BTK inhibitors

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The Merck Sharp & Dohme Corp. patent solves the following problem:

B lymphocyte activation is key to the generation of adaptive immune responses. Derailed B lymphocyte activation is a sign of many autoimmune diseases and in the modulation of the immune response and therapeutic interest. Recently the success of B cell therapy in autoimmune disease is established. Treatment of rheumatoid arthritis (RA) patients with Rituximab (anti-CD20 therapy) is an accepted clinical therapy today. More recent clinical trial studies showed that treatment with Rituximab also ameliorates symptoms of the disease in relapsing remitting multiple sclerosis (RRMS) and systemic lupus erythematosus (murder) patients. This success supports the potential for future therapies for autoimmune diseases targeted B cell immunity.

Our analysis of this patent is as follows:

Merck Sharp & Dohme Corp.’s patent US 9446130 B2 deals with BTK inhibitors.
The present invention provides Bruton's tyrosine kinase (Btk) inhibitor compounds according to Formula I or pharmaceutically acceptable salt thereof. Formula I or a pharmaceutically acceptable salt thereof or pharmaceutical compositions comprising these compounds and their use in therapy. In particular, the present invention relates to the use of Btk inhibitor compounds for the treatment of Btk mediated disorder.

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Aerodynamic structures secured to the underbody of cargo bodies

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The Stemco Lp patent solves the following problem:

Trucking is the primary means of long-distance and short-haul transportation of goods and materials in the United States, and in many other countries. Trucks often include a motorized cab where the driver sits and working on cars. cab attached to a box-like cargo section. Smaller trucks often include an integrated cargo section sitting in a unified framework which extends from the front wheels to the rear wheel assembly. The larger trucks often includes a detachable cab unit, with many driven axles, and a special trailer with a long box-like cargo units served on two or more phrases assemblies wheels. These trucks assemblages commonly called semi-trailers or tractor trailers. Most modern trucks' cabs, especially for tractor trailers, fitted with aerodynamic fairings on the roof, side and front. These fairings to help direct air over the exposed surface of the box-like cargo body, generally gave higher (a few feet) than the average roof cab. The flat, projecting front face of a cargo body is a strong source of drag on the cab roof. The use of the front-mounted aerodynamic fairings in recent years have served to significantly lower drag and, therefore, raise fuel economy for trucks, especially those traveling at high speed in the open roads.

Our analysis of this patent is as follows:

Stemco Lp’s patent US 9440689 B1 deals with Aerodynamic structures secured to the underbody of cargo bodies.
A flight underbody fairing or skirt that is attached to the rear wheels or bogeys in a cargo truck bodies generally can be slidably adjusted fore and aft along the cargo body. The various embodiments allow for a skirt that attaches bogeys in a cargo truck body and given back to the plane behind the trailer, and a retractable nature to allow for slidable change bogeys fore and aft along the cargo body for the purpose of continuing streamlined flow along the side of a cargo truck body equipped with a side of the border before the bogeys. In various embodiments of the invention, the retractable nature of the invention allows for a continuous edge surface of the plane with the side of the truck cargo bodies came from the back bogeys truck cargo plane body, without attention bogey position.

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Substituted pyridine spleen tyrosine kinase (SYK) inhibitors

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The Merck Sharp & Dohme Corp., , Merck Canada Inc. patent solves the following problem:

Spleen Tyrosine Kinase (SYK) is a protein tyrosine kinase described as a key mediator of immunoreceptor signaling a host of inflammatory cells including mast cells, B-cells, macrophages and neutrophils. These immunoreceptors, including Fc receptor and the B-cell receptor, is important for allergic diseases, and antibody-mediated autoimmune diseases and thus pharmacologically interfering SYK conceivably treat these diseases.

Our analysis of this patent is as follows:

Merck Sharp & Dohme Corp., , Merck Canada Inc.’s patent US 9376418 B2 deals with Substituted pyridine spleen tyrosine kinase (SYK) inhibitors.
invention provides certain substituted Pyridines of Formula (I) or pharmaceutically acceptable salts thereof, wherein R1, R2, P3, R4, rcy, CY, and t as described here. invention also provides pharmaceutical compositions comprising such compounds, and methods of using the compounds for treating diseases or conditions mediated spleen tyrosine kinase (SYK) kinase.

