Secreted proteins

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The Incyte Corporation patent solves the following problem:

Protein transport and secretion is necessary for cellular function. Transport protein mediated a signal peptide located at amino terminal protein dad or hidden. The signal peptide consists of ten to twenty hydrophobic amino acids that target the nascent protein from ribosome to a particular membrane bound compartment such as the endoplasmic reticulum (ER). Protein target the ER to continue by way secretory or stay in any of the secretory organelles such as the ER, Golgi apparatus, or lysosomes. Proteins that transit through the secretory way be secreted into the extracellular space or left in the plasma membrane. Protein retained in the plasma membrane includes one or more transmembrane domains, each consisting of 20 hydrophobic amino acid residues. Secreted protein normally synthesized as inactive precursors because of the post-translation processing events during transit through the secretory way. Such events include glycosylation, proteolysis, and removal of the signal peptide with a signal peptidase. The other events that occur during the transport proteins include chaperone-dependent expression and folding of nascent proteins and protein interaction with a receptor or pore complex. Examples of secreted proteins with amino terminal signal peptide described below and include protein with an important role in cell-to-cell signaling. Such proteins include transmembrane receptor and cell surface markers, extracellular matrix molecules, cytokines, hormones, growth and diversity factor, enzyme, neuropeptides, vasomediators, cell surface markers, and antigen recognition molecules. (Reviewed in Alberts, B. et al. (1994) Molecular Biology of the Cell, garland Publishing, New York, NY, pp. 557-560, 582-592.)

Our analysis of this patent is as follows:

Incyte Corporation’s patent US 7608704 B2 deals with Secreted proteins.
human invention provides secreted protein (SECP) and polynucleotides which identify and encode SECP. invention also provides expression vector, host cells, antibodies, agonists and antagonists. invention also provides methods for diagnosing, treating, or preventing diseases associated with aberrant expression of SECP.

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Pyrazolo[3,4-B]pyridine compounds, and their use as phosphodiesterase inhibitors

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The Glaxo Group Limited patent solves the following problem:

Our analysis of this patent is as follows:

Glaxo Group Limited’s patent US 7528148 B2 deals with Pyrazolo[3,4-B]pyridine compounds, and their use as phosphodiesterase inhibitors.
The invention relates to a compound of formula (I) or a salt thereof: where: R1 is C1-4alkyl, C1-3fluoroalkyl or (CH2) 2OH; R2 is a hydrogen atom (H), methyl or C1fluoroalkyl; R3a is a hydrogen atom (H) or C1-3alkyl; P3 is optionally substituted branched C3-6alkyl, optionally substituted C3-8cycloalkyl, optionally substituted mono-unsaturated-C5-7cycloalkenyl, optionally substituted phenyl, or an optionally substituted heterocyclic group of sub-formulas (a), (bb) or (cc): B1 and B2 independently 1 or 2; and I was O, H, SO2, or NR4; and where Het sub-formula (i), (ii), (iii), (iv) or (b): The compounds of phosphodiesterase (PDE) inhibitor, in particular PDE4 inhibitor. Also provides the use of a compound of formula (I) or a pharmaceutically acceptable salt thereof, in the making of a medication for the treatment and / or Branch Tomato with an inflammatory and / or allergic disease in a mammal such as a human, for example chronic obstructive pulmonary disease (COPD), asthma, or allergic rhinitis.

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Nucleic acid and protein homologs and uses thereof

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The Abt Holding Company patent solves the following problem:

Gene is the basic unit of information that is inherited in an organism and so many mechanisms available to ensure the stability of their ranks over many generations. These strengthen mechanisms to ensure that the order of the nucleotides that contain a gene to stay in a constant form during, and since this nucleotide sequences encoding the regulatory sequence is to determine gene expression and coding sequences that determine protein structure and function of these genetic properties also stably maintained. following the race that the gene can be distinguished based on differences in their ranks. The gene sequences to determine the expression pattern and function of the gene and the protein product, thus gene with a different order are expected to display different biological functions. The protein translated from this array of genes to serve as the foundation for building more complex structures and catalytic machinery that is the basis for metabolic, developmental and physiological processes complex organisms and life possible. The final location of these structures and their corresponding functional activity also determined the underlying gene sequences that code for their formation. New assessments of the human genome is estimated that the human genome contains approximately 140,000 genes. Although each of these sequences varied role, many of these genes can be grouped into classes based on the function of the proteins for which they encode. Instead, when a gene sequence is translated into a protein that appears to be linked to an important physiological way, it may be particularly relevant for diagnostic and therapeutic use. The recognition and functional characteristics of all of the genetic determinants of life are among the challenges in modern biology and medicine.

