Aerodynamic drag reducing apparatus

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The Stemco Lp patent solves the following problem:

It is known that a significant amount of aerodynamic drag created when a car traveling at velocities typical in a modern way. This is due, in large part, to areas of low pressure prompting the back of the car. The lower the pressure becomes more pronounced as airflow over the vehicle separates from the surfaces vehicles. The event airflow separation also well known in aircraft wing design and, in this case, cause the wing stop.

Our analysis of this patent is as follows:

Stemco Lp’s patent US 9346496 B2 deals with Aerodynamic drag reducing apparatus.
A flight drag reducing apparatus for use in vehicles with lower surfaces that are not streamlined. facilities include folding panels that extend rearward for use in a drag reducing configuration and crushed for use in a space saving configuration.

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Bipyridylaminopyridines as Syk inhibitors

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The Merck Sharp & Dohme Corp., , Merck Canada Inc. patent solves the following problem:

Spleen Tyrosine Kinase (SYK) is a protein tyrosine kinase described as a key mediator of immunoreceptor signaling a host of inflammatory cells including mast cells, B-cells, macrophages and neutrophils. These immunoreceptors, including Fc receptor and the B-cell receptor, is important for allergic diseases, and antibody-mediated autoimmune diseases and thus pharmacologically interfering SYK conceivably treat these diseases.

Our analysis of this patent is as follows:

Merck Sharp & Dohme Corp., , Merck Canada Inc.’s patent US 9145391 B2 deals with Bipyridylaminopyridines as Syk inhibitors.
The present invention provides new pyrimidine amines of formula I are potent inhibitor of spleen tyrosine kinase, or prodrugs thereof, and useful in the treatment and prevention of diseases mediated by said enzyme, such as asthma, COPD and rheumatoid arthritis and cancer.

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Non-digestible oligosaccharides for oral induction of tolerance against dietary proteins

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The N.V. Nutricia patent solves the following problem:

During the common process of nutrition in food proteins presented to the immune system through the gastro-intestinal tract without an immune response to ingested nutrients. This unresponsiveness is called oral immune tolerance or oral tolerance. The induction of oral immune tolerance is especially relevant for children, after being exposed for the first time to eat protein and adapt to it. If the children's oral immune tolerance is established, food allergies occur. The people who suffer from food allergies requires a specific food protein food to avoid.

Our analysis of this patent is as follows:

N.V. Nutricia’s patent US 9119838 B2 deals with Non-digestible oligosaccharides for oral induction of tolerance against dietary proteins.
Composition and the manner in which the child nutrition partially hydrolysed protein and non-digestible oligosaccharides for use in the induction of oral tolerance against the native of dietary protein.

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Flow in reinforced polyimide compositions

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The Sabic Global Technologies B.V. patent solves the following problem:

Polyimides (PI), and in particular polyetherimides (PEI), are high performance polymers with a glass transition temperature (GK) to greater than 180 C. These polymers have added height strength, heat resistance, and modulus, and broad chemical resistance. Polyetherimides widely used in applications as diverse as automotive, telecommunication, aerospace, electrical / electronics, transportation, and healthcare. In addition to a filler helps provide materials particularly useful as the molten metal portion in place, for example in the automotive and electrical / electronic applications from these compositions offer good mechanical and thermal properties.

Our analysis of this patent is as follows:

Sabic Global Technologies B.V.’s patent US 8784719 B2 deals with Flow in reinforced polyimide compositions.
Reinforced polyimide composition containing a filler and a polyamide flow promoter to improve the flow promotion while the other mechanical, heat, flame and / or electrical properties of the composition. The composition may include an inorganic or organic filler, a polyimide resin such as polyetherimide or polyamideimide and a small amount of an aromatic or aliphatic polyamide as promoter flow. The resulting composition can be used in thinner wall applications while still remaining useful physical properties of reinforced polyimide composition flow promoter. abstract It is intended as a scanning tool for purposes of searching in the particular art and is not intended to limit the present invention.

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Compositions comprising signal peptide-containing proteins

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The Incyte Corporation patent solves the following problem:

Protein transport is essential for cellular function. Transport in a protein may be mediated by a peptide signal located at the amino terminal protein itself. The signal peptide consists of ten to twenty hydrophobic amino acids that target the nascent protein from ribosome to a particular membrane bound compartment such as the endoplasmic reticulum (ER). Protein target the ER to continue by way secretory or stay in any of the secretory organelles such as the ER, Golgi apparatus, or lysosomes. Proteins that transit through the secretory way be secreted into the extracellular space or left in the plasma membrane. Secreted proteins are often synthesized as inactive precursors because of the post-translation processing events during transit through the secretory way. Such events include glycosylation, phosphorylation, proteolysis, and removal of the signal peptide with a signal peptidase. The other events that occur during the transport proteins include chaperone-dependent expression and folding of nascent proteins and protein interaction with a receptor or pore complex. Examples of secreted proteins with amino terminal signal peptide described below and include the receptor, extracellular matrix molecules, cytokines, hormones, growth and diversity factor, neuropeptides, vasomediators, phosphokinases, phosphatases, phospholipases, phosphodiesterases, G and Ras-related protein, Ion channels, pedagogue / pump, proteases, and transcription factors. (Reviewed in Alberts, B. et al. (1994) Molecular Biology of the Cell, garland Publishing, New York, NY, pp. 557-560, 582-592.)

