BTK inhibitors

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The Merck Sharp & Dohme Corp. patent solves the following problem:

B lymphocyte activation is key to the generation of adaptive immune responses. Derailed B lymphocyte activation is a sign of many autoimmune diseases and in the modulation of the immune response and therapeutic interest. Recently the success of B cell therapy in autoimmune disease is established. Treatment of rheumatoid arthritis (RA) patients with Rituximab (anti-CD20 therapy) is an accepted clinical therapy today. More recent clinical trial studies showed that treatment with Rituximab also ameliorates symptoms of the disease in relapsing remitting multiple sclerosis (RRMS) and systemic lupus erythematosus (murder) patients. This success supports the potential for future therapies for autoimmune diseases targeted B cell immunity.

Our analysis of this patent is as follows:

Merck Sharp & Dohme Corp.’s patent US 9446130 B2 deals with BTK inhibitors.
The present invention provides Bruton's tyrosine kinase (Btk) inhibitor compounds according to Formula I or pharmaceutically acceptable salt thereof. Formula I or a pharmaceutically acceptable salt thereof or pharmaceutical compositions comprising these compounds and their use in therapy. In particular, the present invention relates to the use of Btk inhibitor compounds for the treatment of Btk mediated disorder.

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Neurogenesis screening method and uses thereof

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The Mead Johnson Nutrition Company patent solves the following problem:

The brain has only 2% of the total weight of the body, but it is a difficult organ used in 30% of calories in the day and nutrients. (Harris, JJ et al, The Energetics of CNS White Matter jour Neuroscience, January 2012: 32 (1): 356-371). The human brain and nervous system begin construction early in prenatal life and the two continue to develop until the age of three. This early development may have lifelong effects on overall brain and nervous system health. Therefore, brain nutrients become important additives in the diet of infants, children and pregnant and lactating women because of their ability to improve early brain development and the prevention and protection from brain and nervous system injury or illness. Moreover, brain nutrition is important for adults, as many nutrients to the developing nervous system to repair and provide neuroprotective benefits to health.

Our analysis of this patent is as follows:

Mead Johnson Nutrition Company’s patent US 9351978 B2 deals with Neurogenesis screening method and uses thereof.
If there are methods for detecting and / or evidence of neurogenesis effect on cholesterol and / or oxysterol using adipose-derived stem cells (ADSCs). Also given are the ways to promote neurogenesis in ADSCs. It also gives the approach to the use of cholesterol and / or production oxysterol for a neurologic component to be incorporated into a nutritional composition for increasing neurogenesis in a pediatric subject.

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Aerodynamic drag reducing apparatus

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The Stemco Lp patent solves the following problem:

It is known that a significant amount of aerodynamic drag created when a car traveling at velocities typical in a modern way. This is due, in large part, to areas of low pressure prompting the back of the car. The lower the pressure becomes more pronounced as airflow over the vehicle separates from the surfaces vehicles. The event airflow separation also well known in aircraft wing design and, in this case, cause the wing stop.

Our analysis of this patent is as follows:

Stemco Lp’s patent US 9346496 B2 deals with Aerodynamic drag reducing apparatus.
A flight drag reducing apparatus for use in vehicles with lower surfaces that are not streamlined. facilities include folding panels that extend rearward for use in a drag reducing configuration and crushed for use in a space saving configuration.

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Halogen-free, fireproof, transparent thermoplastic compositions having high thermomechanical strength, in particular for encapsulation in photovoltaic modules

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The Arkema France patent solves the following problem:

Our analysis of this patent is as follows:

Arkema France’s patent US 9331215 B2 deals with Halogen-free, fireproof, transparent thermoplastic compositions having high thermomechanical strength, in particular for encapsulation in photovoltaic modules.
A transparent, fireproof thermoplastic composition which is free from halogen compounds and include a polyamide-block graft copolymer formed a polyolefin backbone and, on average, at least one polyamide graft. The grafts attached to the backbone by the radicals of an unsaturated monomer (X) has a function able to react in a polyamide, and the radicals of the unsaturated monomer (X) is attached to the roots the backbone by grafting or co-polymerisation of the double bond. composition includes, as a weight percentage of the total composition: 90 to 99 wt% of polyamide-block graft copolymer, and 1 to 10 wt% of metal salts of phosphoric acid.

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Automated suggested alerts based on natural language and user profile analysis

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The Domo, Inc. patent solves the following problem:

Our analysis of this patent is as follows:

Domo, Inc.’s patent US 9235978 B1 deals with Automated suggested alerts based on natural language and user profile analysis.
An alert suggestion generator to automatically suggest alert for a user based on user input. The user input may include natural language text and / or user actions that suggestion generator able to generate alert that there is a high tendency to relate, and therefore will, to the user. Each alert will have a reason for existence as the passage of time, the measure of a numeric metric, or other factors. Each alert also has a state proclamation clear how the user is announced. The alert suggestion generator to get a user profile of the user in addition to determining how alert that is most relevant to the user. The user will be queried to confirm the alert, and the alert that they set. Partial alarm will be generated and user can be queried for the trigger condition and / or state announcement needed to complete the alert.

