Substituted diazine and triazine spleen tyrosine kinease (Syk) inhibitors

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The Merck Sharp & Dohme Corp. patent solves the following problem:

Spleen Tyrosine Kinase (SYK) is a protein tyrosine kinase described as a key mediator of immunoreceptor signaling a host of inflammatory cells including mast cells, B-cells, macrophages and neutrophils. These immunoreceptors, including Fc receptor and the B-cell receptor, is important for allergic diseases, and antibody-mediated autoimmune diseases and thus pharmacologically interfering SYK conceivably treat these diseases.

Our analysis of this patent is as follows:

Merck Sharp & Dohme Corp.’s patent US 9416111 B2 deals with Substituted diazine and triazine spleen tyrosine kinease (Syk) inhibitors.
invention provides certain substituted diazine and triazine compounds of Formula (I) (I) or pharmaceutically acceptable salts thereof, wherein R1, R2, P3, R4, rcy, CY, and t as described here. invention also provides pharmaceutical compositions comprising such compounds, and methods of using the compounds for treating diseases or conditions mediated spleen tyrosine kinase (SYK) kinase.

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Nutritional composition with probiotics

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The N.V. Nutricia patent solves the following problem:

Infants without intestinal flora at birth. As a result of contact with the mother during birth and subsequent feeding with human milk or formula milk, the intestinal flora rapidly. During the development, the intestinal flora is still immature and normal activities are weak. Human milk-fed infants are less afflicted by infections or diseases than formula-fed infants. Thus, human milk-fed children have less gastro-intestinal infections in terms of incidents and the duration, less atopic diseases such as allergies, eczema, less colics and cramps, and less constipation than formula-fed infants. pain came later in life, such as childhood obesity, diabetes, and asthma are related to the kind of feeding during the early stages of life, with human milk-fed infants for good .

Our analysis of this patent is as follows:

N.V. Nutricia’s patent US 9314047 B2 deals with Nutritional composition with probiotics.
A composition comprising Bifidobacterium breve, a non-digestible saccharide A and a non-digestible saccharide B, optionally with Lactobacillus paracasei and the use of said composition for the treatment and / or prevention of gastro-intestinal disorders, immune disorder and / or endocrine disorder.

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Chemoenzymatic synthesis of heparin and heparan sulfate analogs

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The The Regents Of The University Of California patent solves the following problem:

Our analysis of this patent is as follows:

The Regents Of The University Of California’s patent US 9290530 B2 deals with Chemoenzymatic synthesis of heparin and heparan sulfate analogs.
The present invention provides a one-pot multi-enzyme method for preparing the UDP-sugars from simple sugar starting materials. invention also provides a one-pot multi-enzyme process for the preparation of oligosaccharides from simple sugar starting materials.

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Methods for promoting neuronal development and/or health

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The Mead Johnson Nutrition Company patent solves the following problem:

The brain has only 2% of the total weight of the body, but it is a difficult organ used in 30% of calories in the day and nutrients. (Harris, JJ et al, The Energetics of CNS White Matter jour Neuroscience, January 2012: 32 (1): 356-371). The human brain and nervous system begin construction early in prenatal life and the two continue to develop until the age of three. This early development may have lifelong effects on overall brain and nervous system health. Therefore, brain nutrients become important additives in the diet of infants, children and pregnant and lactating women because of their ability to improve early brain development and the prevention and protection from brain and nervous system injury or illness. Moreover, brain nutrition is important for adults, as many nutrients to the developing nervous system to repair and provide neuroprotective benefits to health.

Our analysis of this patent is as follows:

Mead Johnson Nutrition Company’s patent US 9226914 B2 deals with Methods for promoting neuronal development and/or health.
Expressed the way for the development of neuronal health and / or development of a subject by providing nutritional composition comprising docosahexaenoic acid and alpha-lipoic acid. The nutritional composition may further include lactoferrin, a prebiotic, a probiotic, and mixtures thereof. Further disclosed are methods for the rapid development of neuronal activity and / or strengthen the electrochemical synapse signaling by providing the nutritional composition (s) disclosed in a target subject.

