Antibodies which bind to signal peptide-containing molecules

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The Incyte Corporation patent solves the following problem:

Protein transport is essential for cellular function. Transport in a protein may be mediated by a peptide signal located at the amino terminal protein itself. The signal peptide consists of ten to twenty hydrophobic amino acids that target the nascent protein from ribosome to a particular membrane bound compartment such as the endoplasmic reticulum (ER). Protein target the ER to continue by way secretory or stay in any of the secretory organelles such as the ER, Golgi apparatus, or lysosomes. Proteins that transit through the secretory way be secreted into the extracellular space or left in the plasma membrane. Secreted proteins are often synthesized as inactive precursors because of the post-translation processing events during transit through the secretory way. Such events include glycosylation, phosphorylation, proteolysis, and removal of the signal peptide with a signal peptidase. The other events that occur during the transport proteins include chaperone-dependent expression and folding of nascent proteins and protein interaction with a receptor or pore complex. Examples of secreted proteins with amino terminal signal peptide described below and include the receptor, extracellular matrix molecules, cytokines, hormones, growth and diversity factor, neuropeptides, vasomediators, phosphokinases, phosphatases, phospholipases, phosphodiesterases, G and Ras-related protein, Ion channels, pedagogue / pump, proteases, and transcription factors. (Reviewed in Alberts, B. et al. (1994) Molecular Biology of the Cell, garland Publishing, New York, NY, pp. 557-560, 582-592.)

Our analysis of this patent is as follows:

Incyte Corporation’s patent US 9102745 B2 deals with Antibodies which bind to signal peptide-containing molecules.
human invention provides signal peptide-containing proteins (HSPP) and polynucleotides which identify and encode HSPP. invention also provides expression vector, host cells, antibodies, agonists and antagonists. invention also provides methods for diagnosing, treating, or preventing diseases associated with expression of HSPP.

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Truck fairing

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The Volvo Group North America, Llc patent solves the following problem:

From increasing fuel costs continue to encourage strict and semi-trailer tractors designers to search for additional, novel ways to improve vehicle fuel economy. Negative effects of airflow during the trip is always a place to focus, and manufacturers reduce aerodynamic drag, for example, again out forms to avoid the restraint force working directly any moving body Airstream encounter. Fairings, things, foil, covered with hoods, rolled under the bumpers, recessed door handles add to the cost of design and weight, and complicate car repair and servicing. Nevertheless, the designers' goal was to offset these negative effects to a general decrease in drag coefficient as car fuel economy may increase.

Our analysis of this patent is as follows:

Volvo Group North America, Llc’s patent US 9027686 B2 deals with Truck fairing.
A truck includes a frame, an operator cab frame, and a drive axle with a differential. differential can be connected to a drive shaft. A fairing for directing the air flow around the differential is attached to the frame before the drive axle and the front differential. fairing may have a non-deflected position and a deflected position.

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Virtual ad hoc network testbeds for network-aware applications

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The Telcordia Technologies, Inc. patent solves the following problem:

Testing and evaluation of the functional correctness and communication performance of distributed applications in the Mobile Ad hoc Network (MANETs) pose significant challenges to both feasibility and scalability. With respect to feasibility, ad hoc network hardware is always experimenting and available only in small quantities, thus facilitating evaluation of more than a few devices hardware is either infeasible or impractical for the reasons costs. With respect to scalability, running large-scale evaluation of MANETs a physical terrain very expensive in terms of logistics, so that the number of tests to be performed less often than enough .

Our analysis of this patent is as follows:

Telcordia Technologies, Inc.’s patent US 8874776 B2 deals with Virtual ad hoc network testbeds for network-aware applications.
A virtual ad hoc network testbed capacitates instrument in a testbed to support the execution of network-aware applications as is. Network aware applications are a special class of applications that interact with a network not only by using the network for communication purposes, but also to configure or read the status of network devices. Local group management gives way to automatically build standard Apis for access to information residing in a simulated or live network, and instantiate this Apis. testbed designed to connect to a standard management module (such as SNMP) and a simulation or model, starting from a MIB module. testbed uses CORBA as a communication means. The process is divided into two parts, model agent side and that side.

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Aerodynamic drag reduction device for a trailer

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The Raimund Pfaff patent solves the following problem:

This invention relates to a flying drag reduction device for a trailer, and especially flying a drag reduction device that positions the underside of the trailer forwardly rear wheel assembly to reduce the air flow impingement behind the wheel assembly.

Our analysis of this patent is as follows:

Raimund Pfaff’s patent US 8322778 B1 deals with Aerodynamic drag reduction device for a trailer.
A drag reduction device for a trailer comprising a generally U-shaped upstanding wall means having a floor and the lower ends. devices and the underside of the trailer so that the back end of the device positioned forwardly beyond the end of the rear wheel assembly of the trailer. In some photos, the device with the slider axle trailer so that the device is moved forwardly and rearwardly slider axle.

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Nutritional composition comprising immunoglobulins and oligosaccharides

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The N. V. Nutricia patent solves the following problem:

The respiratory tract and intestinal tract are common places for infection with pathogens. Despite the multitude of organisms that often have a functioning immune system, the respiratory and intestinal tract frequently become infected because they are in direct contact with the physical environment and are exposed to pathogenic microorganisms (such as virus , bacteria, protozoa, fungi, etc.) to be transmitted eg touching, the air and by eating. There are many microorganisms that cause disease in children and other people. For individuals whose immune system is compromised the risk of infection and serious illness is higher.