Our analysis of this patent is as follows:

Abt Holding Company’s patent US 7420044 B1 deals with Nucleic acid and protein homologs and uses thereof.
The present invention relates to the identification of novel nucleic acid molecules and the proteins encoded by these nucleic acid molecules, as well as their production for use as therapeutics, diagnostics and for research purposes.

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CD40-related receptor that binds CD40L

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The Incyte Corporation patent solves the following problem:

Signal transduction is the general process that cells respond to extracellular signals. Signal transduction across the plasma membrane began to bind a signal molecule, for example, a hormone, neurotransmitter, or growth factors, into a cell membrane receptor. receptor, thus activated, triggers an intracellular biochemical cascade that ends with the activation of an intracellular target molecule, such as a transcription factors. This process of signal transduction regulates all kinds of cell functions, including cell growth, inequality, and gene transcription.

Our analysis of this patent is as follows:

Incyte Corporation’s patent US 7378492 B2 deals with CD40-related receptor that binds CD40L.
Various embodiments of the invention provide human receptor-associated membrane protein (REMAP) and Q polynucleotides which identify and encode REMAP. Embodiments of the invention also giving expression vector, host cells, antibodies, agonists and antagonists. Some embodiments provide methods for diagnosing, treating, or preventing diseases associated with aberrant expression of REMAP.

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Patient identification system

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The Shamos; Morris H. patent solves the following problem:

The present invention relates to the field of patient identification, especially the methods, devices and systems to strengthen the identity of a person to receive a treatment with the patients for whom the treatment is intended.

Our analysis of this patent is as follows:

Shamos; Morris H.’s patent US 5381487 A deals with Patient identification system.
States is a way to strengthen the identity of a patient in a man receiving a treatment for said patients, by (a) obtaining a print indentification nature of said patient; (B) to obtain a print identification characteristic of said individual to whom the treatment is intended to be administered; (C) has confirmed the birth to print identification characteristics obtained from patients with print identification characteristics derived from the individual. Also disclosed that a fighting devices and systems. The device information will identify one or more than one patient.

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Composite medical information and identity card

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The Giesen Peter J Van, , Danyo J Joseph patent solves the following problem:

When the human bones of a man broken, or must be replaced with artificial parts or sections for pain because of severe bone or tissue, it is common surgical practice, in the meantime, to replace deteriorating bone or connecting unhappy members in a bone by using metal members to reconnect broken on the part of a member of the bones or replace a deteriorating part of a member of the bone.

Our analysis of this patent is as follows:

Giesen Peter J Van, , Danyo J Joseph’s patent US 5161826 A deals with Composite medical information and identity card.
A composite medical information and identity card adapted brought a man with operations that resulted in the installation of one or more metal elements in his body, when passing an inspection unit X-ray, metal results cause an alarm given. card is composite and consists of a small initial cards were shown a face with the name of the man, signs of the kind of operation, and the surgeon's name. The back of the card is laminated with little side-to-side position in one of the man's head and the X-ray of the human operation, the cards and photos sealed between two similar small plates of transparent thermoplastic film that extend beyond the edge of the card enough to be permanently heat-sealed and can be a composite card.

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Medical history card

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The Melchior P. Beller patent solves the following problem:

The present invention relates to medical record cards to provide personal medical information about a patient in times of medical emergency. In times of medical emergency, it is important for medical personnel to gain immediate access to the medical history file of a patient. Medical history of allergies, chronic diseases and conditions of the blood is usually learned before any treatment can begin as no treatment was initiated with a toxic effect because of a now present a chronic condition in patients. This information should usually be obtained without the help of patients and therefore difficult to obtain quickly when only the recognition of the patient can be determined from the license of a driver or similar recognition. To alleviate this problem, pendants and bracelets are worn by people suffering from certain conditions such as diabetes, hemophilia and antibiotic allergies. However, a need exists to provide a means for more accurate and fully describes the medical history of a man on a device that can be easily carried in all individuals.

Our analysis of this patent is as follows:

Melchior P. Beller’s patent US 4236332 A deals with Medical history card.
A medical record card which support a card containing a portion microfilm with indicia so the human eye sign for certain chronic conditions that impact emergency treatment and indicia so by using a microfilm reader the details of medical history and patient identification data. supporting card includes the code for the indicia to alert medical personnel to chronic conditions and, in addition, contains some important data, knowledge about patients and about the nature and use of medical record card.

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