BTK inhibitors

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The Merck Sharp & Dohme Corp. patent solves the following problem:

B lymphocyte activation is key to the generation of adaptive immune responses. Derailed B lymphocyte activation is a sign of many autoimmune diseases and in the modulation of the immune response and therapeutic interest. Recently the success of B cell therapy in autoimmune disease is established. Treatment of rheumatoid arthritis (RA) patients with Rituximab (anti-CD20 therapy) is an accepted clinical therapy today. More recent clinical trial studies showed that treatment with Rituximab also ameliorates symptoms of the disease in relapsing remitting multiple sclerosis (RRMS) and systemic lupus erythematosus (murder) patients. This success supports the potential for future therapies for autoimmune diseases targeted B cell immunity.

Our analysis of this patent is as follows:

Merck Sharp & Dohme Corp.’s patent US 9446130 B2 deals with BTK inhibitors.
The present invention provides Bruton's tyrosine kinase (Btk) inhibitor compounds according to Formula I or pharmaceutically acceptable salt thereof. Formula I or a pharmaceutically acceptable salt thereof or pharmaceutical compositions comprising these compounds and their use in therapy. In particular, the present invention relates to the use of Btk inhibitor compounds for the treatment of Btk mediated disorder.

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Aerodynamic structures secured to the underbody of cargo bodies

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The Stemco Lp patent solves the following problem:

Trucking is the primary means of long-distance and short-haul transportation of goods and materials in the United States, and in many other countries. Trucks often include a motorized cab where the driver sits and working on cars. cab attached to a box-like cargo section. Smaller trucks often include an integrated cargo section sitting in a unified framework which extends from the front wheels to the rear wheel assembly. The larger trucks often includes a detachable cab unit, with many driven axles, and a special trailer with a long box-like cargo units served on two or more phrases assemblies wheels. These trucks assemblages commonly called semi-trailers or tractor trailers. Most modern trucks' cabs, especially for tractor trailers, fitted with aerodynamic fairings on the roof, side and front. These fairings to help direct air over the exposed surface of the box-like cargo body, generally gave higher (a few feet) than the average roof cab. The flat, projecting front face of a cargo body is a strong source of drag on the cab roof. The use of the front-mounted aerodynamic fairings in recent years have served to significantly lower drag and, therefore, raise fuel economy for trucks, especially those traveling at high speed in the open roads.

Our analysis of this patent is as follows:

Stemco Lp’s patent US 9440689 B1 deals with Aerodynamic structures secured to the underbody of cargo bodies.
A flight underbody fairing or skirt that is attached to the rear wheels or bogeys in a cargo truck bodies generally can be slidably adjusted fore and aft along the cargo body. The various embodiments allow for a skirt that attaches bogeys in a cargo truck body and given back to the plane behind the trailer, and a retractable nature to allow for slidable change bogeys fore and aft along the cargo body for the purpose of continuing streamlined flow along the side of a cargo truck body equipped with a side of the border before the bogeys. In various embodiments of the invention, the retractable nature of the invention allows for a continuous edge surface of the plane with the side of the truck cargo bodies came from the back bogeys truck cargo plane body, without attention bogey position.

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Ingredients for inhalation and methods for making the same

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The Vectura Limited patent solves the following problem:

Our analysis of this patent is as follows:

Vectura Limited’s patent US 9381189 B2 deals with Ingredients for inhalation and methods for making the same.
A method of processing an active ingredient, the method comprising submit a pharmaceutically active substances in excipients and / or additives to compression and shearing forces. The invention also relates to compositions comprising an active prepared by the procedure.

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Polymorphic crystal forms of 5-(2-{[6-(2,2-difluoro-2-phenylethoxy)hexyl]amino}-1-(R)-hydroxyethyl)-8-hydroxyquinolin-2(1H)-one, heminapadisytlate as agonist of the 2 adrenergic receptor

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The Almirall, S.A. patent solves the following problem:

5- (2 – {[6- (2,2-difluoro-2-phenylethoxy) hexyl] amino} -1 (R) -hydroxyethyl) -8-hydroxyquinolin-2 (1H) -one (Compound I) is a valiant 2 adrenoceptor agonist first disclosed in WO 2006/122788. This compound of the following chemical formula.

Our analysis of this patent is as follows:

Almirall, S.A.’s patent US 9346759 B2 deals with Polymorphic crystal forms of 5-(2-{[6-(2,2-difluoro-2-phenylethoxy)hexyl]amino}-1-(R)-hydroxyethyl)-8-hydroxyquinolin-2(1H)-one, heminapadisytlate as agonist of the 2 adrenergic receptor.
The present invention is directed to novel polymorphic crystalline form of a 5- (2 – {[6- (2,2-difluoro-2-phenylethoxy) hexyl] amino} -1- (R) -hydroxyethyl) -8-hydroxyquinolin- 2 (1H) -one, heminapadisylate. invention is also directed to pharmaceutical compositions comprising said polymorphic crystalline forms, ways to use them to treat respiratory diseases associated with 2 adrenergic receptor activity and a process to prepare the polymorphic crystalline forms.

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Nutritional compositions with coated lipid globules

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The N.V. Nutricia patent solves the following problem:

Breast-feeding is the preferred method of infant feeding. However, there are circumstances that make breast-feeding impossible or less attractive. In the case of children's formula is a good alternative. The composition of modern infant formulas is adapted in such a way that will meet many of the special nutritional needs of the fast growing and developing infant.