Our analysis of this patent is as follows:

N. V. Nutricia’s patent US 8277835 B2 deals with Nutritional composition comprising immunoglobulins and oligosaccharides.
The present invention provides a method and composition for the treatment and / or prevention of infection, said method comprising orally administering a composition to a mammal, said composition comprising a galactose having containing indigestible oligosaccharide and immunoglobulin from milk or colostrum from hyperimmunized cows.

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Robust compliant adaptive grasper and method of manufacturing same

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The President And Fellows Of Harvard College patent solves the following problem:

The present invention relates to robotic graspers or hands and, especially, a strong compliant underactuated mechanical grasper and method of manufacturing the same.

Our analysis of this patent is as follows:

President And Fellows Of Harvard College’s patent US 8231158 B2 deals with Robust compliant adaptive grasper and method of manufacturing same.
A multi-finger underactuated loud mechanical system driven by an actuator, but understood that covers a wide range of sizes, shapes, and mass. A member of the move to a link relative to a base act like a direction following a joint between the links and the base. joint has a plurality of the freedom. The number of members for removing links to loud system is less than the number of degrees of freedom in the system strong.

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Data accuracy filter for integrated emergency medical transportation database system

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The Golden Hour Data Systems, Inc. patent solves the following problem:

This invention relates to an integrated system of medical database. More specifically, this invention relates to a filter data accuracy for a medical database of emergency medical transportation industry.

Our analysis of this patent is as follows:

Golden Hour Data Systems, Inc.’s patent US 7778849 B1 deals with Data accuracy filter for integrated emergency medical transportation database system.
An integrated medical database system for business emergency medical transportation. The system includes a dispatch module, clinical module, administration module and billing module. Each module to communicate data with one or more other modules to form a system for use in data sharing, thus achieving an end-to-end automation emergency care in medical accounting. Internal consistency checks on the use of specific libraries to amend the rules on data made by the system to ensure that proper treatments made according to a choice diagnosis. The system includes a demographic filter the data the proper functioning of patient data by the billing module.

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Human protein phosphatase 2C

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The Incyte Corporation patent solves the following problem:

Change protein phosphorylation is ubiquitous methods used to control many of intracellular events in eukaryotic cells. It is estimated that more than ten percent of the active protein in a typical mammal cell are phosphorylated. Kinases to facilitate the transfer of high-energy phosphate group from adenosine triphosphate (ATP) to the target protein hydroxyamino acid residues serine, threonine, or tyrosine. Phosphatases, in contrast, take the phosphate groups. Extracellular signal including the hormone, neurotransmitter, growth and inequality factors may activate kinases, which takes place as the cell surface of cells or as activator in the final effector proteins, as well as other places along the way signal transduction. Cascade of kinases occur, as well as sensitive kinases second messenger molecules. This system allows for equipment to amplify the weak signal (lower abundance of growth factor molecules, for example), as well as the synthesis of many weak signal into an all-or-nothing answer. Phosphatases, then, is necessary to determine the extent of phosphorylation in cells and, with kinases, controlling key cellular processes such as metabolic enzyme activity, proliferation, cell growth and inequality, cell adhesion, and cell cycle progression.

Our analysis of this patent is as follows:

Incyte Corporation’s patent US 7029897 B2 deals with Human protein phosphatase 2C.
invention provides human kinases and phosphatases (KAP) and polnucleotides to recognize and encode KAP. invention also provides expresson vector, host cells, antibodies, agonists and antagonists. invention also provides methods for diagnosing, treating, or preventing diseases associated with aberrant expression of KAP.

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Microtubule-associated proteins and tubulins

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The Incyte Corporation patent solves the following problem:

The cytoskeleton, a cytoplasmic protein fiber system, mediated cell form, structure, and movement. cytoskeleton supports the cell membrane and forms tracks organelles and other elements move in the cytosol. cytoskeleton is a dynamic structure that allows the cells to adopt different forms and in obeying the action. Major cytoskeletal fibers are microfilaments, microtubules, and intermediate filaments. Motor proteins including myosin, dynein and kinesin, drive or movement along the fibers. Accessories or associated protein modification or structural strength of the fibers while cytoskeletal membrane anchors connect the fibers to the cell membrane.

Our analysis of this patent is as follows:

Incyte Corporation’s patent US 6962799 B2 deals with Microtubule-associated proteins and tubulins.
the invention provides human microtubule-associated protein and tubulins (MICAPTUB) and polynucleotides which identify and encode MICAPTUB. invention also provides expression vector, host cells, antibodies, agonists and antagonists. invention also provides methods for diagnosing, treating, or preventing diseases associated with aberrant expression of MICAPTUB.

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Integrated emergency medical transportation database system

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The Jones; Scott J., , Hutton; Kevin C. patent solves the following problem:

This invention relates to an integrated system of medical database. More specifically, this invention relates to a medical database for emergency medical transportation industry.

Our analysis of this patent is as follows:

Jones; Scott J., , Hutton; Kevin C.’s patent US 6117073 A deals with Integrated emergency medical transportation database system.
An integrated medical database system for business emergency medical transportation disclosed. The system includes a dispatch module, clinical module, administration module and billing module. Each module to communicate data with one or more other modules to form a system for use in data sharing, thus achieving an end-to-end automation emergency care in medical accounting. Internal consistency checks made by the system to ensure that proper treatments made according to a choice diagnosis.

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