment provided by the translation application with a high graphics context of mobile operating systems. Using graphic for many applications translated into about a graphics frame. The mobile computing device may be a smartphone running the Android mobile operating system and a complete desktop Linux distribution on a modified Android kernel.

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Application mirroring using multiple graphics contexts

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The Z124 patent solves the following problem:

This relates generally to the field of mobile environments Computing, and especially to support many user environment through the use of multiple operating systems on a single mobile computing device.

Our analysis of this patent is as follows:

Z124’s patent US 9060006 B2 deals with Application mirroring using multiple graphics contexts.
Cross-around providing support and companionship user to provide a seamless computing experience in a multi-operating system environment Computing. Cross-around naked provides real-time display of the application running on a mobile operating system that is shown in an environment of a desktop operating system. The mobile operating systems and desktop operating system will be running simultaneously and independently on a shared grain on a mobile device Computing. A graphic server mobile operating system in tears and rebuilds the rendering context for each application as it mixed information face. The rendering context can be strengthened to match the resolution of the associated display, so the graphics are rendered appropriate for resolution. The mobile computing device may be a smartphone running the Android mobile operating system and a complete desktop Linux distribution on a modified Android kernel.

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