Phenyl carboxamide-containing spleen tyrosine kinase (SYK) inhibitors

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The Merck Sharp & Dohme Corp. patent solves the following problem:

Spleen Tyrosine Kinase (SYK) is a protein tyrosine kinase described as a key mediator of immunoreceptor signaling a host of inflammatory cells including mast cells, B-cells, macrophages and neutrophils. These immunoreceptors, including Fc receptor and the B-cell receptor, is important for allergic diseases, and antibody-mediated autoimmune diseases and thus pharmacologically interfering SYK conceivably treat these diseases.

Our analysis of this patent is as follows:

Merck Sharp & Dohme Corp.’s patent US 9006444 B2 deals with Phenyl carboxamide-containing spleen tyrosine kinase (SYK) inhibitors.
invention provides certain phenyl formamide-containing compounds of Formula (I); or pharmaceutically acceptable salts thereof, wherein A and B as described here. invention also provides pharmaceutical compositions comprising such compounds, and methods of using the compounds for treating diseases or conditions mediated spleen tyrosine kinase (SYK) kinase.

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Crash sensor systems utilizing vehicular inertial properties

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The Automotive Technologies International, Inc. patent solves the following problem:

Our analysis of this patent is as follows:

Automotive Technologies International, Inc.’s patent US 8914196 B1 deals with Crash sensor systems utilizing vehicular inertial properties.
Electronic crash sensor system for a vehicle including at least one inertial measurement device arranged in the vehicle to measure the inertial properties of the car, a processor that includes or works in a crash sensing algorithm that determines the vehicle detect a crash based on the inertial properties measured in each inertial measurement device and a positioning system arranged in the vehicle position to provide it. The inertial properties measured by each inertial measurement device modified base position and then given to the crash sensing algorithm so that the crash sensing algorithm determines if the vehicle detect a crash based on modified inertial properties measured by each inertial measurement device. Self-testing device in every inertial measurement is made.

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Lid for closing a cup

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The Constantia Teich Gmbh patent solves the following problem:

Our analysis of this patent is as follows:

Constantia Teich Gmbh’s patent US 8905251 B2 deals with Lid for closing a cup.
A lid (2) for the end of a cup (1) by a peripheral sealing edge (10) and a method for the production of such a lid. lid includes at least one aluminum film and an optionally multi-layered plastic layer that is co-extruded film to aluminum and has a closed predetermined tear lines (3). The plastic layer made of plastic based on polyethylene (PE) or plastic based on polypropylene (PP), and the predetermined tearing line introduced into the plastic layer preferably with a CO2 laser. The predetermined tear lines (3) can be given directly to the sealing edge region (10).

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Nasal administration

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The Optinose As patent solves the following problem:

Our analysis of this patent is as follows:

Optinose As’s patent US 8875704 B2 deals with Nasal administration.
A delivery device and method to deliver a powdered substance, in particular a triptan, such as sumatriptan, the anal region of a nasal cavity of a subject, in particular for the treatment of headache head, for example, cluster headaches and migraine, and neuropathic pain, the delivery device comprising: a nosepiece for insertion into a nasal cavity of a subject with which the powdered substance delivered to the posterior region of the nasal cavity of the subject, in particular on the bottom two thirds of the nasal cavity; and a substance supply unit that is operable to deliver the powdered substance through the nosepiece.

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Low-caloric high-protein nutritional composition for the stimulation of muscle protein synthesis

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The N.V. Nutricia patent solves the following problem:

Age-related volunteers loss of muscle mass and strength occurs during the ages and is called sarcopenia [1]. As the degenerative loss of skeletal muscle mass, it occurs at a rate of 3-8% per decade after the age of 30 years, and accelerate from 60 years of age. The two impaired muscle mass and muscle strength associated with age-related loss of muscle function.

Our analysis of this patent is as follows:

N.V. Nutricia’s patent US 8846759 B2 deals with Low-caloric high-protein nutritional composition for the stimulation of muscle protein synthesis.
The present invention relates to the use of a low-caloric high-protein nutritional composition for use in the prevention or treatment of a disease or condition in a mammal, including muscle decline, as well as specific low-caloric high-protein nutritional composition for stimulating muscle protein synthesis in a mammal. In particular, the invention relates to the use of a nutritional composition comprising per 100 kcal: (i) at least 12 g of proteinaceous matter comprising at least about 80 weight% of whey protein, relative to total proteinaceous matter, and containing at least 11 weight% of leucine, relative to the total proteinaceous matter, at least 20 weight% in a free form, relative to the total leucine, ( ii) a source of fat and a source of digestible carbohydrates, for the prevention or treatment of a disease or condition involving reduced muscle in a mammal, especially in an old mammal, which nutritional composition administered as 1 to 2 servings daily, each serving consisting of between 80 and 200 kcal.

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Cross-environment communication using application space API

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The Z124 patent solves the following problem:

This relates generally to the field of mobile environments Computing, and especially to support many user environment through the use of multiple operating systems on a single mobile computing device.

Our analysis of this patent is as follows:

Z124’s patent US 8726294 B2 deals with Cross-environment communication using application space API.
A mobile computing devices with a mobile operating systems and desktop operating systems running simultaneously and independently on a shared grain without virtualization. The mobile operating system provides a mobile user experience as the desktop operating system provides a complete desktop user experience when the mobile computing device is docked to a secondary terminal environment. Applications in desktop operating systems to communicate with applications and services in the mobile operating system with a framework cross-communication environment. The cross-premises communication structure may include application programming interfaces through which categories of applications communicate across a multiple computing environment operating system through category-specific calls remote communication. The mobile computing device may be a smartphone running the Android mobile operating system and a complete desktop Linux distribution on a modified Android kernel.