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Processes for making lactose utilizing pre-classification techniques and pharmaceutical formulations formed therefrom

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The Dmv-Fonterra Excipients Technology Gmbh, , Glaxo Group Limited patent solves the following problem:

In the field of inhalation therapy, it is generally desirable to use therapeutic molecules having a particle size (ie, diameter) in the range of 1 to 10 m. carrier molecule or excipients, such as lactose, canine therapeutic preparation also includes significantly larger diameter particles (for example, 100 to 150 m) which are not normally penetrate into the upper respiratory tract to the same degree as the active ingredient. In general, it is better to use a smaller particle size for the lactose or a lactose blend having a defined ratio of coarse and fine lactose.

Our analysis of this patent is as follows:

Dmv-Fonterra Excipients Technology Gmbh, , Glaxo Group Limited’s patent US 9365905 B2 deals with Processes for making lactose utilizing pre-classification techniques and pharmaceutical formulations formed therefrom.
A process for forming lactose suitable for use in a pharmaceutical formulation comprises providing a plurality of lactose particles containing no more than 10% w / w of lactose particles with a number average the particle size of about 70 microns or less; stands the plurality of lactose particles to yield a plurality of milled lactose particles with an average particle size, (D50), from 50 micron to 100 micron; and classifying the plurality of milled lactose particles at least two pieces consisting of a fine particle and a coarse particle in which the fine particle has an average particle size, (D50), from 3 microns to 50 microns, and the coarse particle has an average particle size, (D50), from 40 micron to 250 micron.

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Substituted phenyl-Spleen Tyrosine Kinase (Syk) inhibitors

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The Merck Sharp & Dohme Corp., , Merck Canada Inc. patent solves the following problem:

Spleen Tyrosine Kinase (SYK) is a protein tyrosine kinase described as a key mediator of immunoreceptor signaling a host of inflammatory cells including mast cells, B-cells, macrophages and neutrophils. These immunoreceptors, including Fc receptor and the B-cell receptor, is important for allergic diseases, and antibody-mediated autoimmune diseases and thus pharmacologically interfering SYK conceivably treat these diseases.

Our analysis of this patent is as follows:

Merck Sharp & Dohme Corp., , Merck Canada Inc.’s patent US 9353066 B2 deals with Substituted phenyl-Spleen Tyrosine Kinase (Syk) inhibitors.
invention provides certain substituted phenyl compounds of Formula (I) or pharmaceutically acceptable salts thereof, wherein R1, R2, P3, R4, RCY, and t as described here. invention also provides pharmaceutical compositions comprising such compounds, and methods of using the compounds for treating diseases or conditions mediated spleen tyrosine kinase (SYK).

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Adjustable side under-ride guard for sliding axle trailer

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The Stephen Allen Batzer, , Patrick Keith Rogers patent solves the following problem:

The recognized hazard of side collision against dragged trailers traced at least back in 1938 that Robinson invented a peripheral guard for a hook-mounted trailer. See US Pat. No. 2,002,832. In his patent teaches a fixed whole periphery kept for a towed trailer with fixed rear axle. This non-regulated system to guard against the impact on the trailer from all directions.

Our analysis of this patent is as follows:

Stephen Allen Batzer, , Patrick Keith Rogers’s patent US 9352714 B2 deals with Adjustable side under-ride guard for sliding axle trailer.
A side under-ride collision guard described configured sitting in a large trailer equipped with a sliding rear axle, consisting of one or more energy absorbing structures cut wood axially adjustable for the position included in a multiplicity of similar barriers to diminish the impact hazard to other users paths presented lower axial edge (s) in the cargo compartment of the region (s) among the back the wheels of the trailer and the trailer back under-ride guard and / or between a stationary side under-ride guard and publicly trailer's wheels.

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Neurogenesis screening method and uses thereof

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The Mead Johnson Nutrition Company patent solves the following problem:

The brain has only 2% of the total weight of the body, but it is a difficult organ used in 30% of calories in the day and nutrients. (Harris, JJ et al, The Energetics of CNS White Matter jour Neuroscience, January 2012: 32 (1): 356-371). The human brain and nervous system begin construction early in prenatal life and the two continue to develop until the age of three. This early development may have lifelong effects on overall brain and nervous system health. Therefore, brain nutrients become important additives in the diet of infants, children and pregnant and lactating women because of their ability to improve early brain development and the prevention and protection from brain and nervous system injury or illness. Moreover, brain nutrition is important for adults, as many nutrients to the developing nervous system to repair and provide neuroprotective benefits to health.

