Aminopyrimidines as Syk inhibitors

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The Merck Sharp & Dohme Corp. patent solves the following problem:

Spleen Tyrosine Kinase (SYK) is a protein tyrosine kinase described as a key mediator of immunoreceptor signaling a host of inflammatory cells including mast cells, B-cells, macrophages and neutrophils. These immunoreceptors, including Fc receptor and the B-cell receptor, is important for allergic diseases, and antibody-mediated autoimmune diseases and thus, pharmacologically interfering with SYK conceivably treat these diseases.

Our analysis of this patent is as follows:

Merck Sharp & Dohme Corp.’s patent US 9290490 B2 deals with Aminopyrimidines as Syk inhibitors.
The present invention provides new pyrimidine amines of formula I are potent inhibitor of spleen tyrosine kinase, and is useful in the treatment and prevention of diseases mediated by said enzyme, such as asthma, COPD, rheumatoid arthritis and cancer.

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Portrait dual display and landscape dual display

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The Z124 patent solves the following problem:

A substantial number of handheld devices Computing, such as cellular phones, tablets, and E-Readers, make use of a touch screen display will not only save the display information to the user, but also to take inputs from the user's command interface. While touch screen display can increase the configurability of the handheld device and to provide a wide variety of user interface options, this flexibility often comes at a price. The two use the touch screen to provide for and receive user commands, while flexible for the user, in order to obfuscate the display, and cause visual clutter, thus leading to user frustration and loss of yield.

Our analysis of this patent is as follows:

Z124’s patent US 9152179 B2 deals with Portrait dual display and landscape dual display.
Methods and devices for controlling the output shown associated with the application in connection with a large screen device given. Particularly, an application presented to the devices in a two-picture orientation used the first screen to display the control information, and use the second screen to show the inside information. An application presented to the creation of a two landscape orientation use the first screen and the second screen to show the inside information.

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Pyrazole derivatives used as CCR4 receptor antagonists

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The Glaxo Group Limited patent solves the following problem:

Chemokines are believed to play an important role in immune and inflammatory responses in a number of diseases or conditions of the CC-chemokine receptor 4 (CCR4) original clone from a basophilic cell line (Power et al, J. Biol. Chem.; 270: 19495: 1995). The small molecule CCR4 receptor antagonists known in the art, with examples that described in Andrews et al (mol Pharmacol 73: 855, 2008).

Our analysis of this patent is as follows:

Glaxo Group Limited’s patent US 8357716 B2 deals with Pyrazole derivatives used as CCR4 receptor antagonists.
Indazole compounds, processes for their preparation, intermediates used in these processes, pharmaceutical compositions containing such compounds and their use in therapy.

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Immune stimulatory infant nutrition

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The N.V. Nutricia patent solves the following problem:

Breastfeeding optimally supports the development of children and protects against infection. However, not all infants are in a position to receive human milk. It is therefore a continuing aim to provide infant formula, which simulates the functions of human milk. In addition to the desired compositional similarity between formula and human milk, it is also particularly desirable to mimic the protective effects of human milk. Human milk for example been shown that human milk protects against infections and allergies.

Our analysis of this patent is as follows:

N.V. Nutricia’s patent US 8114441 B2 deals with Immune stimulatory infant nutrition.
A nutritional or medicinal composition containing a fat component, a protein component and a carbohydrate component and comprising whey and casein. composition has a weight ratio of casein to whey is 1: 1 to 1: 2.4 and that the composition comprises: a) at least 3 grams arginine per 100 grams protein; b) at least 10 wt. % Linoleic acid based on total fatty acids; c) at least 1 wt. % Alpha linolenic acid based on total fatty acids; d) at least one long-chain polyunsaturated fatty acid in an amount exceeding 0.1 wt. % Based on total fatty acids. The long chain polyunsaturated fatty acid docosahexaenoic acid, arachidonic acid and eicosapentaenoic acid; e) 5 to 25 wt. % At least one polyunsaturated fatty acid based on total fatty acids; and f) 2 to 12 grams indigestible oligosaccharides with a degree of polymerization of 2 to 100 per 100 program dry weight of the composition. The composition reducesamong othersthe risks attached to feeding whey dominant formula.

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Computer implemented program, system and method for medical inventory management

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The The United States Of America As Represented By The Secretary Of The Navy patent solves the following problem:

The present invention provides a computer readable program, system and method for enabling a user to output a report estimated that needed medical supplies to base a choice of operating situation. Furthermore, a computer program read, systems and methods are provided for enabling a user to create a question about the relationship between patient conditions, work and medical supplies needed in certain places / situations. The source code for the calculation of Supplies Program version 1.1 computer program of the present invention to be submitted on CD-ROM as Appendix A here. The material on the CD-ROM that was included in the references.

