Neurogenesis screening method and uses thereof

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The Mead Johnson Nutrition Company patent solves the following problem:

The brain has only 2% of the total weight of the body, but it is a difficult organ used in 30% of calories in the day and nutrients. (Harris, JJ et al, The Energetics of CNS White Matter jour Neuroscience, January 2012: 32 (1): 356-371). The human brain and nervous system begin construction early in prenatal life and the two continue to develop until the age of three. This early development may have lifelong effects on overall brain and nervous system health. Therefore, brain nutrients become important additives in the diet of infants, children and pregnant and lactating women because of their ability to improve early brain development and the prevention and protection from brain and nervous system injury or illness. Moreover, brain nutrition is important for adults, as many nutrients to the developing nervous system to repair and provide neuroprotective benefits to health.

Our analysis of this patent is as follows:

Mead Johnson Nutrition Company’s patent US 9351978 B2 deals with Neurogenesis screening method and uses thereof.
If there are methods for detecting and / or evidence of neurogenesis effect on cholesterol and / or oxysterol using adipose-derived stem cells (ADSCs). Also given are the ways to promote neurogenesis in ADSCs. It also gives the approach to the use of cholesterol and / or production oxysterol for a neurologic component to be incorporated into a nutritional composition for increasing neurogenesis in a pediatric subject.

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Nutritional compositions with coated lipid globules

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The N.V. Nutricia patent solves the following problem:

Breast-feeding is the preferred method of infant feeding. However, there are circumstances that make breast-feeding impossible or less attractive. In the case of children's formula is a good alternative. The composition of modern infant formulas is adapted in such a way that will meet many of the special nutritional needs of the fast growing and developing infant.

Our analysis of this patent is as follows:

N.V. Nutricia’s patent US 9345259 B2 deals with Nutritional compositions with coated lipid globules.
The present invention relates to a nutritional composition for children and / or children consisting of a lipid component has a lipid globules coated with polar lipid. composition can be used to prevent obesity and / or improve body composition later in life. Said liquid comprises 10-50 wt% vegetable based liquid dry weight of the composition, and (i) 0.5-20 wt% phospholipids based on total weight, or (ii) 0.6-25 wt% of polar lipid based on total lipid, where polar lipid is the sum of phospholipids, glycosphingolipids and cholesterol, and said composition comprising lipid globules with a core comprising said vegetable lipid and a coating comprising said phospholipids or polar lipid.

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Dry powder pharmaceutical composition for inhalation

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The Daiichi Sankyo Company, Limited patent solves the following problem:

Japanese Patent No. 3209946 (Patent Document 1) discloses compounds with neuraminidase inhibitory activity, including the compound represented by formula (I) shown below. The compound represented by formula (I) have excellent neuraminidase inhibitory activity and is expected to be useful as a drug for treating and preventing influenza virus infection. Japanese Patent No. 4205314 (Patent Document 2) revealed a concentration of the compound represented by formula (I) can remain on for a long time in the respiratory tissues like lung (Patent Document 2).

Our analysis of this patent is as follows:

Daiichi Sankyo Company, Limited’s patent US 9339487 B2 deals with Dry powder pharmaceutical composition for inhalation.
There was a dry powder pharmaceutical composition for inhalation is useful for preventing and / or treating influenza virus infections included as a medicinal component of a compound represented by formula (I): and optionally a compound represented by formula (II): a pharmacologically acceptable salt thereof, or a hydrate thereof.

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Aminopyrimidines as Syk inhibitors

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The Merck Sharp & Dohme Corp. patent solves the following problem:

Spleen Tyrosine Kinase (SYK) is a protein tyrosine kinase described as a key mediator of immunoreceptor signaling a host of inflammatory cells including mast cells, B-cells, macrophages and neutrophils. These immunoreceptors, including Fc receptor and the B-cell receptor, is important for allergic diseases, and antibody-mediated autoimmune diseases and thus, pharmacologically interfering with SYK conceivably treat these diseases.

Our analysis of this patent is as follows:

Merck Sharp & Dohme Corp.’s patent US 9290490 B2 deals with Aminopyrimidines as Syk inhibitors.
The present invention provides new pyrimidine amines of formula I are potent inhibitor of spleen tyrosine kinase, and is useful in the treatment and prevention of diseases mediated by said enzyme, such as asthma, COPD, rheumatoid arthritis and cancer.

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Method for initiating a consumable-based cycle of operation

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The Whirlpool Corportion patent solves the following problem:

The invention relates to the use of consumables through a communication device on a network creatures, and especially, the choice of appliance from a plurality of appliances that have an event associated with consumable.

Our analysis of this patent is as follows:

Whirlpool Corportion’s patent US 9277188 B2 deals with Method for initiating a consumable-based cycle of operation.
One way to start a cycle of operation based on a consumable includes providing a consumable reader with a software architecture configured to image data, talk on the one network, and recognition functionalities of appliances based on a unique identification associated with each time a functionality, imaging data of the consumable use consumable reader; Taking cycle data associated with the consumable based on imaged data; know, the software architecture in at least one activity associated with the data cycle; selecting from the plurality of appliances is an appliance with at least one activity using the unique identifier associated with a time of at least one event; and communicating the data cycle to the selected appliance on the network the appliances where the selected appliance becomes a cycle of operation associated with the consumable usage data cycle.

