BTK inhibitors

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The Merck Sharp & Dohme Corp. patent solves the following problem:

B lymphocyte activation is key to the generation of adaptive immune responses. Derailed B lymphocyte activation is a sign of many autoimmune diseases and in the modulation of the immune response and therapeutic interest. Recently the success of B cell therapy in autoimmune disease is established. Treatment of rheumatoid arthritis (RA) patients with Rituximab (anti-CD20 therapy) is an accepted clinical therapy today. More recent clinical trial studies showed that treatment with Rituximab also ameliorates symptoms of the disease in relapsing remitting multiple sclerosis (RRMS) and systemic lupus erythematosus (murder) patients. This success supports the potential for future therapies for autoimmune diseases targeted B cell immunity.

Our analysis of this patent is as follows:

Merck Sharp & Dohme Corp.’s patent US 9446130 B2 deals with BTK inhibitors.
The present invention provides Bruton's tyrosine kinase (Btk) inhibitor compounds according to Formula I or pharmaceutically acceptable salt thereof. Formula I or a pharmaceutically acceptable salt thereof or pharmaceutical compositions comprising these compounds and their use in therapy. In particular, the present invention relates to the use of Btk inhibitor compounds for the treatment of Btk mediated disorder.

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Compounds

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The Glaxo Group Limited patent solves the following problem:

Syk is a non-receptor tyrosine kinase involved in coupling activated immunoreceptors signal consuming events that mediate diverse cellular responses, including proliferation, distinction, and phagocytosis. Syk is widely expressed in hematopoietic cells. Syk inhibitor with potential anti-inflammatory and immunomodulating activities. They inhibit SYK-mediated IgG Fc epsilon and gamma receptor and BCR receptor signaling, resulting in inhibition of activation of mast cells, macrophages, and B-cells and relevant inflammatory responses and tissue damage. Mast cells play a major role in type I hypersensitivity reactions associated with urticaria, bronchial asthma, anaphylaxis and other allergic conditions. Therefore, SYK inhibitor has attracted interest from a number of therapeutic areas, including the treatment of rheumatoid arthritis, B-cell lymphoma, asthma, rhinitis and cutaneous disorders such as acute and chronic urticaria, mastocytosis, cutaneous lupus , atopic dermatitis, autoimmune bullous conditions including Pemphigus and pemphigoid and other mast cell mediated skin disease.

Our analysis of this patent is as follows:

Glaxo Group Limited’s patent US 9447074 B2 deals with Compounds.
A compound of formula (I): or a salt thereof; which is an inhibitor of spleen tyrosine kinase (SYK) and therefore potential use in the treatment of diseases resulting from inappropriate activation of mast cells, macrophages, and B-cells and related inflammatory responses and tissue damage, for example inflammatory diseases and / or allergic conditions, in cancer therapy, especially heme malignancies, and autoimmune conditions.

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User interface with independent drawer control

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The Z124 patent solves the following problem:

While the computing and communications functions for handheld devices Computing becomes more powerful, the user interface and display elements such devices have evolved by trying to adapt user interface regime for the personal computer for use in handheld devices Computing . However, this attempt to adapt the user interface of the regime met with various obstacles.

Our analysis of this patent is as follows:

Z124’s patent US 9405444 B2 deals with User interface with independent drawer control.
Methods and apparatus for controlling the display of one or more drawers with a user interface to provide a new user interface interaction. The drawers can be opened in response to a motion input to display the data announcement, application data, contact data, calendar data, weather data, and the drawers can be opened and / or closed individually or collectively. For example, a character in action (eg, a place of action) may determine that the drawer was opened in response to the motion input.

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Polymorphic crystal forms of 5-(2-{[6-(2,2-difluoro-2-phenylethoxy)hexyl]amino}-1-(R)-hydroxyethyl)-8-hydroxyquinolin-2(1H)-one, heminapadisytlate as agonist of the 2 adrenergic receptor

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The Almirall, S.A. patent solves the following problem:

5- (2 – {[6- (2,2-difluoro-2-phenylethoxy) hexyl] amino} -1 (R) -hydroxyethyl) -8-hydroxyquinolin-2 (1H) -one (Compound I) is a valiant 2 adrenoceptor agonist first disclosed in WO 2006/122788. This compound of the following chemical formula.

Our analysis of this patent is as follows:

Almirall, S.A.’s patent US 9346759 B2 deals with Polymorphic crystal forms of 5-(2-{[6-(2,2-difluoro-2-phenylethoxy)hexyl]amino}-1-(R)-hydroxyethyl)-8-hydroxyquinolin-2(1H)-one, heminapadisytlate as agonist of the 2 adrenergic receptor.
The present invention is directed to novel polymorphic crystalline form of a 5- (2 – {[6- (2,2-difluoro-2-phenylethoxy) hexyl] amino} -1- (R) -hydroxyethyl) -8-hydroxyquinolin- 2 (1H) -one, heminapadisylate. invention is also directed to pharmaceutical compositions comprising said polymorphic crystalline forms, ways to use them to treat respiratory diseases associated with 2 adrenergic receptor activity and a process to prepare the polymorphic crystalline forms.

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Wear and friction properties of engineering thermoplastics with ultra-high molecular weight polyethylene

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The Sabic Global Technologies B.V. patent solves the following problem:

Ultra-high molecular weight polyethylene (UHMWPE) has a very high melt viscosity that makes conventional processing techniques such as screw extrusion and injection molding difficult to fulfill. Thus, the use of UHMWPE limited. Polyetherimide (PEI), and polyetheretherketone (Peek) is used in a variety of lubricated applications such as gears, bearings, and rollers, for example.

