Dry powder pharmaceutical composition for inhalation

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The Daiichi Sankyo Company, Limited patent solves the following problem:

Japanese Patent No. 3209946 (Patent Document 1) discloses compounds with neuraminidase inhibitory activity, including the compound represented by formula (I) shown below. The compound represented by formula (I) have excellent neuraminidase inhibitory activity and is expected to be useful as a drug for treating and preventing influenza virus infection. Japanese Patent No. 4205314 (Patent Document 2) revealed a concentration of the compound represented by formula (I) can remain on for a long time in the respiratory tissues like lung (Patent Document 2).

Our analysis of this patent is as follows:

Daiichi Sankyo Company, Limited’s patent US 9339487 B2 deals with Dry powder pharmaceutical composition for inhalation.
There was a dry powder pharmaceutical composition for inhalation is useful for preventing and / or treating influenza virus infections included as a medicinal component of a compound represented by formula (I): and optionally a compound represented by formula (II): a pharmacologically acceptable salt thereof, or a hydrate thereof.

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Composition for flexible membranes

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The Sika Technology Ag patent solves the following problem:

Our analysis of this patent is as follows:

Sika Technology Ag’s patent US 9309400 B2 deals with Composition for flexible membranes.
A composition including a styrene block copolymer, a polar-modified styrene block copolymer, plant fibers and a polyolefin strong at 25 C., and the molten body, especially the membranes, made from such compositions.

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Pyrazolyl derivatives as Syk inhibitors

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The Merck Sharp & Dohme Corp., , Merck Canada Inc. patent solves the following problem:

Spleen Tyrosine Kinase (SYK) is a protein tyrosine kinase described as a key mediator of immunoreceptor signaling a host of inflammatory cells including mast cells, B-cells, macrophages and neutrophils. These immunoreceptors, including Fc receptor and the B-cell receptor, is important for allergic diseases, and antibody-mediated autoimmune diseases and thus pharmacologically interfering SYK conceivably treat these diseases.

Our analysis of this patent is as follows:

Merck Sharp & Dohme Corp., , Merck Canada Inc.’s patent US 9242984 B2 deals with Pyrazolyl derivatives as Syk inhibitors.
The present invention provides new pyrazole derivatives of formula I are potent inhibitor of spleen tyrosine kinase, and is useful in the treatment and prevention of diseases mediated by said enzyme, such as asthma, COPD, rheumatoid arthritis, and cancer .

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Methods for promoting neuronal development and/or health

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The Mead Johnson Nutrition Company patent solves the following problem:

The brain has only 2% of the total weight of the body, but it is a difficult organ used in 30% of calories in the day and nutrients. (Harris, JJ et al, The Energetics of CNS White Matter jour Neuroscience, January 2012: 32 (1): 356-371). The human brain and nervous system begin construction early in prenatal life and the two continue to develop until the age of three. This early development may have lifelong effects on overall brain and nervous system health. Therefore, brain nutrients become important additives in the diet of infants, children and pregnant and lactating women because of their ability to improve early brain development and the prevention and protection from brain and nervous system injury or illness. Moreover, brain nutrition is important for adults, as many nutrients to the developing nervous system to repair and provide neuroprotective benefits to health.

Our analysis of this patent is as follows:

Mead Johnson Nutrition Company’s patent US 9241923 B2 deals with Methods for promoting neuronal development and/or health.
The present disclosure is directed to methods for improving neuronal health and / or development of a subject by providing nutritional composition comprising a neurologic component, wherein the neurologic component to develop the brain and nervous system development and further provide neurological protection and repair. The neurologic component may include lactoferrin, zinc sulfate, one or more organosulfur compounds, and mixtures thereof.

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Compositions having reduced frictional coefficient, method of manufacture thereof and articles comprising the same

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The Sabic Global Technologies B.V. patent solves the following problem:

It disclosure relates to compositions that reduce frictional coefficients, means to do so, and articles comprising the same.

Our analysis of this patent is as follows:

Sabic Global Technologies B.V.’s patent US 9169371 B2 deals with Compositions having reduced frictional coefficient, method of manufacture thereof and articles comprising the same.
Expressed here is a composition consisting of an organic polymer and about 2 to 10 weight percent of an ionic liquid. The ionic liquid can be a halogenated or non-halogenated ionic liquid. Also disclosed in articles made from the composition.

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Portrait dual display and landscape dual display

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The Z124 patent solves the following problem:

A substantial number of handheld devices Computing, such as cellular phones, tablets, and E-Readers, make use of a touch screen display will not only save the display information to the user, but also to take inputs from the user's command interface. While touch screen display can increase the configurability of the handheld device and to provide a wide variety of user interface options, this flexibility often comes at a price. The two use the touch screen to provide for and receive user commands, while flexible for the user, in order to obfuscate the display, and cause visual clutter, thus leading to user frustration and loss of yield.