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Dosage and formulation

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The Almirall, S.A. patent solves the following problem:

Aclidinium bromide is 3 (R) – (2-hydroxy-2,2-dithien-2-ylacetoxy) -1- (3-phenoxypropyl) -1-azoniabicyclo [2.2.2] octane bromide, described in, for example WO 0104118. Although this compound is known as a long-acting anticholinergic useful in the treatment of respiratory diseases, the optimal dose was not disclosed.

Our analysis of this patent is as follows:

Almirall, S.A.’s patent US 9254262 B2 deals with Dosage and formulation.
The present disclosure relates to pharmaceutical compositions for inhalation comprising aclidinium in the form of a dry powder in a pharmaceutically acceptable salt in admixture with a pharmaceutically acceptable dry powder carrier, providing a metered nominal dose of aclidinium equivalent to about 200 micrograms aclidinium bromide.

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Methods for promoting neuronal development and/or health

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The Mead Johnson Nutrition Company patent solves the following problem:

The brain has only 2% of the total weight of the body, but it is a difficult organ used in 30% of calories in the day and nutrients. (Harris, JJ et al, The Energetics of CNS White Matter jour Neuroscience, January 2012: 32 (1): 356-371). The human brain and nervous system begin construction early in prenatal life and the two continue to develop until the age of three. This early development may have lifelong effects on overall brain and nervous system health. Therefore, brain nutrients become important additives in the diet of infants, children and pregnant and lactating women because of their ability to improve early brain development and the prevention and protection from brain and nervous system injury or illness. Moreover, brain nutrition is important for adults, as many nutrients to the developing nervous system to repair and provide neuroprotective benefits to health.

Our analysis of this patent is as follows:

Mead Johnson Nutrition Company’s patent US 9241923 B2 deals with Methods for promoting neuronal development and/or health.
The present disclosure is directed to methods for improving neuronal health and / or development of a subject by providing nutritional composition comprising a neurologic component, wherein the neurologic component to develop the brain and nervous system development and further provide neurological protection and repair. The neurologic component may include lactoferrin, zinc sulfate, one or more organosulfur compounds, and mixtures thereof.

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Automated suggested alerts based on natural language and user profile analysis

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The Domo, Inc. patent solves the following problem:

Our analysis of this patent is as follows:

Domo, Inc.’s patent US 9235978 B1 deals with Automated suggested alerts based on natural language and user profile analysis.
An alert suggestion generator to automatically suggest alert for a user based on user input. The user input may include natural language text and / or user actions that suggestion generator able to generate alert that there is a high tendency to relate, and therefore will, to the user. Each alert will have a reason for existence as the passage of time, the measure of a numeric metric, or other factors. Each alert also has a state proclamation clear how the user is announced. The alert suggestion generator to get a user profile of the user in addition to determining how alert that is most relevant to the user. The user will be queried to confirm the alert, and the alert that they set. Partial alarm will be generated and user can be queried for the trigger condition and / or state announcement needed to complete the alert.

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2-Pyridyl carboxamide-containing spleen tyrosine kinase (SYK) inhibitors

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The Merck Sharp & Dohme Corp. patent solves the following problem:

Spleen Tyrosine Kinase (SYK) is a protein tyrosine kinase described as a key mediator of immunoreceptor signaling a host of inflammatory cells including mast cells, B-cells, macrophages and neutrophils. These immunoreceptors, including Fc receptor and the B-cell receptor, is important for allergic diseases, and antibody-mediated autoimmune diseases and thus pharmacologically interfering SYK conceivably treat these diseases.

Our analysis of this patent is as follows:

Merck Sharp & Dohme Corp.’s patent US 9216173 B2 deals with 2-Pyridyl carboxamide-containing spleen tyrosine kinase (SYK) inhibitors.
invention provides certain 2-pyridyl formamide-containing compounds of Formula (I) or pharmaceutically acceptable salts thereof, wherein A and B as described here. invention also provides pharmaceutical compositions comprising such compounds, and methods of using the compounds for treating diseases or conditions mediated spleen tyrosine kinase (SYK) kinase.

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Compositions having reduced frictional coefficient, method of manufacture thereof and articles comprising the same

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The Sabic Global Technologies B.V. patent solves the following problem:

It disclosure relates to compositions that reduce frictional coefficients, means to do so, and articles comprising the same.

Our analysis of this patent is as follows:

Sabic Global Technologies B.V.’s patent US 9169371 B2 deals with Compositions having reduced frictional coefficient, method of manufacture thereof and articles comprising the same.
Expressed here is a composition consisting of an organic polymer and about 2 to 10 weight percent of an ionic liquid. The ionic liquid can be a halogenated or non-halogenated ionic liquid. Also disclosed in articles made from the composition.

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