Substituted pyridine spleen tyrosine kinase (SYK) inhibitors

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The Merck Sharp & Dohme Corp., , Merck Canada Inc. patent solves the following problem:

Spleen Tyrosine Kinase (SYK) is a protein tyrosine kinase described as a key mediator of immunoreceptor signaling a host of inflammatory cells including mast cells, B-cells, macrophages and neutrophils. These immunoreceptors, including Fc receptor and the B-cell receptor, is important for allergic diseases, and antibody-mediated autoimmune diseases and thus pharmacologically interfering SYK conceivably treat these diseases.

Our analysis of this patent is as follows:

Merck Sharp & Dohme Corp., , Merck Canada Inc.’s patent US 9376418 B2 deals with Substituted pyridine spleen tyrosine kinase (SYK) inhibitors.
invention provides certain substituted Pyridines of Formula (I) or pharmaceutically acceptable salts thereof, wherein R1, R2, P3, R4, rcy, CY, and t as described here. invention also provides pharmaceutical compositions comprising such compounds, and methods of using the compounds for treating diseases or conditions mediated spleen tyrosine kinase (SYK) kinase.

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Halogen-free, fireproof, transparent thermoplastic compositions having high thermomechanical strength, in particular for encapsulation in photovoltaic modules

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The Arkema France patent solves the following problem:

Our analysis of this patent is as follows:

Arkema France’s patent US 9331215 B2 deals with Halogen-free, fireproof, transparent thermoplastic compositions having high thermomechanical strength, in particular for encapsulation in photovoltaic modules.
A transparent, fireproof thermoplastic composition which is free from halogen compounds and include a polyamide-block graft copolymer formed a polyolefin backbone and, on average, at least one polyamide graft. The grafts attached to the backbone by the radicals of an unsaturated monomer (X) has a function able to react in a polyamide, and the radicals of the unsaturated monomer (X) is attached to the roots the backbone by grafting or co-polymerisation of the double bond. composition includes, as a weight percentage of the total composition: 90 to 99 wt% of polyamide-block graft copolymer, and 1 to 10 wt% of metal salts of phosphoric acid.

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Nutritional compositions with lipid globules with a core comprising vegetable lipids and a coating comprising phospholipids or polar lipids

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The N.V. Nutricia patent solves the following problem:

Breast-feeding is the preferred method of infant feeding. However, there are circumstances that make breast-feeding impossible or less attractive. In the case of children's formula is a good alternative. The composition of modern infant formulas is adapted in such a way that will meet many of the special nutritional needs of the fast growing and developing infant.

Our analysis of this patent is as follows:

N.V. Nutricia’s patent US 9320294 B2 deals with Nutritional compositions with lipid globules with a core comprising vegetable lipids and a coating comprising phospholipids or polar lipids.
The present invention relates to a nutritional composition for children and / or children consisting of a lipid component that has a large volume lipid globule. composition can be used to prevent obesity and / or improve body composition later in life. Said lipid component comprises 10-50 wt% vegetable lipid, and the lipid globules with a number-laden diameter up to 1.0 m and / or a diameter of 2-12 m in an amount of at least 45 vol%.

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Trailer sail

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The Vanguard National Trailer Corporation patent solves the following problem:

Fairings used to improve the aerodynamics of a vehicle and are often added to the outside of a car to reduce drag while in motion. Fairings can be added to many places in the tractor and trailers to promote the launch of these great vehicles. In the past, the fairings included front and rear of the tractor as before, on, under, and behind the trailers. Fairings also placed in front of and behind the wheels of a trailer to improve aerodynamics.

Our analysis of this patent is as follows:

Vanguard National Trailer Corporation’s patent US 9296433 B2 deals with Trailer sail.
A flexible trailer fairing for reducing aerodynamic drag in a trailer on the road revealed. A fourfold flexible fairing system can be used to reduce the drag from the trailer's landing gear and wheel assembly. Many systems in keeping with the flexible fairing teaching while continuing to use also disclosed.

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Multicomponent improved vehicle fuel economy system

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The Ekostinger, Inc. patent solves the following problem:

Now most tractor-trailers and about 6-7 mpg fuel leaving significant potential for improving fuel economy of tractor-trailers. Reduced fuel consumption of tractor-trailers that directly impact cost of transportation of goods, serving businesses and consumers alike.

Our analysis of this patent is as follows:

Ekostinger, Inc.’s patent US 9283997 B2 deals with Multicomponent improved vehicle fuel economy system.
A semitrailer consisting of a main frame with a hook, an axle assembly connected to the first frame, the axle assembly including at least two wheels in rotation on the the first frame, a fairing connected to an underside of the semitrailer intermediate hook and axle assembly, the fairing including a pair of lateral surface, a lower surface spaced from the underside semitrailer, and a first surface, wherein the first surface includes an intake openings, and where at least one of the lower face or the lateral surfaces include an exit opening, and a flow path fluidly connecting the intake openings and exit openings.

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Fiber for synthetic grass field

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The Tarkett Inc. patent solves the following problem:

Artificial grass fields (artificial turf) used for years to provide a surface that simulates natural grass. These artificial grass field there are many benefits to natural grass, and, moreover, can be installed and used in places that do not allow for natural grass fields.

Our analysis of this patent is as follows:

Tarkett Inc.’s patent US 9005723 B2 deals with Fiber for synthetic grass field.
A filament for use in an artificial grass field, where the filament has a front and a rear face and at least one of the front face and rear face includes a number of neighboring concave indentations gave general -from a first end to a second end.

