Substituted phenyl-Spleen Tyrosine Kinase (Syk) inhibitors

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The Merck Sharp & Dohme Corp., , Merck Canada Inc. patent solves the following problem:

Spleen Tyrosine Kinase (SYK) is a protein tyrosine kinase described as a key mediator of immunoreceptor signaling a host of inflammatory cells including mast cells, B-cells, macrophages and neutrophils. These immunoreceptors, including Fc receptor and the B-cell receptor, is important for allergic diseases, and antibody-mediated autoimmune diseases and thus pharmacologically interfering SYK conceivably treat these diseases.

Our analysis of this patent is as follows:

Merck Sharp & Dohme Corp., , Merck Canada Inc.’s patent US 9353066 B2 deals with Substituted phenyl-Spleen Tyrosine Kinase (Syk) inhibitors.
invention provides certain substituted phenyl compounds of Formula (I) or pharmaceutically acceptable salts thereof, wherein R1, R2, P3, R4, RCY, and t as described here. invention also provides pharmaceutical compositions comprising such compounds, and methods of using the compounds for treating diseases or conditions mediated spleen tyrosine kinase (SYK).

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Polymorphic crystal forms of 5-(2-{[6-(2,2-difluoro-2-phenylethoxy)hexyl]amino}-1-(R)-hydroxyethyl)-8-hydroxyquinolin-2(1H)-one, heminapadisytlate as agonist of the 2 adrenergic receptor

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The Almirall, S.A. patent solves the following problem:

5- (2 – {[6- (2,2-difluoro-2-phenylethoxy) hexyl] amino} -1 (R) -hydroxyethyl) -8-hydroxyquinolin-2 (1H) -one (Compound I) is a valiant 2 adrenoceptor agonist first disclosed in WO 2006/122788. This compound of the following chemical formula.

Our analysis of this patent is as follows:

Almirall, S.A.’s patent US 9346759 B2 deals with Polymorphic crystal forms of 5-(2-{[6-(2,2-difluoro-2-phenylethoxy)hexyl]amino}-1-(R)-hydroxyethyl)-8-hydroxyquinolin-2(1H)-one, heminapadisytlate as agonist of the 2 adrenergic receptor.
The present invention is directed to novel polymorphic crystalline form of a 5- (2 – {[6- (2,2-difluoro-2-phenylethoxy) hexyl] amino} -1- (R) -hydroxyethyl) -8-hydroxyquinolin- 2 (1H) -one, heminapadisylate. invention is also directed to pharmaceutical compositions comprising said polymorphic crystalline forms, ways to use them to treat respiratory diseases associated with 2 adrenergic receptor activity and a process to prepare the polymorphic crystalline forms.

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Nutritional compositions with lipid globules with a core comprising vegetable lipids and a coating comprising phospholipids or polar lipids

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The N.V. Nutricia patent solves the following problem:

Breast-feeding is the preferred method of infant feeding. However, there are circumstances that make breast-feeding impossible or less attractive. In the case of children's formula is a good alternative. The composition of modern infant formulas is adapted in such a way that will meet many of the special nutritional needs of the fast growing and developing infant.

Our analysis of this patent is as follows:

N.V. Nutricia’s patent US 9320294 B2 deals with Nutritional compositions with lipid globules with a core comprising vegetable lipids and a coating comprising phospholipids or polar lipids.
The present invention relates to a nutritional composition for children and / or children consisting of a lipid component that has a large volume lipid globule. composition can be used to prevent obesity and / or improve body composition later in life. Said lipid component comprises 10-50 wt% vegetable lipid, and the lipid globules with a number-laden diameter up to 1.0 m and / or a diameter of 2-12 m in an amount of at least 45 vol%.

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Method for initiating a consumable-based cycle of operation

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The Whirlpool Corportion patent solves the following problem:

The invention relates to the use of consumables through a communication device on a network creatures, and especially, the choice of appliance from a plurality of appliances that have an event associated with consumable.

Our analysis of this patent is as follows:

Whirlpool Corportion’s patent US 9277188 B2 deals with Method for initiating a consumable-based cycle of operation.
One way to start a cycle of operation based on a consumable includes providing a consumable reader with a software architecture configured to image data, talk on the one network, and recognition functionalities of appliances based on a unique identification associated with each time a functionality, imaging data of the consumable use consumable reader; Taking cycle data associated with the consumable based on imaged data; know, the software architecture in at least one activity associated with the data cycle; selecting from the plurality of appliances is an appliance with at least one activity using the unique identifier associated with a time of at least one event; and communicating the data cycle to the selected appliance on the network the appliances where the selected appliance becomes a cycle of operation associated with the consumable usage data cycle.

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2-Pyridyl carboxamide-containing spleen tyrosine kinase (SYK) inhibitors

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The Merck Sharp & Dohme Corp. patent solves the following problem:

Spleen Tyrosine Kinase (SYK) is a protein tyrosine kinase described as a key mediator of immunoreceptor signaling a host of inflammatory cells including mast cells, B-cells, macrophages and neutrophils. These immunoreceptors, including Fc receptor and the B-cell receptor, is important for allergic diseases, and antibody-mediated autoimmune diseases and thus pharmacologically interfering SYK conceivably treat these diseases.