Our analysis of this patent is as follows:

Sabic Global Technologies B.V.’s patent US 9181430 B2 deals with Wear and friction properties of engineering thermoplastics with ultra-high molecular weight polyethylene.
Said here is the composition comprising a polymer comprising polyetherimide, polyetheretherketone, polyamide, polyoxyalkylene or polyalkylene terephthalate, or a mixture thereof, and ultra-high molecular weight polyethylene, where the ultra- high molecular weight polyethylene covers a surface modifier. Also disclosed are articles containing one or more of the species composition. abstract It is intended as a scanning tool for purposes of searching in the particular art and is not intended to limit the present invention.

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Policy update apparatus, policy management system, policy update method, policy management method and recording medium

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The Nec Corporation patent solves the following problem:

Technology manager at a software policy that making the information into one resource is known.

Our analysis of this patent is as follows:

Nec Corporation’s patent US 9183009 B2 deals with Policy update apparatus, policy management system, policy update method, policy management method and recording medium.
The present invention provides a policy update tool to update a policy right software configuration changes equivalent to a resource. The update policy tools including policy acquisition means receives a sign resource, read an installation destination resource sign corresponding to the sign of the resources from the resource management means that by providing a mapping between signs that resources and resource-installed destinations characterizing an installation destination resource resource resource recognized the signs installed, and read the policy software corresponding to the signs and resources to install destination resource identification, and policy updates means that software update policy, gather and compare the updated software resource policy signs and install the sign destination resources, and food storage policy through.

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Cross-environment application compatibility for single mobile computing device

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The Z124 patent solves the following problem:

This relates generally to the field of mobile environments Computing, and especially to support many user environment through the use of multiple operating systems on a single mobile computing device.

Our analysis of this patent is as follows:

Z124’s patent US 9160796 B2 deals with Cross-environment application compatibility for single mobile computing device.
A seamless cross-around workflow given a multi-operating system environment Computing. The multi-operating system computing environments may include a mobile operating system and a desktop operating system running simultaneously and independently on a mobile device Computing. Two or more application programs, running the operating system independent of user interaction with the state information including user data, user settings, and / or application context information. Interaction with the state information may be shared for the applications used primarily to access and edit the user's local content as well as applications that communicate with a remote server or access and navigate other remote content ( for example, Internet-based application, browser, etc.). The mobile computing device may be a smartphone running the Android mobile operating system and a complete desktop Linux distribution on a modified Android kernel.

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Portrait dual display and landscape dual display

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The Z124 patent solves the following problem:

A substantial number of handheld devices Computing, such as cellular phones, tablets, and E-Readers, make use of a touch screen display will not only save the display information to the user, but also to take inputs from the user's command interface. While touch screen display can increase the configurability of the handheld device and to provide a wide variety of user interface options, this flexibility often comes at a price. The two use the touch screen to provide for and receive user commands, while flexible for the user, in order to obfuscate the display, and cause visual clutter, thus leading to user frustration and loss of yield.

Our analysis of this patent is as follows:

Z124’s patent US 9152179 B2 deals with Portrait dual display and landscape dual display.
Methods and devices for controlling the output shown associated with the application in connection with a large screen device given. Particularly, an application presented to the devices in a two-picture orientation used the first screen to display the control information, and use the second screen to show the inside information. An application presented to the creation of a two landscape orientation use the first screen and the second screen to show the inside information.

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Dual display cursive touch input

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The Z124 patent solves the following problem:

A substantial number of handheld devices Computing, such as cellular phones, tablets, and E-Readers, make use of a touch screen display will not only save the display information to the user, but also to take inputs from the user's command interface. While touch screen display can increase the configurability of the handheld device and to provide a wide variety of user interface options, this flexibility often comes at a price. The two use the touch screen to provide for and receive user commands, while flexible for the user, in order to obfuscate the display, and cause visual clutter, thus leading to user frustration and loss of yield.

Our analysis of this patent is as follows:

Z124’s patent US 9128659 B2 deals with Dual display cursive touch input.
These methods and devices including providing a device having at least a first screen and a secondary screen; receiving a first input, where the first input comprising a cursive input on the first screen; processing the first input to estimate a character based on previous input; to display the estimated character (s); and to exercise a choice, where the selection includes a choice of traits selected from the estimated character (s).

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Dual display pinyin touch input

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The Z124 patent solves the following problem:

A substantial number of handheld devices Computing, such as cellular phones, tablets, and E-Readers, make use of a touch screen display will not only save the display information to the user, but also to take inputs from the user's command interface. While touch screen display can increase the configurability of the handheld device and to provide a wide variety of user interface options, this flexibility often comes at a price. The two use the touch screen to provide for and receive user commands, while flexible for the user, in order to obfuscate the display, and cause visual clutter, thus leading to user frustration and loss of yield.

Our analysis of this patent is as follows:

Z124’s patent US 9128660 B2 deals with Dual display pinyin touch input.
These methods and devices including providing a device having at least a first screen and a secondary screen; receiving a first input, where the first input comprising a Pinyin input on the first screen; processing the first input to estimate a character based on previous input; to display the estimated character (s); and to exercise a choice, where the selection includes a choice of traits selected from the estimated character (s).

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