Compounds

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The Glaxo Group Limited patent solves the following problem:

Syk is a non-receptor tyrosine kinase involved in coupling activated immunoreceptors signal consuming events that mediate diverse cellular responses, including proliferation, distinction, and phagocytosis. Syk is widely expressed in hematopoietic cells. Syk inhibitor with potential anti-inflammatory and immunomodulating activities. They inhibit SYK-mediated IgG Fc epsilon and gamma receptor and BCR receptor signaling, resulting in inhibition of activation of mast cells, macrophages, and B-cells and relevant inflammatory responses and tissue damage. Mast cells play a major role in type I hypersensitivity reactions associated with urticaria, bronchial asthma, anaphylaxis and other allergic conditions. Therefore, SYK inhibitor has attracted interest from a number of therapeutic areas, including the treatment of rheumatoid arthritis, B-cell lymphoma, asthma, rhinitis and cutaneous disorders such as acute and chronic urticaria, mastocytosis, cutaneous lupus , atopic dermatitis, autoimmune bullous conditions including Pemphigus and pemphigoid and other mast cell mediated skin disease.

Our analysis of this patent is as follows:

Glaxo Group Limited’s patent US 9447074 B2 deals with Compounds.
A compound of formula (I): or a salt thereof; which is an inhibitor of spleen tyrosine kinase (SYK) and therefore potential use in the treatment of diseases resulting from inappropriate activation of mast cells, macrophages, and B-cells and related inflammatory responses and tissue damage, for example inflammatory diseases and / or allergic conditions, in cancer therapy, especially heme malignancies, and autoimmune conditions.

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Rear-mounted retractable aerodynamic structure for cargo bodies

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The Stemco Lp patent solves the following problem:

Trucking is the primary means of long-distance and short-haul transportation of goods and materials in the United States, and in many other countries. Trucks often include a motorized cab where the driver sits and working on cars. cab attached to a box-like cargo section. Smaller trucks often include an integrated cargo section sitting in a unified framework which extends from the front wheels to the rear wheel assembly. The larger trucks often includes a detachable cab unit, with many driven axles, and a special trailer with a long box-like cargo units served on two or more phrases assemblies wheels. These trucks assemblages commonly called semi-trailers or tractor trailers. Most modern trucks' cabs, especially for tractor trailers, fitted with aerodynamic fairings on the roof, side and front. These fairings to help direct air over the exposed surface of the box-like cargo body, generally gave higher (a few feet) than the average roof cab. The flat, projecting front face of a cargo body is a strong source of drag on the cab roof. The use of the front-mounted aerodynamic fairings in recent years have served to significantly lower drag and, therefore, raise fuel economy for trucks, especially those traveling at high speed in the open roads.

Our analysis of this patent is as follows:

Stemco Lp’s patent US 9440688 B2 deals with Rear-mounted retractable aerodynamic structure for cargo bodies.
A flying structure attached to the sides and the top of a truck cargo body (even in a stand-alone trailer or a straight truck cab and cargo area as a fixed the car) aftmost region, often involving a rolling door assembly, rolls upwardly. A navigational structure is permanently attached to the sides and on the trailer in a way that extend past the aftmost truck cargo plane body and withdrawal aftmost truck cargo plane body when subjected to a force, allowing the device to be supported by the structure. Redeems orientation allows for the back of the trailer to be fully accessible for loading and unloading, and does not reduce the size of the opening of the trailer. The various embodiments of the invention allows for automated deployment once the force used to compress the structure to be taken.

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Substituted phenyl-Spleen Tyrosine Kinase (Syk) inhibitors

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The Merck Sharp & Dohme Corp., , Merck Canada Inc. patent solves the following problem:

Spleen Tyrosine Kinase (SYK) is a protein tyrosine kinase described as a key mediator of immunoreceptor signaling a host of inflammatory cells including mast cells, B-cells, macrophages and neutrophils. These immunoreceptors, including Fc receptor and the B-cell receptor, is important for allergic diseases, and antibody-mediated autoimmune diseases and thus pharmacologically interfering SYK conceivably treat these diseases.