Our analysis of this patent is as follows:

N.V. Nutricia’s patent US 9345259 B2 deals with Nutritional compositions with coated lipid globules.
The present invention relates to a nutritional composition for children and / or children consisting of a lipid component has a lipid globules coated with polar lipid. composition can be used to prevent obesity and / or improve body composition later in life. Said liquid comprises 10-50 wt% vegetable based liquid dry weight of the composition, and (i) 0.5-20 wt% phospholipids based on total weight, or (ii) 0.6-25 wt% of polar lipid based on total lipid, where polar lipid is the sum of phospholipids, glycosphingolipids and cholesterol, and said composition comprising lipid globules with a core comprising said vegetable lipid and a coating comprising said phospholipids or polar lipid.

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Chemoenzymatic synthesis of heparin and heparan sulfate analogs

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The The Regents Of The University Of California patent solves the following problem:

Our analysis of this patent is as follows:

The Regents Of The University Of California’s patent US 9290530 B2 deals with Chemoenzymatic synthesis of heparin and heparan sulfate analogs.
The present invention provides a one-pot multi-enzyme method for preparing the UDP-sugars from simple sugar starting materials. invention also provides a one-pot multi-enzyme process for the preparation of oligosaccharides from simple sugar starting materials.

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Methods for promoting neuronal development and/or health

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The Mead Johnson Nutrition Company patent solves the following problem:

The brain has only 2% of the total weight of the body, but it is a difficult organ used in 30% of calories in the day and nutrients. (Harris, JJ et al, The Energetics of CNS White Matter jour Neuroscience, January 2012: 32 (1): 356-371). The human brain and nervous system begin construction early in prenatal life and the two continue to develop until the age of three. This early development may have lifelong effects on overall brain and nervous system health. Therefore, brain nutrients become important additives in the diet of infants, children and pregnant and lactating women because of their ability to improve early brain development and the prevention and protection from brain and nervous system injury or illness. Moreover, brain nutrition is important for adults, as many nutrients to the developing nervous system to repair and provide neuroprotective benefits to health.

Our analysis of this patent is as follows:

Mead Johnson Nutrition Company’s patent US 9226914 B2 deals with Methods for promoting neuronal development and/or health.
Expressed the way for the development of neuronal health and / or development of a subject by providing nutritional composition comprising docosahexaenoic acid and alpha-lipoic acid. The nutritional composition may further include lactoferrin, a prebiotic, a probiotic, and mixtures thereof. Further disclosed are methods for the rapid development of neuronal activity and / or strengthen the electrochemical synapse signaling by providing the nutritional composition (s) disclosed in a target subject.

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Automatic web service monitoring

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The Domo, Inc. patent solves the following problem:

Our analysis of this patent is as follows:

Domo, Inc.’s patent US 9191285 B1 deals with Automatic web service monitoring.
According to various embodiments, the present invention provides a live site performance monitoring in the context of reasonable resource hierarchies found in cloud computing systems. In particular, in an image, the system of the present invention facilitates monitoring of new services Computing without necessarily requires clear knowledge of these new services. Such services may include, for example and without limitation, given the use of an image that State Transfer (REST) ​​architecture, although the techniques described herein may also be used in other architectures. In one embodiment, the system of the present invention works by automatically creating groups of things for performance monitoring, based on the hierarchy of a type. Heuristics can be used to determine aggregatable hierarchy nodes.

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Devices and methods for reducing vehicle drag

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The Smarttruck Systems, Llc patent solves the following problem:

An ongoing effort to reduce the drag in vehicular structures is of great importance as the fuel economy will be a greater consideration in vehicular design. As the drag of a car increases, the amount of fuel needed to move vehicles also increased because of greater energy required to overcome drag. For example, it states that for a vehicle traveling at 70 mph, 65% of the total fuel consumption of the engine of the car used to overcome drag. Therefore, even a small reduction in drag experienced by a vehicle traveling at a speed of course would result in a significant improvement in fuel economy.

Our analysis of this patent is as follows:

Smarttruck Systems, Llc’s patent US 9056636 B2 deals with Devices and methods for reducing vehicle drag.
In some embodiments of the present invention, a vehicle trailer is described which includes a shelf component that extends from the side wall of the trailer and that describes a sloped surface.

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Vehicle fuel economy system

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The StormBlok Systems, Inc. patent solves the following problem:

Now most tractor-trailers and about 6-7 mpg fuel leaving significant potential for improving fuel economy of tractor-trailers. Reduced fuel consumption of tractor-trailers that directly impact cost of transportation of goods, serving businesses and consumers alike.

Our analysis of this patent is as follows:

StormBlok Systems, Inc.’s patent US 8985677 B2 deals with Vehicle fuel economy system.
A fairing assembly for a trailer with a wheel set and a hook, the fairing assembly consisting of a fairing connected to an underside of the trailer intermediate hooks, and the wheels set, the fairing including (i) a pair of opposing lateral surfaces separated by a distance, (ii) a lower surface spaced from the underside of the trailer, and (ii) a first face, the first face substantially spanning the distance, where the first face includes an intake opening, wherein at least one of the lower face or the lateral surfaces include an exit opening, and a flow path fluidly connecting the intake openings and exit openings.

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