BTK inhibitors

Be the First-to-File and Protect your earth-moving ideas with PowerPatent software service for Online Patent Application

The Merck Sharp & Dohme Corp. patent solves the following problem:

B lymphocyte activation is key to the generation of adaptive immune responses. Derailed B lymphocyte activation is a sign of many autoimmune diseases and in the modulation of the immune response and therapeutic interest. Recently the success of B cell therapy in autoimmune disease is established. Treatment of rheumatoid arthritis (RA) patients with Rituximab (anti-CD20 therapy) is an accepted clinical therapy today. More recent clinical trial studies showed that treatment with Rituximab also ameliorates symptoms of the disease in relapsing remitting multiple sclerosis (RRMS) and systemic lupus erythematosus (murder) patients. This success supports the potential for future therapies for autoimmune diseases targeted B cell immunity.

Our analysis of this patent is as follows:

Merck Sharp & Dohme Corp.’s patent US 9446130 B2 deals with BTK inhibitors.
The present invention provides Bruton's tyrosine kinase (Btk) inhibitor compounds according to Formula I or pharmaceutically acceptable salt thereof. Formula I or a pharmaceutically acceptable salt thereof or pharmaceutical compositions comprising these compounds and their use in therapy. In particular, the present invention relates to the use of Btk inhibitor compounds for the treatment of Btk mediated disorder.

The revolutionary TRAN&ASSOCIATES provides patent creation and management tools to help inventors protect their inventions using the patent system. Full lawyer support to complete and file the application is available.

Aerodynamic structures secured to the underbody of cargo bodies

You’ve invested time, talent, and energy into making a dent in the universe with your invention and ideas. Now it’s time to make sure it’s protected with a PowerPatent Utility, Provisional or Design Patent Application

The Stemco Lp patent solves the following problem:

Trucking is the primary means of long-distance and short-haul transportation of goods and materials in the United States, and in many other countries. Trucks often include a motorized cab where the driver sits and working on cars. cab attached to a box-like cargo section. Smaller trucks often include an integrated cargo section sitting in a unified framework which extends from the front wheels to the rear wheel assembly. The larger trucks often includes a detachable cab unit, with many driven axles, and a special trailer with a long box-like cargo units served on two or more phrases assemblies wheels. These trucks assemblages commonly called semi-trailers or tractor trailers. Most modern trucks' cabs, especially for tractor trailers, fitted with aerodynamic fairings on the roof, side and front. These fairings to help direct air over the exposed surface of the box-like cargo body, generally gave higher (a few feet) than the average roof cab. The flat, projecting front face of a cargo body is a strong source of drag on the cab roof. The use of the front-mounted aerodynamic fairings in recent years have served to significantly lower drag and, therefore, raise fuel economy for trucks, especially those traveling at high speed in the open roads.

Our analysis of this patent is as follows:

Stemco Lp’s patent US 9440689 B1 deals with Aerodynamic structures secured to the underbody of cargo bodies.
A flight underbody fairing or skirt that is attached to the rear wheels or bogeys in a cargo truck bodies generally can be slidably adjusted fore and aft along the cargo body. The various embodiments allow for a skirt that attaches bogeys in a cargo truck body and given back to the plane behind the trailer, and a retractable nature to allow for slidable change bogeys fore and aft along the cargo body for the purpose of continuing streamlined flow along the side of a cargo truck body equipped with a side of the border before the bogeys. In various embodiments of the invention, the retractable nature of the invention allows for a continuous edge surface of the plane with the side of the truck cargo bodies came from the back bogeys truck cargo plane body, without attention bogey position.

The revolutionary TRAN&ASSOCIATES provides patent creation and management tools to help inventors protect their inventions using the patent system. Full lawyer support to complete and file the application is available.

Substituted diazine and triazine spleen tyrosine kinease (Syk) inhibitors

Use PowerPatent’s Online Patent Filing Service to get quick patent protection for your great idea.

The Merck Sharp & Dohme Corp. patent solves the following problem:

Spleen Tyrosine Kinase (SYK) is a protein tyrosine kinase described as a key mediator of immunoreceptor signaling a host of inflammatory cells including mast cells, B-cells, macrophages and neutrophils. These immunoreceptors, including Fc receptor and the B-cell receptor, is important for allergic diseases, and antibody-mediated autoimmune diseases and thus pharmacologically interfering SYK conceivably treat these diseases.