Our analysis of this patent is as follows:

Merck Sharp & Dohme Corp., , Merck Canada Inc.’s patent US 9353066 B2 deals with Substituted phenyl-Spleen Tyrosine Kinase (Syk) inhibitors.
invention provides certain substituted phenyl compounds of Formula (I) or pharmaceutically acceptable salts thereof, wherein R1, R2, P3, R4, RCY, and t as described here. invention also provides pharmaceutical compositions comprising such compounds, and methods of using the compounds for treating diseases or conditions mediated spleen tyrosine kinase (SYK).

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Polymorphic crystal forms of 5-(2-{[6-(2,2-difluoro-2-phenylethoxy)hexyl]amino}-1-(R)-hydroxyethyl)-8-hydroxyquinolin-2(1H)-one, heminapadisytlate as agonist of the 2 adrenergic receptor

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The Almirall, S.A. patent solves the following problem:

5- (2 – {[6- (2,2-difluoro-2-phenylethoxy) hexyl] amino} -1 (R) -hydroxyethyl) -8-hydroxyquinolin-2 (1H) -one (Compound I) is a valiant 2 adrenoceptor agonist first disclosed in WO 2006/122788. This compound of the following chemical formula.

Our analysis of this patent is as follows:

Almirall, S.A.’s patent US 9346759 B2 deals with Polymorphic crystal forms of 5-(2-{[6-(2,2-difluoro-2-phenylethoxy)hexyl]amino}-1-(R)-hydroxyethyl)-8-hydroxyquinolin-2(1H)-one, heminapadisytlate as agonist of the 2 adrenergic receptor.
The present invention is directed to novel polymorphic crystalline form of a 5- (2 – {[6- (2,2-difluoro-2-phenylethoxy) hexyl] amino} -1- (R) -hydroxyethyl) -8-hydroxyquinolin- 2 (1H) -one, heminapadisylate. invention is also directed to pharmaceutical compositions comprising said polymorphic crystalline forms, ways to use them to treat respiratory diseases associated with 2 adrenergic receptor activity and a process to prepare the polymorphic crystalline forms.

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Self-deploying apparatuses, assemblies, and methods for drag reduction of land vehicles

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The Aerovolution Corporation patent solves the following problem:

The present disclosure relates to drag reduction for land vehicles, such as trucks, tractor-trailer trailer, buses, recreational vehicles and the like. Drag generated by a vehicle shall be proportional to the surface area of ​​the vehicle, and the larger vehicle on earth will be particularly concerned with reducing drag to reduce fuel consumption. While some drag reduction devices for cars on land known, devices of this kind may have limitations and is not suitable for all applications. For example, known drag reduction devices are often designed to attach to the frame of a truck cargo door. Thus, the drag reduction device must be pulled to the side of the truck body and / or opened to access to the cargo door. It can be inconvenient as it may add extra steps by a freight operator reach. This may be especially drawback for cargo or other shipping operators who will operate under the tight schedule. Alternate and / or improved devices for drag reduction would be desirable.

Our analysis of this patent is as follows:

Aerovolution Corporation’s patent US 9333993 B2 deals with Self-deploying apparatuses, assemblies, and methods for drag reduction of land vehicles.
Examples of drag reduction equipment and assemblies for vehicles on land, and especially for attachment to a door of a car in the country operated by a cam lock bar, described. A drag reduction apparatus may include a plurality of panels foldedly became and automatically deployable to a configuration revealed. The panels can be combined with a base panel with the car door on the ground with a double-hinge mechanism actuated cam lock bar. The double-hinge mechanism to draw the base panel to the centerline of the car behind the land to allow the door to fully open the drag reduction apparatus attached. The tools can be attached to two adjacent gates on a land vehicle and a plurality of panels in a door configured to overlap with a plurality of panels in the adjoining door.

