Polymorphic crystal forms of 5-(2-{[6-(2,2-difluoro-2-phenylethoxy)hexyl]amino}-1-(R)-hydroxyethyl)-8-hydroxyquinolin-2(1H)-one, heminapadisytlate as agonist of the 2 adrenergic receptor

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The Almirall, S.A. patent solves the following problem:

5- (2 – {[6- (2,2-difluoro-2-phenylethoxy) hexyl] amino} -1 (R) -hydroxyethyl) -8-hydroxyquinolin-2 (1H) -one (Compound I) is a valiant 2 adrenoceptor agonist first disclosed in WO 2006/122788. This compound of the following chemical formula.

Our analysis of this patent is as follows:

Almirall, S.A.’s patent US 9346759 B2 deals with Polymorphic crystal forms of 5-(2-{[6-(2,2-difluoro-2-phenylethoxy)hexyl]amino}-1-(R)-hydroxyethyl)-8-hydroxyquinolin-2(1H)-one, heminapadisytlate as agonist of the 2 adrenergic receptor.
The present invention is directed to novel polymorphic crystalline form of a 5- (2 – {[6- (2,2-difluoro-2-phenylethoxy) hexyl] amino} -1- (R) -hydroxyethyl) -8-hydroxyquinolin- 2 (1H) -one, heminapadisylate. invention is also directed to pharmaceutical compositions comprising said polymorphic crystalline forms, ways to use them to treat respiratory diseases associated with 2 adrenergic receptor activity and a process to prepare the polymorphic crystalline forms.

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High energy liquid enteral nutritional composition

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The N.V. Nutricia patent solves the following problem:

The present invention relates in general to a liquid enteral composition for providing nutrition, or as a supplement, or as a complete nutrition, with a high energy inside.

Our analysis of this patent is as follows:

N.V. Nutricia’s patent US 9345256 B2 deals with High energy liquid enteral nutritional composition.
High energy and high protein liquid nutrition enteral composition which includes micellar casein and caseinate, a optionally a small amount of whey.

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Halogen-free, fireproof, transparent thermoplastic compositions having high thermomechanical strength, in particular for encapsulation in photovoltaic modules

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The Arkema France patent solves the following problem:

Our analysis of this patent is as follows:

Arkema France’s patent US 9331215 B2 deals with Halogen-free, fireproof, transparent thermoplastic compositions having high thermomechanical strength, in particular for encapsulation in photovoltaic modules.
A transparent, fireproof thermoplastic composition which is free from halogen compounds and include a polyamide-block graft copolymer formed a polyolefin backbone and, on average, at least one polyamide graft. The grafts attached to the backbone by the radicals of an unsaturated monomer (X) has a function able to react in a polyamide, and the radicals of the unsaturated monomer (X) is attached to the roots the backbone by grafting or co-polymerisation of the double bond. composition includes, as a weight percentage of the total composition: 90 to 99 wt% of polyamide-block graft copolymer, and 1 to 10 wt% of metal salts of phosphoric acid.

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2-Pyridyl carboxamide-containing spleen tyrosine kinase (SYK) inhibitors

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The Merck Sharp & Dohme Corp. patent solves the following problem:

Spleen Tyrosine Kinase (SYK) is a protein tyrosine kinase described as a key mediator of immunoreceptor signaling a host of inflammatory cells including mast cells, B-cells, macrophages and neutrophils. These immunoreceptors, including Fc receptor and the B-cell receptor, is important for allergic diseases, and antibody-mediated autoimmune diseases and thus pharmacologically interfering SYK conceivably treat these diseases.

Our analysis of this patent is as follows:

Merck Sharp & Dohme Corp.’s patent US 9216173 B2 deals with 2-Pyridyl carboxamide-containing spleen tyrosine kinase (SYK) inhibitors.
invention provides certain 2-pyridyl formamide-containing compounds of Formula (I) or pharmaceutically acceptable salts thereof, wherein A and B as described here. invention also provides pharmaceutical compositions comprising such compounds, and methods of using the compounds for treating diseases or conditions mediated spleen tyrosine kinase (SYK) kinase.

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Wear and friction properties of engineering thermoplastics with ultra-high molecular weight polyethylene

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The Sabic Global Technologies B.V. patent solves the following problem:

Ultra-high molecular weight polyethylene (UHMWPE) has a very high melt viscosity that makes conventional processing techniques such as screw extrusion and injection molding difficult to fulfill. Thus, the use of UHMWPE limited. Polyetherimide (PEI), and polyetheretherketone (Peek) is used in a variety of lubricated applications such as gears, bearings, and rollers, for example.

Our analysis of this patent is as follows:

Sabic Global Technologies B.V.’s patent US 9181430 B2 deals with Wear and friction properties of engineering thermoplastics with ultra-high molecular weight polyethylene.
Said here is the composition comprising a polymer comprising polyetherimide, polyetheretherketone, polyamide, polyoxyalkylene or polyalkylene terephthalate, or a mixture thereof, and ultra-high molecular weight polyethylene, where the ultra- high molecular weight polyethylene covers a surface modifier. Also disclosed are articles containing one or more of the species composition. abstract It is intended as a scanning tool for purposes of searching in the particular art and is not intended to limit the present invention.