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Synbiotic mixture

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The Nestec S.A. patent solves the following problem:

The human colon colony in a wide range of bacteria that have both positive and negative effects on gut physiology as well as having other systemic influences. Predominant group of bacteria found in the colon include Bacteroides, bifidobacteria, eubacteria, clostridia and lactobacilli. The bacteria present have fluctuating activities in response to substrate availability, redox potential, pH, O2 tension and distribution in the colon. In general intestinal bacteria can be divided into species that could potentially exert any harmful or beneficial effects on the host. Pathogenic effects (which can cause clostridia or Bacteroides, for example) include diarrhea, infections, liver damage, carcinogenesis and intestinal corruption. Health-promoting effects may be due to inhibition of growth and colonization of harmful bacteria, stimulation of immune functions, improve digestion and absorption of essential nutrients and synthesis of vitamins. An increase in the number and / or activity of bacteria in the genus Bifidobacterium and Lactobacillus that have health promoting properties is desirable.

Our analysis of this patent is as follows:

Nestec S.A.’s patent US 9005682 B2 deals with Synbiotic mixture.
This invention relates to a preparation containing a probiotic bacterial strain and a prebiotic mixture comprising 5-70 wt% of at least one N-acetylated oligosaccharide selected from the group consisting Ga1NAc1,3Ga11,4G1c and Ga11,6Ga1NAc1,3Ga11,4G1c, 20- 95 wt% of at least one neutral oligosaccharide selected from the group consisting Ga11,6Ga1, Ga11,6Ga11,4G1c Ga11,6Ga11,6G1c, Ga11,3Ga11,3G1c, Ga11 3Ga11,4G1c, Ga1 1,6Ga1 1,6Ga1 1, 4GIc, Ga1 1,6Ga1 1,3Ga1 1,4GIc Ga1 1,3Ga1 1,6Ga1 1,4GIc and Ga11,3Ga11,3Ga11,4G1c and 2-50 wt% at least one sialylated oligosaccharide selected from the group consisting NeuAc2,3Ga11, 4G1c and NeuAc2,6Ga11,4G1c. The invention is given to food products comprising said preparation and use in preparation for the prevention and treatment of infections.

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Low-caloric high-protein nutritional composition for the stimulation of muscle protein synthesis

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The N.V. Nutricia patent solves the following problem:

Age-related volunteers loss of muscle mass and strength occurs during the ages and is called sarcopenia [1]. As the degenerative loss of skeletal muscle mass, it occurs at a rate of 3-8% per decade after the age of 30 years, and accelerate from 60 years of age. The two impaired muscle mass and muscle strength associated with age-related loss of muscle function.

Our analysis of this patent is as follows:

N.V. Nutricia’s patent US 8846759 B2 deals with Low-caloric high-protein nutritional composition for the stimulation of muscle protein synthesis.
The present invention relates to the use of a low-caloric high-protein nutritional composition for use in the prevention or treatment of a disease or condition in a mammal, including muscle decline, as well as specific low-caloric high-protein nutritional composition for stimulating muscle protein synthesis in a mammal. In particular, the invention relates to the use of a nutritional composition comprising per 100 kcal: (i) at least 12 g of proteinaceous matter comprising at least about 80 weight% of whey protein, relative to total proteinaceous matter, and containing at least 11 weight% of leucine, relative to the total proteinaceous matter, at least 20 weight% in a free form, relative to the total leucine, ( ii) a source of fat and a source of digestible carbohydrates, for the prevention or treatment of a disease or condition involving reduced muscle in a mammal, especially in an old mammal, which nutritional composition administered as 1 to 2 servings daily, each serving consisting of between 80 and 200 kcal.

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Aminopyrimidines as Syk inhibitors

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The Merck Sharp & Dohme Corp., , Merck Canada Inc. patent solves the following problem:

Spleen Tyrosine Kinase (SYK) is a protein tyrosine kinase described as a key mediator of immunoreceptor signaling a host of inflammatory cells including mast cells, B-cells, macrophages and neutrophils. These immunoreceptors, including Fc receptor and the B-cell receptor, is important for allergic diseases, and antibody-mediated autoimmune diseases and thus pharmacologically interfering SYK conceivably treat these diseases.

Our analysis of this patent is as follows:

Merck Sharp & Dohme Corp., , Merck Canada Inc.’s patent US 8735417 B2 deals with Aminopyrimidines as Syk inhibitors.
The present invention provides new pyrimidine amines of formula (I), which is a strong inhibitor of spleen tyrosine kinase, and is useful in the treatment and prevention of diseases mediated by said enzyme, such as asthma, COPD and rheumatoid arthritis.

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Lid for closing a cup

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The Constantia Teich Gmbh patent solves the following problem:

The invention relates to a lid for closing a cup along a circumferential sealing rim where the lid comprises at least one aluminum foil and an optionally multilayer polymer coextruded films to aluminum foil and a strong -that line of weakness given the polymer film, equivalent to the introduction of claim 1.

Our analysis of this patent is as follows:

Constantia Teich Gmbh’s patent US 8652644 B2 deals with Lid for closing a cup.
A lid (2) for the end of a cup (1) by a peripheral sealing edge (10) and a method for the production of such a lid. lid includes at least one aluminum film and an optionally multi-layered plastic layer that is co-extruded film to aluminum and has a closed predetermined tear lines (3). The plastic layer made of plastic based on polyethylene (PE) or plastic based on polypropylene (PP), and the predetermined tearing line introduced into the plastic layer preferably with a CO2 laser. The predetermined tear lines (3) can be given directly to the sealing edge region (10).

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