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Dynamic expansion of data visualizations

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The Domo, Inc. patent solves the following problem:

Our analysis of this patent is as follows:

Domo, Inc.’s patent US 9202297 B1 deals with Dynamic expansion of data visualizations.
A user can dynamically present and control the performance of secondary visualizations of data based on a selected element in a main data-aw. Introduction of secondary data visualizations presented as the user interact with the first look. In response to user input, the introduction can be dynamically expanded, allowing a user to dynamically drill down to select the elements in the first data-aw. Any input mechanisms should be used, including for example, an action like a two-finger spreading in motion to celebrate the introduction in secondary visualizations, where the axis defined by two point of contact determines that showed advanced secondary visualizations highlighted and / or expanded. In various embodiments, a hierarchy of visualizations can be strengthened, and the user can navigate between the two or more levels of interactive visualizations same way.

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Process for the production of ultrapure galacto-oligosaccharides

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The Ritter Pharmaceuticals, Inc. patent solves the following problem:

Our analysis of this patent is as follows:

Ritter Pharmaceuticals, Inc.’s patent US 9200303 B2 deals with Process for the production of ultrapure galacto-oligosaccharides.
The present invention describes a process for preparing pure (95%) galacto-oligosaccharides (gos), starting from the forced low purities by the use of continuous microbiological preparations involving Saccharomyces cerevisiae and streptococcus thermophilics.

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Non-digestible oligosaccharides for oral induction of tolerance against dietary proteins

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The N.V. Nutricia patent solves the following problem:

During the common process of nutrition in food proteins presented to the immune system through the gastro-intestinal tract without an immune response to ingested nutrients. This unresponsiveness is called oral immune tolerance or oral tolerance. The induction of oral immune tolerance is especially relevant for children, after being exposed for the first time to eat protein and adapt to it. If the children's oral immune tolerance is established, food allergies occur. The people who suffer from food allergies requires a specific food protein food to avoid.

Our analysis of this patent is as follows:

N.V. Nutricia’s patent US 9060996 B2 deals with Non-digestible oligosaccharides for oral induction of tolerance against dietary proteins.
Composition and the manner in which the child nutrition partially hydrolysed protein and non-digestible oligosaccharides for use in the induction of oral tolerance against the native of dietary protein.

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High energy liquid enteral nutritional composition

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The N. V. Nutricia patent solves the following problem:

The present invention relates in general to a liquid enteral composition for providing nutrition, or as a supplement, or as a complete nutrition, with a high energy inside.

Our analysis of this patent is as follows:

N. V. Nutricia’s patent US 8999423 B2 deals with High energy liquid enteral nutritional composition.
High energy and high protein liquid nutrition enteral composition which includes micellar casein and caseinate, a optionally a small amount of whey.

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Low protein infant formula with increased essential amino acids

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The N.V. Nutricia patent solves the following problem:

Knowledge of the basic amino acid in (preterm) infants is important because excessive or insufficient drinking may lead to long-term illnesses such as obesity (Singhal et al (2002) Am J Clin Nutr 75: . 993-9) or suboptimal growth and impaired neurodevelopment outcome (Stephens et al (2009) Pediatrics 2009; 123: 1337-43).

Our analysis of this patent is as follows:

N.V. Nutricia’s patent US 8987196 B2 deals with Low protein infant formula with increased essential amino acids.
The present invention of an improved balance of essential branched chain amino acid leucine, isoleucine and valine in baby formula.

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Vehicle fuel economy system

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The StormBlok Systems, Inc. patent solves the following problem:

Now most tractor-trailers and about 6-7 mpg fuel leaving significant potential for improving fuel economy of tractor-trailers. Reduced fuel consumption of tractor-trailers that directly impact cost of transportation of goods, serving businesses and consumers alike.

Our analysis of this patent is as follows:

StormBlok Systems, Inc.’s patent US 8985677 B2 deals with Vehicle fuel economy system.
A fairing assembly for a trailer with a wheel set and a hook, the fairing assembly consisting of a fairing connected to an underside of the trailer intermediate hooks, and the wheels set, the fairing including (i) a pair of opposing lateral surfaces separated by a distance, (ii) a lower surface spaced from the underside of the trailer, and (ii) a first face, the first face substantially spanning the distance, where the first face includes an intake opening, wherein at least one of the lower face or the lateral surfaces include an exit opening, and a flow path fluidly connecting the intake openings and exit openings.

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