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Bipyridylaminopyridines as Syk inhibitors

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The Merck Sharp & Dohme Corp., , Merck Canada Inc. patent solves the following problem:

Spleen Tyrosine Kinase (SYK) is a protein tyrosine kinase described as a key mediator of immunoreceptor signaling a host of inflammatory cells including mast cells, B-cells, macrophages and neutrophils. These immunoreceptors, including Fc receptor and the B-cell receptor, is important for allergic diseases, and antibody-mediated autoimmune diseases and thus pharmacologically interfering SYK conceivably treat these diseases.

Our analysis of this patent is as follows:

Merck Sharp & Dohme Corp., , Merck Canada Inc.’s patent US 9145391 B2 deals with Bipyridylaminopyridines as Syk inhibitors.
The present invention provides new pyrimidine amines of formula I are potent inhibitor of spleen tyrosine kinase, or prodrugs thereof, and useful in the treatment and prevention of diseases mediated by said enzyme, such as asthma, COPD and rheumatoid arthritis and cancer.

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Nutritional formulation for promoting catch-up growth

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The Nestec S.A. patent solves the following problem:

It has been recognized for many years that the growth pattern of young mammals who suffer stress as a result of physical illness or injury or psychological trauma is often interrupted. If the young mammal a swift recovery and adequate nutrition is, then it can compensate for the growth that occurred during the period of stress and this sudden rapid growth known arrest growth. However, this does not always happen. For example, the young mammal may suffer from anorexia both during the illness or injury and his immediate human food and may therefore be limited. In severe cases these animals never reach the physical size that it would have reached a pressure not suffered.

Our analysis of this patent is as follows:

Nestec S.A.’s patent US 9144250 B2 deals with Nutritional formulation for promoting catch-up growth.
This invention relates to a nutritional formulation comprising a N3 long-chain polyunsaturated fatty acid (LC-PUFA), a prebiotic fiber and a probiotic bacterial strain mixture act in a synergistic way promote footage growth in young mammals whose growth has to be wrong because the young mammal has been subjected to physical or mental stress.

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Dual display pinyin touch input

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The Z124 patent solves the following problem:

A substantial number of handheld devices Computing, such as cellular phones, tablets, and E-Readers, make use of a touch screen display will not only save the display information to the user, but also to take inputs from the user's command interface. While touch screen display can increase the configurability of the handheld device and to provide a wide variety of user interface options, this flexibility often comes at a price. The two use the touch screen to provide for and receive user commands, while flexible for the user, in order to obfuscate the display, and cause visual clutter, thus leading to user frustration and loss of yield.

Our analysis of this patent is as follows:

Z124’s patent US 9128660 B2 deals with Dual display pinyin touch input.
These methods and devices including providing a device having at least a first screen and a secondary screen; receiving a first input, where the first input comprising a Pinyin input on the first screen; processing the first input to estimate a character based on previous input; to display the estimated character (s); and to exercise a choice, where the selection includes a choice of traits selected from the estimated character (s).

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Pyridyl aminopyridines as Syk inhibitors

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The Merck Sharp & Dohme Corp. patent solves the following problem:

Spleen Tyrosine Kinase (SYK) is a protein tyrosine kinase described as a key mediator of immunoreceptor signaling a host of inflammatory cells including mast cells, B-cells, macrophages and neutrophils. These immunoreceptors, including Fc receptor and the B-cell receptor, is important for allergic diseases, and antibody-mediated autoimmune diseases and thus pharmacologically interfering SYK conceivably treat these diseases.

Our analysis of this patent is as follows:

Merck Sharp & Dohme Corp.’s patent US 9120785 B2 deals with Pyridyl aminopyridines as Syk inhibitors.
The present invention provides new pyrimidine amines of formula I are potent inhibitor of spleen tyrosine kinase, and is useful in the treatment and prevention of diseases mediated by said enzyme, such as asthma, COPD, rheumatoid arthritis, and cancer .

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Extended graphics context with common compositing

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The Z124 patent solves the following problem:

This relates generally to the field of mobile environments Computing, and especially to support many user environment through the use of multiple operating systems on a single mobile computing device.

Our analysis of this patent is as follows:

Z124’s patent US 9077731 B2 deals with Extended graphics context with common compositing.
Cross-around providing support and companionship user to provide a seamless computing experience in a multi-operating system environment Computing. The multi-operating system computing environments may include a mobile operating system and a desktop operating system running simultaneously and independently on a mobile device Computing. The mobile operating system may be associated with a first user environment and desktop operating systems may be associated with a second user environment. Real-time display of the applications running on the mobile operating system in the second user environment provided by the translation application with a high graphics context of mobile operating systems. Using graphic for many applications translated into about a graphics frame. The mobile computing device may be a smartphone running the Android mobile operating system and a complete desktop Linux distribution on a modified Android kernel.

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