Our analysis of this patent is as follows:

Merck Sharp & Dohme Corp.’s patent US 9416111 B2 deals with Substituted diazine and triazine spleen tyrosine kinease (Syk) inhibitors.
invention provides certain substituted diazine and triazine compounds of Formula (I) (I) or pharmaceutically acceptable salts thereof, wherein R1, R2, P3, R4, rcy, CY, and t as described here. invention also provides pharmaceutical compositions comprising such compounds, and methods of using the compounds for treating diseases or conditions mediated spleen tyrosine kinase (SYK) kinase.

The revolutionary TRAN&ASSOCIATES provides patent creation and management tools to help inventors protect their inventions using the patent system. Full lawyer support to complete and file the application is available.

User interface with independent drawer control

Protect your invention by filing a Provisional or Utility Patent Application using our software today! It’s easy and fully backed by patent lawyers – and you don’t have to pay until you’re done.

The Z124 patent solves the following problem:

While the computing and communications functions for handheld devices Computing becomes more powerful, the user interface and display elements such devices have evolved by trying to adapt user interface regime for the personal computer for use in handheld devices Computing . However, this attempt to adapt the user interface of the regime met with various obstacles.

Our analysis of this patent is as follows:

Z124’s patent US 9405444 B2 deals with User interface with independent drawer control.
Methods and apparatus for controlling the display of one or more drawers with a user interface to provide a new user interface interaction. The drawers can be opened in response to a motion input to display the data announcement, application data, contact data, calendar data, weather data, and the drawers can be opened and / or closed individually or collectively. For example, a character in action (eg, a place of action) may determine that the drawer was opened in response to the motion input.

The revolutionary TRAN&ASSOCIATES provides patent creation and management tools to help inventors protect their inventions using the patent system. Full lawyer support to complete and file the application is available.

Neurogenesis screening method and uses thereof

Patent Registration – Protect your earth-moving ideas with PowerPatent software service for Online Patent Application

The Mead Johnson Nutrition Company patent solves the following problem:

The brain has only 2% of the total weight of the body, but it is a difficult organ used in 30% of calories in the day and nutrients. (Harris, JJ et al, The Energetics of CNS White Matter jour Neuroscience, January 2012: 32 (1): 356-371). The human brain and nervous system begin construction early in prenatal life and the two continue to develop until the age of three. This early development may have lifelong effects on overall brain and nervous system health. Therefore, brain nutrients become important additives in the diet of infants, children and pregnant and lactating women because of their ability to improve early brain development and the prevention and protection from brain and nervous system injury or illness. Moreover, brain nutrition is important for adults, as many nutrients to the developing nervous system to repair and provide neuroprotective benefits to health.

Our analysis of this patent is as follows:

Mead Johnson Nutrition Company’s patent US 9351978 B2 deals with Neurogenesis screening method and uses thereof.
If there are methods for detecting and / or evidence of neurogenesis effect on cholesterol and / or oxysterol using adipose-derived stem cells (ADSCs). Also given are the ways to promote neurogenesis in ADSCs. It also gives the approach to the use of cholesterol and / or production oxysterol for a neurologic component to be incorporated into a nutritional composition for increasing neurogenesis in a pediatric subject.

The revolutionary TRAN&ASSOCIATES provides patent creation and management tools to help inventors protect their inventions using the patent system. Full lawyer support to complete and file the application is available.

Nutritional compositions with coated lipid globules

You’ve invested time, talent, and energy into making a dent in the universe with your invention and ideas. Now it’s time to make sure it’s protected with PowerPatent’s Utility, Provisional or Design Patent Filing Software

The N.V. Nutricia patent solves the following problem:

Breast-feeding is the preferred method of infant feeding. However, there are circumstances that make breast-feeding impossible or less attractive. In the case of children's formula is a good alternative. The composition of modern infant formulas is adapted in such a way that will meet many of the special nutritional needs of the fast growing and developing infant.

Our analysis of this patent is as follows:

N.V. Nutricia’s patent US 9345259 B2 deals with Nutritional compositions with coated lipid globules.
The present invention relates to a nutritional composition for children and / or children consisting of a lipid component has a lipid globules coated with polar lipid. composition can be used to prevent obesity and / or improve body composition later in life. Said liquid comprises 10-50 wt% vegetable based liquid dry weight of the composition, and (i) 0.5-20 wt% phospholipids based on total weight, or (ii) 0.6-25 wt% of polar lipid based on total lipid, where polar lipid is the sum of phospholipids, glycosphingolipids and cholesterol, and said composition comprising lipid globules with a core comprising said vegetable lipid and a coating comprising said phospholipids or polar lipid.