Our analysis of this patent is as follows:

Mead Johnson Nutrition Company’s patent US 9351978 B2 deals with Neurogenesis screening method and uses thereof.
If there are methods for detecting and / or evidence of neurogenesis effect on cholesterol and / or oxysterol using adipose-derived stem cells (ADSCs). Also given are the ways to promote neurogenesis in ADSCs. It also gives the approach to the use of cholesterol and / or production oxysterol for a neurologic component to be incorporated into a nutritional composition for increasing neurogenesis in a pediatric subject.

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Aerodynamic drag reducing apparatus

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The Stemco Lp patent solves the following problem:

It is known that a significant amount of aerodynamic drag created when a car traveling at velocities typical in a modern way. This is due, in large part, to areas of low pressure prompting the back of the car. The lower the pressure becomes more pronounced as airflow over the vehicle separates from the surfaces vehicles. The event airflow separation also well known in aircraft wing design and, in this case, cause the wing stop.

Our analysis of this patent is as follows:

Stemco Lp’s patent US 9346496 B2 deals with Aerodynamic drag reducing apparatus.
A flight drag reducing apparatus for use in vehicles with lower surfaces that are not streamlined. facilities include folding panels that extend rearward for use in a drag reducing configuration and crushed for use in a space saving configuration.

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Self-deploying apparatuses, assemblies, and methods for drag reduction of land vehicles

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The Aerovolution Corporation patent solves the following problem:

The present disclosure relates to drag reduction for land vehicles, such as trucks, tractor-trailer trailer, buses, recreational vehicles and the like. Drag generated by a vehicle shall be proportional to the surface area of ​​the vehicle, and the larger vehicle on earth will be particularly concerned with reducing drag to reduce fuel consumption. While some drag reduction devices for cars on land known, devices of this kind may have limitations and is not suitable for all applications. For example, known drag reduction devices are often designed to attach to the frame of a truck cargo door. Thus, the drag reduction device must be pulled to the side of the truck body and / or opened to access to the cargo door. It can be inconvenient as it may add extra steps by a freight operator reach. This may be especially drawback for cargo or other shipping operators who will operate under the tight schedule. Alternate and / or improved devices for drag reduction would be desirable.

Our analysis of this patent is as follows:

Aerovolution Corporation’s patent US 9333993 B2 deals with Self-deploying apparatuses, assemblies, and methods for drag reduction of land vehicles.
Examples of drag reduction equipment and assemblies for vehicles on land, and especially for attachment to a door of a car in the country operated by a cam lock bar, described. A drag reduction apparatus may include a plurality of panels foldedly became and automatically deployable to a configuration revealed. The panels can be combined with a base panel with the car door on the ground with a double-hinge mechanism actuated cam lock bar. The double-hinge mechanism to draw the base panel to the centerline of the car behind the land to allow the door to fully open the drag reduction apparatus attached. The tools can be attached to two adjacent gates on a land vehicle and a plurality of panels in a door configured to overlap with a plurality of panels in the adjoining door.

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Nutritional compositions with lipid globules with a core comprising vegetable lipids and a coating comprising phospholipids or polar lipids

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The N.V. Nutricia patent solves the following problem:

Breast-feeding is the preferred method of infant feeding. However, there are circumstances that make breast-feeding impossible or less attractive. In the case of children's formula is a good alternative. The composition of modern infant formulas is adapted in such a way that will meet many of the special nutritional needs of the fast growing and developing infant.

Our analysis of this patent is as follows:

N.V. Nutricia’s patent US 9320294 B2 deals with Nutritional compositions with lipid globules with a core comprising vegetable lipids and a coating comprising phospholipids or polar lipids.
The present invention relates to a nutritional composition for children and / or children consisting of a lipid component that has a large volume lipid globule. composition can be used to prevent obesity and / or improve body composition later in life. Said lipid component comprises 10-50 wt% vegetable lipid, and the lipid globules with a number-laden diameter up to 1.0 m and / or a diameter of 2-12 m in an amount of at least 45 vol%.

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