Our analysis of this patent is as follows:

Z124’s patent US 9152179 B2 deals with Portrait dual display and landscape dual display.
Methods and devices for controlling the output shown associated with the application in connection with a large screen device given. Particularly, an application presented to the devices in a two-picture orientation used the first screen to display the control information, and use the second screen to show the inside information. An application presented to the creation of a two landscape orientation use the first screen and the second screen to show the inside information.

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Separation of screen usage for complex language input

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The Z124 patent solves the following problem:

A substantial number of handheld devices Computing, such as cellular phones, tablets, and E-Readers, make use of a touch screen display will not only save the display information to the user, but also to take inputs from the user's command interface. While touch screen display can increase the configurability of the handheld device and to provide a wide variety of user interface options, this flexibility often comes at a price. The two use the touch screen to provide for and receive user commands, while flexible for the user, in order to obfuscate the display, and cause visual clutter, thus leading to user frustration and loss of yield.

Our analysis of this patent is as follows:

Z124’s patent US 9104366 B2 deals with Separation of screen usage for complex language input.
These methods and devices including providing a device having at least a first screen and a secondary screen; receiving a first input, where the first input includes an input language on the first screen; processing the first input to estimate a character based on previous input; to display the estimated character (s); and to exercise a choice, where the selection includes a choice of traits selected from the estimated character (s).

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Process for preparing new tiotropium salts, new tiotropium salts as such and pharmaceutical compositions thereof

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The Boehringer Ingelheim International Gmbh patent solves the following problem:

Tiotropium bromide is known from European Patent Application EP 418 716 A1 and the following chemical structure:

Our analysis of this patent is as follows:

Boehringer Ingelheim International Gmbh’s patent US 8686148 B2 deals with Process for preparing new tiotropium salts, new tiotropium salts as such and pharmaceutical compositions thereof.
The invention relates to a process for preparing new tiotropium salts, these new tiotropium salts, pharmaceutical formulations containing them and their use in the preparation of a medication for the treatment of respiratory complaints, especially for the treatment of COPD (chronic obstructive pulmonary disease) and asthma.

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Devices and methods for reducing vehicle drag

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The Henderson Industries, Llc patent solves the following problem:

An ongoing effort to reduce the drag in vehicular structures is of great importance as the fuel economy will be a greater consideration in vehicular design. As the drag of a car increases, the amount of fuel needed to move vehicles also increased because of greater energy required to overcome drag. For example, it states that for a vehicle traveling at 70 mph, 65% of the total fuel consumption of the engine of the car used to overcome drag. Therefore, even a small reduction in drag experienced by a vehicle traveling at a speed of course would result in a significant improvement in fuel economy.

Our analysis of this patent is as follows:

Henderson Industries, Llc’s patent US 8251436 B2 deals with Devices and methods for reducing vehicle drag.
A car trailer is given. The car trailer includes a pair of side wall fairings with a leading edge and trailing edge. Each side wall fairing located on a different wall from the other side of the rear edge of each of the wall so that the top edge of each side wall fairing contact with the wall, and the trailing edge of each side wall fairing not contact the wall. Each side wall fairing has an upward slope and down slope. The side wall fairings can be used in one or more other components described here.

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Anhdyrous lactose agglomerates and the preparation thereof

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The Campina Nederland Holding B.V. patent solves the following problem:

Lactose is widely used as a filler, filler, binder or diluent in tablets and capsules, and to a more limited extent on the lyophilized products, baby food formula, and as a carrier dry powder inhaler. Worldwide, whispered put the needs of their lactose monographs in the identity and purity of pharmaceutical grade lactose, thereby distinguishing between lactose monohydrate and anhydrous lactose. According to these medicines, anhydrous lactose must have a water content of at most 1 wt%, and for that reason particularly useful as excipient in moisture-sensitive applications.

Our analysis of this patent is as follows:

Campina Nederland Holding B.V.’s patent US 8173173 B2 deals with Anhdyrous lactose agglomerates and the preparation thereof.
The invention relates to a process for the preparation of anhydrous lactose agglomerates, said process comprising (i) subjecting essentially anhydrous lactose primary particles comprising at least 60 wt% lactose crystals in a granulator to a wet step granulation in a temperature range of 30-100 C. using a binder solution, which granulation mass subjected to dry for at least part of steps granulation, and (ii ) after dry granulation mass. The anhydrous lactose agglomerates comprising at least 50 wt% -lactose crystallites and a total water content in the range of 0-1.0 wt%, required by the standards laid down by the whispers anhydrous lactose excipients. These agglomerates combine with excellent compactibility and flowability properties and particularly useful as excipient in moisture-sensitive applications.

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