The revolutionary TRAN&ASSOCIATES provides patent creation and management tools to help inventors protect their inventions using the patent system. Full lawyer support to complete and file the application is available.

Chemoenzymatic synthesis of heparin and heparan sulfate analogs

Apply for Patent – Protect your earth-moving ideas with PowerPatent software service for Online Patent Application

The The Regents Of The University Of California patent solves the following problem:

Our analysis of this patent is as follows:

The Regents Of The University Of California’s patent US 9290530 B2 deals with Chemoenzymatic synthesis of heparin and heparan sulfate analogs.
The present invention provides a one-pot multi-enzyme method for preparing the UDP-sugars from simple sugar starting materials. invention also provides a one-pot multi-enzyme process for the preparation of oligosaccharides from simple sugar starting materials.

The revolutionary TRAN&ASSOCIATES provides patent creation and management tools to help inventors protect their inventions using the patent system. Full lawyer support to complete and file the application is available.

Multicomponent improved vehicle fuel economy system

You’ve invested time, talent, and energy into making a dent in the universe with your invention and ideas. Now it’s time for Utility, Provisional or Design Patent Creation with PowerPatent software and services.

The Ekostinger, Inc. patent solves the following problem:

Now most tractor-trailers and about 6-7 mpg fuel leaving significant potential for improving fuel economy of tractor-trailers. Reduced fuel consumption of tractor-trailers that directly impact cost of transportation of goods, serving businesses and consumers alike.

Our analysis of this patent is as follows:

Ekostinger, Inc.’s patent US 9283997 B2 deals with Multicomponent improved vehicle fuel economy system.
A semitrailer consisting of a main frame with a hook, an axle assembly connected to the first frame, the axle assembly including at least two wheels in rotation on the the first frame, a fairing connected to an underside of the semitrailer intermediate hook and axle assembly, the fairing including a pair of lateral surface, a lower surface spaced from the underside semitrailer, and a first surface, wherein the first surface includes an intake openings, and where at least one of the lower face or the lateral surfaces include an exit opening, and a flow path fluidly connecting the intake openings and exit openings.

The revolutionary TRAN&ASSOCIATES provides patent creation and management tools to help inventors protect their inventions using the patent system. Full lawyer support to complete and file the application is available.

Dosage and formulation

Be the First-to-File and Protect your earth-moving ideas with PowerPatent software service for Online Patent Application

The Almirall, S.A. patent solves the following problem:

Aclidinium bromide is 3 (R) – (2-hydroxy-2,2-dithien-2-ylacetoxy) -1- (3-phenoxypropyl) -1-azoniabicyclo [2.2.2] octane bromide, described in, for example WO 0104118. Although this compound is known as a long-acting anticholinergic useful in the treatment of respiratory diseases, the optimal dose was not disclosed.

Our analysis of this patent is as follows:

Almirall, S.A.’s patent US 9254262 B2 deals with Dosage and formulation.
The present disclosure relates to pharmaceutical compositions for inhalation comprising aclidinium in the form of a dry powder in a pharmaceutically acceptable salt in admixture with a pharmaceutically acceptable dry powder carrier, providing a metered nominal dose of aclidinium equivalent to about 200 micrograms aclidinium bromide.

The revolutionary TRAN&ASSOCIATES provides patent creation and management tools to help inventors protect their inventions using the patent system. Full lawyer support to complete and file the application is available.

Process for the production of ultrapure galacto-oligosaccharides

Use PowerPatent’s Online Patent Filing Service to get quick patent protection for your great idea.

The Ritter Pharmaceuticals, Inc. patent solves the following problem:

Our analysis of this patent is as follows:

Ritter Pharmaceuticals, Inc.’s patent US 9200303 B2 deals with Process for the production of ultrapure galacto-oligosaccharides.
The present invention describes a process for preparing pure (95%) galacto-oligosaccharides (gos), starting from the forced low purities by the use of continuous microbiological preparations involving Saccharomyces cerevisiae and streptococcus thermophilics.

The revolutionary TRAN&ASSOCIATES provides patent creation and management tools to help inventors protect their inventions using the patent system. Full lawyer support to complete and file the application is available.