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2-Pyridyl carboxamide-containing spleen tyrosine kinase (SYK) inhibitors

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The Merck Sharp & Dohme Corp. patent solves the following problem:

Spleen Tyrosine Kinase (SYK) is a protein tyrosine kinase described as a key mediator of immunoreceptor signaling a host of inflammatory cells including mast cells, B-cells, macrophages and neutrophils. These immunoreceptors, including Fc receptor and the B-cell receptor, is important for allergic diseases, and antibody-mediated autoimmune diseases and thus pharmacologically interfering SYK conceivably treat these diseases.

Our analysis of this patent is as follows:

Merck Sharp & Dohme Corp.’s patent US 9216173 B2 deals with 2-Pyridyl carboxamide-containing spleen tyrosine kinase (SYK) inhibitors.
invention provides certain 2-pyridyl formamide-containing compounds of Formula (I) or pharmaceutically acceptable salts thereof, wherein A and B as described here. invention also provides pharmaceutical compositions comprising such compounds, and methods of using the compounds for treating diseases or conditions mediated spleen tyrosine kinase (SYK) kinase.

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Separation of screen usage for complex language input

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The Z124 patent solves the following problem:

A substantial number of handheld devices Computing, such as cellular phones, tablets, and E-Readers, make use of a touch screen display will not only save the display information to the user, but also to take inputs from the user's command interface. While touch screen display can increase the configurability of the handheld device and to provide a wide variety of user interface options, this flexibility often comes at a price. The two use the touch screen to provide for and receive user commands, while flexible for the user, in order to obfuscate the display, and cause visual clutter, thus leading to user frustration and loss of yield.

Our analysis of this patent is as follows:

Z124’s patent US 9104366 B2 deals with Separation of screen usage for complex language input.
These methods and devices including providing a device having at least a first screen and a secondary screen; receiving a first input, where the first input includes an input language on the first screen; processing the first input to estimate a character based on previous input; to display the estimated character (s); and to exercise a choice, where the selection includes a choice of traits selected from the estimated character (s).

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Cross-environment communication framework

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The Z124 patent solves the following problem:

This relates generally to the field of mobile environments Computing, and especially to support many user environment through the use of multiple operating systems on a single mobile computing device.

Our analysis of this patent is as follows:

Z124’s patent US 9098437 B2 deals with Cross-environment communication framework.
A mobile computing devices with a mobile operating systems and desktop operating systems running simultaneously and independently on a shared grain without virtualization. The mobile operating system provides a user experience for mobile computing devices that case the mobile environment. The desktop operating system provides a complete desktop user experience when the mobile computing device is docked to a secondary terminal around. Applications in desktop operating systems to communicate with applications and services in the mobile operating system with a framework cross-communication environment. The cross-premises communication structure may include interfaces to the remotable object to allow the process of mobile operating systems and processes in desktop operating systems to share the memory of a thread-safe manner. The mobile computing device may be a smartphone running the Android mobile operating system and a complete desktop Linux distribution on a modified Android kernel.

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System and method for kernel rootkit protection in a hypervisor environment

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The Mcafee, Inc. patent solves the following problem:

In the field of computer network security has become more important and complicated in today's society. about Computer network configured for virtually every business or organization, often with many interconnected computer (for example, the end user computers, laptops, servers, printing devices, etc.). Moreover, the cloud service providers (and other organizations that run multiple applications and operating systems) may use hypervisor technology to run on various different guest operating systems simultaneously on a host device. A hypervisor is a computer software / hardware platform virtualization software that allows multiple operating systems to run on a host computer simultaneously. security threat may come from outside and internally in hypervisor environment. These threats to the hypervisor environment present further challenges for IT administrators.

Our analysis of this patent is as follows:

Mcafee, Inc.’s patent US 9069586 B2 deals with System and method for kernel rootkit protection in a hypervisor environment.
A system and method for protection rootkit in a hypervisor environment includes modules for creating a soft whitelist entries corresponding to each visitor flesh page to a guest operating system in a hypervisor environment, where each entry is a copy of the page to the corresponding page guest flesh, creating a page fault when a process tries to access a page visitor flesh, and teach the process corresponding page article. If the page fault is a data page faults, the method includes hard page faults, and marking a page table entry corresponding to the guest kernel pages as non-executable and writeable. If the page is wrong is a wrong instruction page, the method involves marking a page table entry corresponding to the page flesh guest as read-only. Redirecting changing a page frame number in a shadow page table hypervisor to teach the corresponding duplicate pages.

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Application mirroring using multiple graphics contexts

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The Z124 patent solves the following problem:

This relates generally to the field of mobile environments Computing, and especially to support many user environment through the use of multiple operating systems on a single mobile computing device.

Our analysis of this patent is as follows:

Z124’s patent US 9060006 B2 deals with Application mirroring using multiple graphics contexts.
Cross-around providing support and companionship user to provide a seamless computing experience in a multi-operating system environment Computing. Cross-around naked provides real-time display of the application running on a mobile operating system that is shown in an environment of a desktop operating system. The mobile operating systems and desktop operating system will be running simultaneously and independently on a shared grain on a mobile device Computing. A graphic server mobile operating system in tears and rebuilds the rendering context for each application as it mixed information face. The rendering context can be strengthened to match the resolution of the associated display, so the graphics are rendered appropriate for resolution. The mobile computing device may be a smartphone running the Android mobile operating system and a complete desktop Linux distribution on a modified Android kernel.

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