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Compositions comprising signal peptide-containing proteins

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The Incyte Corporation patent solves the following problem:

Protein transport is essential for cellular function. Transport in a protein may be mediated by a peptide signal located at the amino terminal protein itself. The signal peptide consists of ten to twenty hydrophobic amino acids that target the nascent protein from ribosome to a particular membrane bound compartment such as the endoplasmic reticulum (ER). Protein target the ER to continue by way secretory or stay in any of the secretory organelles such as the ER, Golgi apparatus, or lysosomes. Proteins that transit through the secretory way be secreted into the extracellular space or left in the plasma membrane. Secreted proteins are often synthesized as inactive precursors because of the post-translation processing events during transit through the secretory way. Such events include glycosylation, phosphorylation, proteolysis, and removal of the signal peptide with a signal peptidase. The other events that occur during the transport proteins include chaperone-dependent expression and folding of nascent proteins and protein interaction with a receptor or pore complex. Examples of secreted proteins with amino terminal signal peptide described below and include the receptor, extracellular matrix molecules, cytokines, hormones, growth and diversity factor, neuropeptides, vasomediators, phosphokinases, phosphatases, phospholipases, phosphodiesterases, G and Ras-related protein, Ion channels, pedagogue / pump, proteases, and transcription factors. (Reviewed in Alberts, B. et al. (1994) Molecular Biology of the Cell, garland Publishing, New York, NY, pp. 557-560, 582-592.)

Our analysis of this patent is as follows:

Incyte Corporation’s patent US 8716445 B2 deals with Compositions comprising signal peptide-containing proteins.
human invention provides signal peptide-containing proteins (HSPP) and polynucleotides which identify and encode HSPP. invention also provides expression vector, host cells, antibodies, agonists and antagonists. invention also provides methods for diagnosing, treating, or preventing diseases associated with expression of HSPP.

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Methods of using BTL-II proteins

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The Immunex Corporation patent solves the following problem:

Modulation of an immune or inflammatory response can be a valuable tool to control various types of diseases including autoimmune diseases, diseases characterized by abnormal inflammation and / or immune response, and infections . In treating diseases characterized by abnormal inflammation and / or immune responses, such as inflammatory bowel disease and autoimmune or inflammatory diseases, modulation of an immune response is desirable. In other situations, for example when the vaccine to a patient to give immunity to an infectious disease, stimulation of an immune response is desirable. In the case of vaccines, adjuvants on an immune response to a coadministered antigen can be valuable in providing long term protection against the disease. Particularly lacking in the art is the adjuvants capable of stimulating a mucosal immune response. A mucosal immune response, as opposed to a systemic immune response, is valuable because it attacks an infection with a very common point of entry, that is, to a mucosal surface. The present invention addresses these needs in the art by providing therapeutic agents for the diagnosis and treatment of diseases characterized by inadequate and / or abnormal inflammation and / or immune response and therapeutic agents that act as adjuvants to stimulate an immune response, particularly a mucosal immune response.

Our analysis of this patent is as follows:

Immunex Corporation’s patent US 8674078 B2 deals with Methods of using BTL-II proteins.
invention provides isolated BTL-II protein, nucleic acid, antibody, enemies, and agonists and methods of making and using the same. Diagnostic, screening, and therapeutic methods of using the compositions of the invention given. For example, the composition of the invention can be used for diagnosis and treatment of inflammatory intestinal diseases and for the development of a mucosal immune response to an antigen.

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7-(1H-pyrazol-4-yl)-1,6-naphthyridine compounds as Syk inhibitors

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The Glaxo Group Limited patent solves the following problem:

Our analysis of this patent is as follows:

Glaxo Group Limited’s patent US 8633319 B2 deals with 7-(1H-pyrazol-4-yl)-1,6-naphthyridine compounds as Syk inhibitors.
The present invention relates to a compound of formula (I): or a salt thereof; which is an inhibitor of spleen tyrosine kinase (SYK) and therefore potential use in the treatment of diseases resulting from inappropriate activation of mast and / or basophil cells, macrophages, and B-cells and related inflammatory response and tissue damage, for example, inflammatory disease, and / or allergic disorders, and cancer therapy, especially heme malignancies, chronic spontaneous urticaria and autoimmune conditions.

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Secure virtualization environment bootable from an external media device

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The Citrix Systems, Inc. patent solves the following problem:

As the number of mobile employees, remote employees, guests and employees role-based employees increases, so the demand for computing systems that restrict the information contained in each type of employee, and shut personal data an employee from the work-related data. Many companies give their employees with laptops, remote access to the company Intranet, remote access to applications used by an employee, remote access to files on an employee, and access to remote desktop, virtual machine, or remote applications. In many instances, employees have access to company resources from any location, using any machine and / or network.

Our analysis of this patent is as follows:

Citrix Systems, Inc.’s patent US 8560826 B2 deals with Secure virtualization environment bootable from an external media device.
Methods and systems for creating a secure virtualization environment on a host of devices, without modification to the host device, secure virtualization environment bootable from an external media device. A host of computation load device and boots on a common operating system image stored on an external media device. A client agent stored on external media device and comply with the common operating system creates an adapted operating system image by copying the operating system of the device hosts Computing, removing all unnecessary files and data and storing the adapted operating system images on external media device. The host computing device provides a secure virtualized environment by pregnant adapted operating system images.

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