Our analysis of this patent is as follows:

Merck Sharp & Dohme Corp.’s patent US 9216173 B2 deals with 2-Pyridyl carboxamide-containing spleen tyrosine kinase (SYK) inhibitors.
invention provides certain 2-pyridyl formamide-containing compounds of Formula (I) or pharmaceutically acceptable salts thereof, wherein A and B as described here. invention also provides pharmaceutical compositions comprising such compounds, and methods of using the compounds for treating diseases or conditions mediated spleen tyrosine kinase (SYK) kinase.

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Policy update apparatus, policy management system, policy update method, policy management method and recording medium

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The Nec Corporation patent solves the following problem:

Technology manager at a software policy that making the information into one resource is known.

Our analysis of this patent is as follows:

Nec Corporation’s patent US 9183009 B2 deals with Policy update apparatus, policy management system, policy update method, policy management method and recording medium.
The present invention provides a policy update tool to update a policy right software configuration changes equivalent to a resource. The update policy tools including policy acquisition means receives a sign resource, read an installation destination resource sign corresponding to the sign of the resources from the resource management means that by providing a mapping between signs that resources and resource-installed destinations characterizing an installation destination resource resource resource recognized the signs installed, and read the policy software corresponding to the signs and resources to install destination resource identification, and policy updates means that software update policy, gather and compare the updated software resource policy signs and install the sign destination resources, and food storage policy through.

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Pyridyl aminopyridines as Syk inhibitors

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The Merck Sharp & Dohme Corp. patent solves the following problem:

Spleen Tyrosine Kinase (SYK) is a protein tyrosine kinase described as a key mediator of immunoreceptor signaling a host of inflammatory cells including mast cells, B-cells, macrophages and neutrophils. These immunoreceptors, including Fc receptor and the B-cell receptor, is important for allergic diseases, and antibody-mediated autoimmune diseases and thus pharmacologically interfering SYK conceivably treat these diseases.

Our analysis of this patent is as follows:

Merck Sharp & Dohme Corp.’s patent US 9120785 B2 deals with Pyridyl aminopyridines as Syk inhibitors.
The present invention provides new pyrimidine amines of formula I are potent inhibitor of spleen tyrosine kinase, and is useful in the treatment and prevention of diseases mediated by said enzyme, such as asthma, COPD, rheumatoid arthritis, and cancer .

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Cross-environment communication framework

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The Z124 patent solves the following problem:

This relates generally to the field of mobile environments Computing, and especially to support many user environment through the use of multiple operating systems on a single mobile computing device.

Our analysis of this patent is as follows:

Z124’s patent US 9098437 B2 deals with Cross-environment communication framework.
A mobile computing devices with a mobile operating systems and desktop operating systems running simultaneously and independently on a shared grain without virtualization. The mobile operating system provides a user experience for mobile computing devices that case the mobile environment. The desktop operating system provides a complete desktop user experience when the mobile computing device is docked to a secondary terminal around. Applications in desktop operating systems to communicate with applications and services in the mobile operating system with a framework cross-communication environment. The cross-premises communication structure may include interfaces to the remotable object to allow the process of mobile operating systems and processes in desktop operating systems to share the memory of a thread-safe manner. The mobile computing device may be a smartphone running the Android mobile operating system and a complete desktop Linux distribution on a modified Android kernel.

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3-pyridyl carboxamide-containing spleen tyrosine kinase (SYK) inhibitors

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The Merck Sharp & Dohme Corp. patent solves the following problem:

Spleen Tyrosine Kinase (SYK) is a protein tyrosine kinase described as a key mediator of immunoreceptor signaling a host of inflammatory cells including mast cells, B-cells, macrophages and neutrophils. These immunoreceptors, including Fc receptor and the B-cell receptor, is important for allergic diseases, and antibody-mediated autoimmune diseases and thus pharmacologically interfering SYK conceivably treat these diseases.

Our analysis of this patent is as follows:

Merck Sharp & Dohme Corp.’s patent US 8987456 B2 deals with 3-pyridyl carboxamide-containing spleen tyrosine kinase (SYK) inhibitors.
invention provides certain 3-pyridyl formamide-containing compounds of Formula (I) (I) or pharmaceutically acceptable salts thereof, wherein A and B as described here. invention also provides pharmaceutical compositions comprising such compounds, and methods of using the compounds for treating diseases or conditions mediated spleen tyrosine kinase (SYK) kinase.

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Tunable resonant leaky-mode N/MEMS elements and uses in optical devices

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The University Of Connecticut patent solves the following problem:

The present invention generally relates to a strategic new field Optical devices based on sound dripped through each modulated films. Particularly, the present invention relates to tunable optical devices based on known nano / micro-electromechanical (N / MEMS) actuation methods, and the practical application thereof.

Our analysis of this patent is as follows:

University Of Connecticut’s patent US 8938141 B2 deals with Tunable resonant leaky-mode N/MEMS elements and uses in optical devices.
Mechanically tunable electromagnetic and photonic devices showed enhanced spectral tunability with minimal mechanical activity given. These nano / micro-electromechanically (N / MEMS) tunable elements, including filtering and pixels, rely on drop-mode resonance effect of subwavelength photonic lattices containing each wavelength. These elements act in reflection (bandstop) or transmission (bandpass) method, and can be arranged in one-dimensional or two-dimensional arrays, or moved as single units, and their spectral region controlled design elements. Input electromagnetic radiation illuminates the elements and then filtered, modulated, or listened analysis by the elements. Mechanical motion to change the structural balance, and therefore, the properties do, the nanostructured elements subwavelength resonance. Furthermore, the use of metals and dielectrics to produce live together plasmonic and drop-mode resonance effect adds to the versatility of potential applications.

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