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Automatic web service monitoring

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The Domo, Inc. patent solves the following problem:

Our analysis of this patent is as follows:

Domo, Inc.’s patent US 9191285 B1 deals with Automatic web service monitoring.
According to various embodiments, the present invention provides a live site performance monitoring in the context of reasonable resource hierarchies found in cloud computing systems. In particular, in an image, the system of the present invention facilitates monitoring of new services Computing without necessarily requires clear knowledge of these new services. Such services may include, for example and without limitation, given the use of an image that State Transfer (REST) ​​architecture, although the techniques described herein may also be used in other architectures. In one embodiment, the system of the present invention works by automatically creating groups of things for performance monitoring, based on the hierarchy of a type. Heuristics can be used to determine aggregatable hierarchy nodes.

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Cross-environment application compatibility for single mobile computing device

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The Z124 patent solves the following problem:

This relates generally to the field of mobile environments Computing, and especially to support many user environment through the use of multiple operating systems on a single mobile computing device.

Our analysis of this patent is as follows:

Z124’s patent US 9160796 B2 deals with Cross-environment application compatibility for single mobile computing device.
A seamless cross-around workflow given a multi-operating system environment Computing. The multi-operating system computing environments may include a mobile operating system and a desktop operating system running simultaneously and independently on a mobile device Computing. Two or more application programs, running the operating system independent of user interaction with the state information including user data, user settings, and / or application context information. Interaction with the state information may be shared for the applications used primarily to access and edit the user's local content as well as applications that communicate with a remote server or access and navigate other remote content ( for example, Internet-based application, browser, etc.). The mobile computing device may be a smartphone running the Android mobile operating system and a complete desktop Linux distribution on a modified Android kernel.

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Determining usefulness of a data alert

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The Domo, Inc. patent solves the following problem:

Our analysis of this patent is as follows:

Domo, Inc.’s patent US 9082282 B1 deals with Determining usefulness of a data alert.
An alert to provide a user notification when a cause that situation regarding the operation of a business that satisfied. Before making the alert, a proposed trigger alert conditions can be received. The trigger conditions can be compared to a database of operational data related to business operations over a period of time to obtain the historical data purposes. The historical data in the vise may indicate how the proposed alert would work if applied to the operational data for the period of time, for example, by showing how the many times the alert may be triggered during the period of the season. The historical data in the vise can be given to a user, and facilitate user determination if the proposed alert will perform as intended. Once the desired proposed alert entered, user can put the proposed alert as a real alert.

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Devices and methods for reducing vehicle drag

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The Smarttruck Systems, Llc patent solves the following problem:

An ongoing effort to reduce the drag in vehicular structures is of great importance as the fuel economy will be a greater consideration in vehicular design. As the drag of a car increases, the amount of fuel needed to move vehicles also increased because of greater energy required to overcome drag. For example, it states that for a vehicle traveling at 70 mph, 65% of the total fuel consumption of the engine of the car used to overcome drag. Therefore, even a small reduction in drag experienced by a vehicle traveling at a speed of course would result in a significant improvement in fuel economy.

Our analysis of this patent is as follows:

Smarttruck Systems, Llc’s patent US 9056636 B2 deals with Devices and methods for reducing vehicle drag.
In some embodiments of the present invention, a vehicle trailer is described which includes a shelf component that extends from the side wall of the trailer and that describes a sloped surface.

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Flame retardant polymer compositions

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The Sabic Global Technologies B.V. patent solves the following problem:

Crosslinked polyamide compositions known in the art (See, W. Feng et al., Radiation Physics and Chemistry, 63, pp. 493-496 (2002)). Japanese published application 59-012936A2 describes a crosslinked polyamide resins that obtained by exposing a polyamide resin containing a crosslinker of a radiation beam. resin will be free glass fiber, and a flame retardant or filler can be incorporated into the resin.

Our analysis of this patent is as follows:

Sabic Global Technologies B.V.’s patent US 9006306 B2 deals with Flame retardant polymer compositions.
On the one hand, the invention relates to cross-linking, the flame retardant polymer composition which comprises a polyamide or polyester; a flame retardant system; a crosslinking agent; and a flame retardant coagent system. abstract It is intended as a scanning tool for purposes of searching in the particular art and is not intended to limit the present invention.

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