Our analysis of this patent is as follows:

The United States Of America As Represented By The Secretary Of The Navy’s patent US 7707042 B1 deals with Computer implemented program, system and method for medical inventory management.
A system and method for estimation of necessary medical supplies based on a choice of predefined operational situation. A predefined operational scenarios to be modified, a new operational situation can be built, or a predefined operational scenarios can be imported from an external source. A computer-readable program, system and method are provided for enabling a user to create a question about the relationship between the patient's conditions, work and medical supplies needed in particular areas. The production of a report or inquiry made by reference to a database containing data about the patient's condition, functional areas of patient care (triage, operating room, etc.), equipment in defined functional areas, the work involved in the treatment of patients described circumstances, medical supplies required to perform each activity described, and the relationship therebetween, and determine necessary medical supplies based on the use of data input and data in the database.

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Protein hydrolysates enriched in peptides having a carboxy terminal proline residue

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The Dsm Ip Assets B.V. patent solves the following problem:

Enzyme hydrolysates of cow's milk or pieces of cow's milk only limited application in the food industry. Nevertheless, these hydrolysates occupy interesting wall space in the market, as evidenced by the large number of literature describing and claiming optimized processes for obtaining such hydrolysates. Milk or milk fractions were subjected to enzymes with proteolytic activity to produce the hydrolysates primarily to minimize the allergenicity of the product, abdominal facilitate uptake by offering an easily absorbed thinking, and to strengthen the protein acid products against precipitation during prolonged periods of storage.

Our analysis of this patent is as follows:

Dsm Ip Assets B.V.’s patent US 7309595 B2 deals with Protein hydrolysates enriched in peptides having a carboxy terminal proline residue.
The present invention provides an isolated polypeptide that proline specific endoprotease activity, selected from the group consisting of: (a) a polypeptide having an amino acid sequence having at least 40% amino acid identity with amino acids 1 to 526 of SEQ ID NO: 2 or a fragment thereof; (B) a polypeptide encoded by a polynucleotide that hybridizes under low Stringency conditions with (i) the nucleic acid of SEQ ID NO: 1 or a part thereof that is at least 80 % or 90% identical over 60, preferably over 100 nucleotides, more preferably at least 90% identical over 200 nucleotides, or (ii) a nucleic acid sequence that is complementary to the nucleic acid SEQ ID NO: 1.

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Polyamide thermoplastic compositions with improved impact strength properties

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The Arkema patent solves the following problem:

Our analysis of this patent is as follows:

Arkema’s patent US 7151136 B2 deals with Polyamide thermoplastic compositions with improved impact strength properties.
The invention relates to a polyamide-based thermoplastic composition comprising, in weight: 50 to 98 parts of a polyamide (A1) nondiamine; 0.2 to 40 parts, preferably 0.2 to 9 parts, a polyamide (A2) diamine, said polyamide (A2) different from the polyamide (A1) and the mass ratio (A2 ) / (A1) of less than 1; 1 to 60 parts, preferably 1 to 30 parts, of a reactive impact modifier (B) or a combination of modifiers comprising at least one reactive impact modifier (B ) or a combination (B) comprising at least one impact modifier and at least one reactive modifier. It also relates to an impact modifier composition and process for preparing a thermoplastic composition according to the invention in use as an impact modifier composition.

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Personal information card system

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The Drexler Technology Corporation patent solves the following problem:

Identification cards used in magnetic data strips with photographic prints of the card owner.

Our analysis of this patent is as follows:

Drexler Technology Corporation’s patent US 4745268 A deals with Personal information card system.
A system of wallet-sized visually read information related to a man made material disposed on a portion of a wallet-size card and machine readable information associated with those recorded in a laser recordable optical data storage strip disposed on the opposite side of the card. The visually read information may be a fingerprint or face done in conventional photography or with a laser. The data storage strip card would be a pre-formed strip laser recording material. Information spots recorded in the strip may be insurance, medical, banking, security or other transaction information. The two machines read information and read information read together with two optical systems, one disposed on each side of the card.

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Medical data card having internal illumination

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The Data Medi-Card, Inc. patent solves the following problem:

This creation relates generally to a medical data card containing a summary of the medical history will be involved in his current medical condition, and especially an internal illuminated card in this manner that the front and rear transparencies component in a relatively large data capacity, the data taken as read and read directly without the need for optical lens.

Our analysis of this patent is as follows:

Data Medi-Card, Inc.’s patent US 4575127 A deals with Medical data card having internal illumination.
An internal illuminated medical data card in a credit card format containing a summary of the medical history will be involved in his current medical condition. The card, which is laminated construction, includes a core panel formed in front and rear plastic section with light-passing possession, a metallized layer functioning as a double-who facing glass sandwiched therebetween. Depend on the respective faces of the core is the section in front of and behind the film transparencies containing medical data in a direct read scale, the combined data elements in the daily summary. The long side and one end of each core section is a concave formation to define reflective convex end where the light to enter the remaining flat end section passed so the convex end glass and by giving many internal reflection, causing the light to shine on transparencies to improve their readability.

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