Our analysis of this patent is as follows:

Incyte Corporation’s patent US 8716445 B2 deals with Compositions comprising signal peptide-containing proteins.
human invention provides signal peptide-containing proteins (HSPP) and polynucleotides which identify and encode HSPP. invention also provides expression vector, host cells, antibodies, agonists and antagonists. invention also provides methods for diagnosing, treating, or preventing diseases associated with expression of HSPP.

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Substance communicating device with activatable connector and cycle structure

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The Whirlpool Corporation patent solves the following problem:

Appliances and other useful household equipment designed to interact with one another, as well as with a variety of consumer accessory devices. A consumer accessory device can be used, for example, with an appliance to improve or increase the functionality of the appliance.

Our analysis of this patent is as follows:

Whirlpool Corporation’s patent US 8700809 B2 deals with Substance communicating device with activatable connector and cycle structure.
A wealth of communication device for use with a device or a system including an appliance and a wealth of communication devices. The substance of the communication device with a service connector component operably engageable with a service connector component on the appliance to allow communication with a wealth between the appliance and the rich communication devices. Information related to the substance can be expressed in the appliance and used to affect the physical cycle of appliance operation.

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Human -adrenergic receptor kinase polypeptide and methods

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The Incyte Corporation patent solves the following problem:

Change protein phosphorylation is ubiquitous methods used to control many of intracellular events in eukaryotic cells. It is estimated that more than ten percent of the active protein in a typical mammal cell are phosphorylated. Kinases to facilitate the transfer of high-energy phosphate group from adenosine triphosphate (ATP) to the target protein hydroxyamino acid residues serine, threonine, or tyrosine. Phosphatases, in contrast, take the phosphate groups. Extracellular signal including hormone; neurotransmitter, growth and inequality factors may activate kinases, which takes place as the cell surface of cells or as activator in the final effector proteins, as well as other places along the way signal transduction. Cascade of kinases occur, as well as sensitive kinases second messenger molecules. This system allows for equipment to amplify the weak signal (lower abundance of growth factor molecules, for example), as well as the synthesis of many weak signal into an all-or-nothing answer. Phosphatases, then, is necessary to determine the extent of phosphorylation in cells and, with kinases, controlling key cellular processes such as metabolic enzyme activity, proliferation, cell growth and inequality, cell adhesion, and cell cycle progression.

Our analysis of this patent is as follows:

Incyte Corporation’s patent US 8263378 B2 deals with Human -adrenergic receptor kinase polypeptide and methods.
Various embodiments of the invention provide human kinases and phosphatases (KPP) polypeptides and polynucleotides which identify and encode KPP. Embodiments of the invention also giving expression vector, host cells, antibodies, agonists and antagonists. Some embodiments provide methods for diagnosing, treating, or preventing diseases associated with aberrant expression of KPP.

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Compositions comprising oligosaccharides

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The Nestec S.A. patent solves the following problem:

Our analysis of this patent is as follows:

Nestec S.A.’s patent US 7842678 B2 deals with Compositions comprising oligosaccharides.
The present invention concerns compositions comprising a saccharide for inhibition of pathogen adhesion to mammalian cells.

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Nutrition bar and process of making components

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The Slim-Fast Foods Company, Division Of Conopco, Inc. patent solves the following problem:

Increasingly, a focus of modern preventive medicine is the reduced weight. Excess weight often quoted in reports about the proliferation of cases of type 2 diabetes. Furthermore, obesity is often mentioned in discussions of other modern diseases, such as heart disease.

Our analysis of this patent is as follows:

Slim-Fast Foods Company, Division Of Conopco, Inc.’s patent US 7220442 B2 deals with Nutrition bar and process of making components.
A nutrition bar that contains protein in the form of pellets with high levels of selected proteins. Using all the gold to produce, nutrition bars are formulated with high levels of protein, but good taste and other organoleptic properties. The entire gold according to the invention includes more than 50 wt% of a non-soy protein selected from the group consisting of milk protein, rice protein and pea proteins, especially between 51 wt% and 99 wt %, more preferably between 52 wt% and 95 wt%, more preferably 55 wt% or over. The milk protein is the best whey protein. The whole creation of the best made using an extrusion process wherein the extrusion temperature was initiated to avoid damage to whey protein and symmetrical in flavor. In this process according to the invention, extrusion is conducted at temperatures from 60 to 140 C., after which the protein was dried using a belt / conveyor drier or a fluid bed drier. In another way to make the gel according to the invention, a low extrusion temperature of 90 C. employed one or more supercritical fluids injected by extrusion to form a puffed product.

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Proteases

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The Incyte Corporation patent solves the following problem:

Proteases cleave proteins and peptides in the peptide bond which forms the backbone of the protein or peptide chain. Proteolysis is one of the most important and often enzymatic reactions that occur both inside and outside the cells. Proteolysis is responsible for the activation and maturation of growing polypeptides, the degradation of misfolded and damaged proteins, and the controlled turnover of the peptide within the cell. Proteases involved in digestion, endocrine function, and tissue remodeling during embryonic development, wound healing and normal growth. Proteases play a role in the regulatory process by affecting half the life of the regulatory protein. Proteases involved in the etiology or progression of diseases such as inflammation, angiogenesis, tumor scattering and metastasis, cardiovascular disease, neurological disease, and the bacteria, parasitic, and viral infections.

Our analysis of this patent is as follows:

Incyte Corporation’s patent US 6927056 B2 deals with Proteases.
invention provides in one cysteine ​​proteases and polynucleotides that encode proteases. invention also provides expression vector, host cells, antibodies, agonists and antagonists, as well as methods for diagnosing, treating, or preventing diseases associated with aberrant expression of cysteine ​​proteases.

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